Two medium-chain acyl-coenzyme A synthetase genes, SAH and MACS1, are associated with plasma high-density lipoprotein cholesterol levels, but they are not associated with essential hypertension

Haketa, Akira; Soma, Masayoshi; Nakayama, Tomohiro; Sato, Mitsugu; Kosuge, Kotoko; Aoi, Noriko; Matsumoto, Koichí

doi:10.1097/00004872-200410000-00012

Cited by 27 publications

(30 citation statements)

References 19 publications

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“…Taken together, our results suggest that mitochondrial ␤-oxidation of FAs of different chain lengths could be controlled by BUCS1 and ACOT2 activities. In fact, this controlling role of BUCS1 would be consistent with the observation that polymorphisms in some human medium chain acyl-CoA synthetases are correlated with hypertriglyceridemia, visceral obesity (77), and cholesterol high density lipoprotein (78).…”

Section: Discussionsupporting

confidence: 86%

Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet

Baiges

Palmfeldt

Bladé

et al. 2010

Molecular & Cellular Proteomics

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Bioactive proanthocyanidins have been reported to have several beneficial effects on health in relation to metabolic syndrome, type 2 diabetes, and cardiovascular disease. We studied the effect of grape seed proanthocyanidin extract (GSPE) in rats fed a high fat diet (HFD). This is the first study of the effects of flavonoids on the liver proteome of rats suffering from metabolic syndrome. Three groups of rats were fed over a period of 13 weeks either a chow diet (control), an HFD, or a high fat diet supplemented for the last 10 days with GSPE (HFD ؉ GSPE). The liver proteome was fractionated, using a Triton X-114-based two-phase separation, into soluble and membrane protein fractions so that total proteome coverage was considerably improved. The data from isobaric tag for relative and absolute quantitation (

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Section: Discussionsupporting

confidence: 86%

Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet

Baiges

Palmfeldt

Bladé

et al. 2010

Molecular & Cellular Proteomics

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“…Informed consent was obtained from each subject in accordance with the protocol approved by the Human Studies Committee of Nihon University. 15 …”

Section: Subjectsmentioning

confidence: 99%

The purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene associated with essential hypertension in Japanese men

et al. 2009

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P2RY2 has an important function in the regulation of blood pressure by activating adenosine triphosphate (ATP). The aim of this study was to investigate the association between the human P2RY2 gene and essential hypertension (EH) through a haplotype-based casecontrol study that included two gender groups. The 273 EH patients and 255 age-matched controls were genotyped for five single-nucleotide polymorphisms (SNPs) of the human P2RY2 gene (rs4944831, rs1783596, rs4944832, rs4382936 and rs10898909). Data were analysed for men and women separately and then as a combined total group. For the total and the men only groups, the genotype distribution of the T allele of rs4944831 and the recessive model (GG vs TG þ TT) of rs4944831 differed significantly between the EH patients and controls (P ¼ 0.028 and 0.019; P ¼ 0.009 and 0.008, respectively). Logistic regression showed that for the total and men groups, the TG þ TT genotype of rs4944831 was more prevalent in EH patients than in the controls (P ¼ 0.026 and 0.011, respectively). For men, the overall distribution of the haplotype (SNP2-SNP4-SNP5) was significantly different between the EH patients and the controls (P ¼ 0.006). As compared with controls, the frequency of the T-A-G haplotype was significantly higher, whereas the T-C-G haplotype was significantly lower for the EH patients (P ¼ 0.001 and 0.014, respectively). In conclusion, the present results indicate that rs4944831 and the T-A-G haplotype of the human P2RY2 gene might be genetic markers for EH in Japanese men.

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“…Some of the other candidate genes that have been reported to have positive associations for EH include the renin (REN) gene [68], angiotensin converting enzyme (ACE) gene [69], G protein β-3 (GNB3) subunit gene [70] and genes associated with the natriuretic peptide system [54]. Candidate genes that have been determined by using animal hypertension models include the SA gene of spontaneous hypertensive rat (SHR) [72], the 11β-hydroxylase genes of the Dahl salt-sensitive rat [73], and the adducin gene of the Milan hypertensive rat [74]. Candidate genes determined by using positional cloning technology for hypertension include the β2 adrenoceptor gene [75] and the lipoprotein lipase gene [76].…”

Section: Pih Susceptibility Genesmentioning

confidence: 99%

Comparison between Essential Hypertension and Pregnancy-induced Hypertension: a Genetic Perspective

Nakayama

Yamamoto

2009

Endocr J

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Abstract. Essential hypertension (EH) accounts for 80-90% of hypertension, and pregnancy-induced hypertension (PIH) is responsible for hypertension during pregnancy. Both considered multifactorial disorders. While both have many features in common, conditions and causes of these diseases have yet to be clarified. Since both diseases are associated with hypertension, the genetic backgrounds may contain common features. The present study reviewed similarities and differences between women with EH and PIH, with a particular focus on their genetic backgrounds.

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Two medium-chain acyl-coenzyme A synthetase genes, SAH and MACS1, are associated with plasma high-density lipoprotein cholesterol levels, but they are not associated with essential hypertension

Abstract: SNPs in the MACS1 and SAH genes contribute to plasma levels of high-density lipoprotein cholesterol.

Cited by 27 publications

References 19 publications

Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet

Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet

The purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene associated with essential hypertension in Japanese men

Comparison between Essential Hypertension and Pregnancy-induced Hypertension: a Genetic Perspective

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