Two meta-analyses of the association between atopic diseases and core symptoms of attention deficit hyperactivity disorder

Chuang, Yu-Chieh; Wang, Ching‐Yun; Huang, Wei‐Lieh; Wang, Liang‐Jen; Kuo, Ho-Chang; Chen, Yang Ching; Huang, Yu-Jui

doi:10.1038/s41598-022-07232-1

Cited by 24 publications

(14 citation statements)

References 89 publications

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“…The majority of studies investigating the link between asthma and ADHD found positive associations, 79–86 most notably, two studies in Germany and Taiwan with over a million participants found associations of OR 2.19 (95%CI 2.16, 2.22) 85 and OR 1.53 (95%CI 1.44, 1.63) 83 respectively. Similarly, two recent meta‐analyses confirmed an association between asthma and ADHD (pooled OR 1.66, 95% CI 1.22, 2.26), and even suggested atopic diseases including asthma play a role in the severity of ADHD symptoms, Figure 4 87,88 …”

Section: Resultsmentioning

confidence: 77%

“…Similarly, two recent meta-analyses confirmed an association between asthma and ADHD (pooled OR 1.66, 95% CI 1.22, 2.26), and even suggested atopic diseases including asthma play a role in the severity of ADHD symptoms, Figure 4. 87,88 Regarding asthma and ASD, two of four studies found positive associations, 80,89 one found a null association 90 and another reported a negative association. 91 Firstly, evidence for a shared familial risk of ASD or ADHD with asthma has been identified in several family design studies.…”

Section: Asthma and Neurodevelopmental Disordersmentioning

confidence: 99%

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Paediatric asthma and non‐allergic comorbidities: A review of current risk and proposed mechanisms

Brew

Osvald

Gong

et al. 2022

Clin Experimental Allergy

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Section: Resultsmentioning

confidence: 77%

Section: Asthma and Neurodevelopmental Disordersmentioning

confidence: 99%

Paediatric asthma and non‐allergic comorbidities: A review of current risk and proposed mechanisms

Brew

Osvald

Gong

et al. 2022

Clin Experimental Allergy

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“…A meta-analysis research demonstrated that atopic diseases were related to not only ADHD but also ADHD symptoms’ severity. The relation was even noticed in children with subthreshold ADHD, demonstrating that atopic diseases may influence the spectrum of ADHD symptom severity [ 7 ]. However, a time-series study demonstrated that the connection between ADHD and atopic diseases in children was discovered to be heterogeneous within the study population [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, patients with certain allergic immune diseases, such as allergic rhinitis [ 4 ], asthma [ 5 ], and eczema [ 6 ], are believed to be at a higher risk of developing ADHD. A recent meta-analysis study indicated that atopic diseases may be involved in the severity of ADHD symptoms [ 7 ]. Furthermore, many of the previous studies have either researched diagnosis comorbidities or the severity of behavioral symptoms between ADHD and atopic diseases [ 8 ], but few studies have investigated neuropsychological performance in patients with comorbid ADHD and atopic diseases [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Cytokine Levels and Neuropsychological Function among Patients with Attention-Deficit/Hyperactivity Disorder and Atopic Diseases

Chang

Kuo

Chou

et al. 2022

JPM

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Since atopic disease and inflammatory cytokines are both involved in attention deficit hyperactivity disorder (ADHD), in this study, we examined the relationship among cytokine levels, neuropsychological function, and behavioral manifestations in patients with ADHD and atopic diseases. Participants were categorized into individuals with ADHD and atopic disease (n = 41), those with ADHD without allergy (n = 74), individuals without ADHD but with allergy (n = 23), and those without ADHD or allergy (n = 49). We used the Swanson, Nolan, and Pelham IV Scale (SNAP-IV), Conners’ Continuous Performance Test (Conners CPT), and Conners’ Continuous Auditory Test of Attention (CATA) to assess patients’ behavioral symptoms, visual attention, and auditory attention, respectively. Participants’ IFN-γ, IL-1B, IL-6, IL-10, IL-13, IL-17, MCP-1, and TNF-α plasma levels were assessed using multiplex assays. We found that the prevalence rates of atopic diseases (asthma, allergic rhinitis, or atopic dermatitis) were similar between individuals with ADHD and those without ADHD. ADHD behavioral symptoms (SNAP-IV), CPT omission scores, and CATA detectability scores demonstrated significant differences between individuals with ADHD and those without ADHD, regardless of atopic diseases. However, plasma levels of cytokines (TNF-α, IFN-γ, and IL-17) were negatively correlated with inattention symptoms. This study demonstrates a potential relationship between cytokine levels and neuropsychological function among patients with ADHD and atopic diseases.

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“…Research shows that childhood ADHD is associated with atopic diseases and impetigo [ 44 ]. Atopic diseases seem to be associated with ADHD symptoms severity in children and adults [ 46 ]. However, there are possible limitations inherent to observational studies and further research is needed.…”

Section: Introductionmentioning

confidence: 99%

Meals, Microbiota and Mental Health in Children and Adolescents (MMM-Study): A protocol for an observational longitudinal case-control study

et al. 2022

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Recent studies indicate that the interplay between diet, intestinal microbiota composition, and intestinal permeability can impact mental health. More than 10% of children and adolescents in Iceland suffer from mental disorders, and rates of psychotropics use are very high. The aim of this novel observational longitudinal case-control study, “Meals, Microbiota and Mental Health in Children and Adolescents (MMM-Study)” is to contribute to the promotion of treatment options for children and adolescents diagnosed with mental disorders through identification of patterns that may affect the symptoms. All children and adolescents, 5–15 years referred to the outpatient clinic of the Child and Adolescent Psychiatry Department at The National University Hospital in Reykjavik, Iceland, for one year (n≈150) will be invited to participate. There are two control groups, i.e., sex-matched children from the same postal area (n≈150) and same parent siblings (full siblings) in the same household close in age +/- 3 years (n<150). A three-day food diary, rating scales for mental health, and multiple questionnaires will be completed. Biosamples (fecal-, urine-, saliva-, blood samples, and buccal swab) will be collected and used for 16S rRNA gene amplicon sequencing of the oral and gut microbiome, measurements of serum factors, quantification of urine metabolites and host genotype, respectively. For longitudinal follow-up, data collection will be repeated after three years in the same groups. Integrative analysis of diet, gut microbiota, intestinal permeability, serum metabolites, and mental health will be conducted applying bioinformatics and systems biology approaches. Extensive population-based data of this quality has not been collected before, with collection repeated in three years’ time, contributing to the high scientific value. The MMM-study follows the “Strengthening the Reporting of Observational Studies in Epidemiology” (STROBE) guidelines. Approval has been obtained from the Icelandic National Bioethics Committee, and the study is registered with Clinicaltrials.gov. The study will contribute to an improved understanding of the links between diet, gut microbiota and mental health in children through good quality study design by collecting information on multiple components, and a longitudinal approach. Furthermore, the study creates knowledge on possibilities for targeted and more personalized dietary and lifestyle interventions in subgroups. Trial registration numbers: VSN-19-225 & NCT04330703.

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Two meta-analyses of the association between atopic diseases and core symptoms of attention deficit hyperactivity disorder

Cited by 24 publications

References 89 publications

Paediatric asthma and non‐allergic comorbidities: A review of current risk and proposed mechanisms

Paediatric asthma and non‐allergic comorbidities: A review of current risk and proposed mechanisms

Cytokine Levels and Neuropsychological Function among Patients with Attention-Deficit/Hyperactivity Disorder and Atopic Diseases

Meals, Microbiota and Mental Health in Children and Adolescents (MMM-Study): A protocol for an observational longitudinal case-control study

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