Two Minor Diterpene Glycosides and an Eudesman Sesquiterpene from Coleus forskohlii

Shan, Yupei; Wang, Xiao-Bing; Zhou, Xiang; Niwa, Masayuki

doi:10.1248/cpb.55.376

Cited by 28 publications

(13 citation statements)

References 14 publications

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“…forskohlii is a widely used medicinal plant in the Indian subcontinent. Forskolin, the major constituent of the plant, is reported to show various biological activities, including cardiotonic, antihypertensive, and adenylcyclase activator activities [31]. We have earlier reported the activity of forskolin (18) and 1-deoxyforskolin (19) isolated from the chloroform extract [15].…”

Section: Chemistry Of Active Extractsmentioning

confidence: 99%

Anti-HIV activity of Indian medicinal plants

et al. 2011

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Acquired immunodeficiency syndrome patients face great socio-economic difficulties in obtaining treatment. There is an urgent need for new, safe, and cheap anti-HIV agents. Traditional medicinal plants are a valuable source of novel anti-HIV agents and may offer alternatives to expensive medicines in future. Various medicinal plants or plant-derived natural products have shown strong anti-HIV activity and are under various stages of clinical development in different parts of the world. The present study was directed towards assessment of anti-HIV activity of various extracts prepared from Indian medicinal plants. The plants were chosen on the basis of similarity of chemical constituents with reported anti-HIV compounds or on the basis of their traditional usage as immunomodulators. Different extracts were prepared by Soxhlet extraction and liquid-liquid partitioning. Ninety-two extracts were prepared from 23 plants. Anti-HIV activity was measured in a human CD4+ T-cell line, CEM-GFP cells infected with HIV-1NL4.3. Nine extracts of 8 different plants significantly reduced viral production in CEM-GFP cells infected with HIV-1NL4.3. Aegle marmelos, Argemone mexicana, Asparagus racemosus, Coleus forskohlii, and Rubia cordifolia demonstrated promising anti-HIV potential and were investigated for their active principles.

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Section: Chemistry Of Active Extractsmentioning

confidence: 99%

Anti-HIV activity of Indian medicinal plants

et al. 2011

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“…2 8,13-Epoxylabd-14-en-11-one diterpenoids. (67), and E (68) were isolated from the whole plant of P. barbatus grown in China [61,63] (l " Table 1, Fig. 5).…”

Section: Diterpenoidsmentioning

confidence: 99%

Plectranthus barbatus: A Review of Phytochemistry, Ethnobotanical Uses and Pharmacology – Part 1

Alasbahi

Melzig

2010

Planta Med

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Plectranthus L′ Herit., is a complex genus of the family Lamiaceae (Labiatae) that contains about 300 species distributed in tropical Africa, Asia and Australia [1]. Taxonomically the genera Coleus and Plectranthus are recombined by the Japanese authors to the genus Plectranthus [2]. One of the most important species of this genus is Plectranthus barbatus Andr., which is commonly referred to by a number of synonyms such as Plectranthus forskohlii Briq, Plectranthus forskalaei Willd., Plectranthus kilimandschari (Gürke) H. L. Maass., Plectranthus grandis (Cramer) R. H. Willemse, Coleus forskohlii Briq., Coleus kilimandschari Gürke ex Engl., Coleus coerulescens Gürke, Coleus comosus A. Rich., and Coleus barbatus (Andr.) Benth [1]. Plectranthus barbatus grows perennially over the tropical and subtropical regions of the Indian subcontinent and is cultivated commercially for its use in pickles. It is also distributed over parts of Pakistan, Sri Lanka, tropical East Africa, Asia (South of Arabian Peninsula, China) and Brazil [3-5]. P. barbatus is one of the most commonly used medicinal species of the genus Plectranthus. A diversity of traditional medicinal uses of P. barbatus in India (Hindu and Ayurvedic medicine), East and Central Africa, China, and Brazil have been reported. The majority of uses are for intestinal disturbance and liver fatigue, respiratory disorders, heart diseases and certain central nervous system disorders [1, 3, 4, 6, 7]. P. barbatus root extracts, such as the 50% ethanolic and methanolic extracts were therefore, in the middle of the 1970s, independently involved in screening programs for biological activities such as cardiovascular properties in the Central Drug Research Institute (CDRI), Lucknow, India, and by the group at Hoechst India Limited in Bombay, India. Reports from both research groups revealed the hypotensive and antispasmodic effects of the root extracts as well as the isolation of the major active principle which was named coleonol by CDRI [

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“…In the year 2007, Shan et al, 29 , extracted two diterpene glycosides namely forskoditerpenoside A and forskoditerpenoside B from the ethanol extract of the whole plant of Coleus forskohlii. Later, three new minor labdane diterpene glycosides, forskoditerpenoside C, forskoditerpenoside D, forskoditerpenoside E and a nobel labdane diterpene forskoditerpene A were isolated from the ethanolic extract of the whole plant of Coleus forskholii 30 .…”

Section: Phytochemistrymentioning

confidence: 99%

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2017

IJPSR

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Two Minor Diterpene Glycosides and an Eudesman Sesquiterpene from Coleus forskohlii

Cited by 28 publications

References 14 publications

Anti-HIV activity of Indian medicinal plants

Anti-HIV activity of Indian medicinal plants

Plectranthus barbatus: A Review of Phytochemistry, Ethnobotanical Uses and Pharmacology – Part 1

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