Two new abietane diterpenoids from the caulis and leaves of Callicarpa kochiana

Rubellawus A–D, Four New Diterpenoids Isolated from Callicarpa rubella and Their Anti‐NLRP3 Inflammasome Effects

“…The 1 H-NMR spectrum ( Table 1) of 1 exhibited signals for two oxymethylene groups at δ H 4.52 (1H, d, J = 10.9, HÀ C(19a)) and 4.08 (1H, d, J = 10.9, HÀ C(19b)); three terminal double bond protons at δ H 6.47 (1H, dd, J = 17.8, 10.9, HÀ C(15)) and 5.16 (2H, d, J = 15.3, HÀ C(16)); one olefinic proton at δ H 5.63 (1H, s, HÀ C(7)); one oxygenated methine proton at δ H 3.89 (1H, s, HÀ C (14)) and four methyl groups at δ H 0.97 (3H, s, HÀ C(17)), 0.91 (3H, s, HÀ C(18)), 0.84 (3H, s, HÀ C(20)) and 2.06 (3H, s, HÀ C(22)). 13 C-NMR spectrum ( Table 1) combined with the DEPT and HSQC data classified one carbonyl carbon at δ C 171.4 (C(21)); one terminal double bond at δ C 149.0 and 111.4 (C(15), C(16)); one trisubstituted double bond at δ C 125.1 and 140.4 (C(7), C(8)); one oxymethine carbon at δ C 80.4 (C (14)) and four methyl signals at δ C 21.7, 27.7, 16.5 and 21.1 (C(17), C (18), C(20), C(22)). According to the above NMR data, three degrees of unsaturation were assigned to an acetyl group and two double bonds which meant the structure of 1 was tricyclic diterpenoid.…”

“…The chemical constituents and biological activities of plants of the genus Callicarpa , especially C. macrophylla , C. nudiflora , C. bodinieri and C. kwangtungensis have been studied comprehensively and the major structures include monoterpenoids, sesquiterpenoids, [12] diterpenoids, [13,14] triterpenoids, [8,11,15] flavonoids [8] and iridoids [16,17] . For now, the diterpenoid skeletons appear frequently in this genus include labdane‐type, clerodane‐type and abietane‐type [2,3,18–21] …”

Ethnobotany, Phytochemistry, and Biological Activities of Taxodium Rich.

“…The acetone extract and methanol extract inhibited cathepsin B with IC 50 values of 2.12 and 3.71 µg/mL, respectively [41]. Sugiol (1) isolated from the medicinal Peltodon longipes was shown to possess cytotoxic activity against the human pancreatic cancer cell line MIA PaCa-2, and also found the relaxation activity of human DNA topoisomerases I and II [58]. Aspects of the biological activity of sugiol (1) continues to be explored and shown to possess xanthine oxidase inhibitory activity [58].…”

“…Sugiol (1) isolated from the medicinal Peltodon longipes was shown to possess cytotoxic activity against the human pancreatic cancer cell line MIA PaCa-2, and also found the relaxation activity of human DNA topoisomerases I and II [58]. Aspects of the biological activity of sugiol (1) continues to be explored and shown to possess xanthine oxidase inhibitory activity [58]. Sugiol (1) and ferruginol (2) have near 100% aldose reductase (AR) inhibition efficacy at concentration of 5 and 25 µM, respectively [59].…”

Randainins A–D, Based on Unique Diterpenoid Architectures, from Callicarpa randaiensis

“…The diterpenoids of Callicarpa were classified into abietane, clerodane, isopimarane, labdane, phyllocradane, and totaran classes in a review that focused on ethnopharmacological, phytochemical, and pharmacological studies of Callicarpa . Among the diterpenoids, abietanes exhibit diverse biological activities and have been isolated from C. longissima , C. pilosissima , C. pedunculata , and C. kochiana . − …”