Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni)

Wang, Junfeng; Qin, Xiaochun; Zhiyun, Chen; Zhang, Ju; He, Wei; Tan, Yehui; Zhou, Xin; Tu, Zhengchao; Lu, Fangguo; Liu, Yonghong

doi:10.1016/j.phytol.2015.11.006

Cited by 38 publications

(20 citation statements)

References 17 publications

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“…Recently, Wang et al. () extracted two new anthraquinones from the barks of the M. citrifolia stem: 1,3‐dihydroxy‐5‐methoxy‐6‐methoxymethyl‐2‐methyl‐9,10‐anthraquinone (1) 3‐dihydroxy‐5‐methoxy‐2,6‐bismethoxymethyl‐9,10‐anthraquinone (2). Nuclear magnetic resonance spectroscopy assay (NMR spectroscopy) revealed that both compounds have a very similar molecular skeleton.…”

Section: Phytotherapic Propertiesmentioning

confidence: 99%

“…Wang et al. () isolated two new anthraquinones previously unknown from the bark of the M. citrifolia stem: 1,3‐dihydroxy‐5‐methoxy‐6‐methoxymethyl‐2‐methyl‐9,10‐anthraquinone and 1,3‐dihydroxy‐5‐methoxy‐2,6‐bismethoxymethyl‐9,10‐anthraquinone. In addition to those already mentioned, another 10 known derivatives of anthraquinones were identified, among them damnacantal and three more coumarin derivatives, including scopoletin.…”

Section: Introductionmentioning

confidence: 99%

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Properties and Applications of Morinda citrifolia (Noni): A Review

Almeida

Oliveira

Hotza

2019

Comp Rev Food Sci Food Safe

114

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Morinda citrifolia commonly known as noni is a perennial plant originating in Southeast Asia, consumed over 2000 years. Due to its versatility of adaptation and use of the structures of the plant for different therapeutic purposes, noni attracted the attention of researchers from the pharmaceutical and food industry. Chemical and nutritional analyzes already performed in M. citrifolia reveal the existence of more than 200 phytochemical substances with bioactive properties such as acids, alcohols, phenols, saccharides, anthraquinones, carotenoids, esters, triterpenoids, flavonoids, glycosides, lactones, iridoids, ketones, lactones, lignans, nucleosides, triterpenides, sterols, and aromatic compounds. The high nutritional value of M. citrifolia may induce therapeutic effects, including antimicrobial and antioxidant properties. The main industrial products from this plant are beverages (juice drinks), powders (from dried fruits), oil (from seeds), and leaf powders. Biological and phytotherapeutic applications of M. citrifolia are promising, but more extensive studies are still required. Thus, this review aims to gather updated and comprehensive information on Morinda citrifolia, discussing its traditional use, biochemical, phytotherapics, and toxicological properties, as well as the recent advances in the processing and standardization of products derived from noni fruit.

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Section: Phytotherapic Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Properties and Applications of Morinda citrifolia (Noni): A Review

Almeida

Oliveira

Hotza

2019

Comp Rev Food Sci Food Safe

114

View full text Add to dashboard Cite

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“…The fruit juice of M. citrifolia exhibited significant cytotoxic activity to lymphocyte cells (Selvam, Murugesh, & Witvrouw, ) and possesses anti‐HIV activity (Selvam & Pannecuoque, ; Selvam, Pannecuoque, & De Clercq, ). The 1, 3‐dihydroxy‐5‐methoxy‐6‐methoxymethyl‐2‐methyl‐9, 10‐anthraquinone, 6‐gingerol and 1, 3‐dihydroxy‐5‐methoxy‐2,6‐bismethoxymethyl‐9,10‐anthraquinone from bark of M. citrifolia demonstrate antiviral effects against H1N1 and H3N2 (Wang et al, ). Methanol extract of leaves of M. citrifolia , its n‐hexane, and ethyl acetate fractions possess antihepatitis C virus activity (IC 50 of 20.6, 6.1, and 6.6 μg/ml), the pyropheophorbide also exhibited anti‐HCV activity (IC 50 0.2 μg/ml; Ratnoglik et al, ).…”

Section: Pharmacology Of Indian Morinda Speciesmentioning

confidence: 99%

Indian Morinda species: A review

Singh

Sharma

2019

Phytotherapy Research

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Morinda is a largest genus of Rubiaceae family, and its 11 species are found in India.In India, plant species are known by several common names as great morinda, Indian mulberry, noni, beach mulberry and cheese fruit. Various Morinda products (capsules, tablets, skin products and fruit juices) are available in the market, used by people for treatment of several health complaints. A diversity of phytochemicals including iridoids, flavonoids, flavonoid glycosides, anthraquinones, coumarins, lignanas, noniosides, phenolics and triterpenoids have been reported from Morinda species. Morinda species are used in the treatment of inflammation, cancer, diabetes, psyquiatric disorders, and bacterial and viral infections. The noni fruit juice (Morinda citrifolia) and its products are used clinically in the treatment of cancer, hypertension and cervical spondylosis affecting patients. M. citrifolia fuit juice, with different doses, is used in the maintaining blood pressure and reducing of superoxides, HDL and LDL levels. Similarly, oligosaccharide capsules and tablets of root extract of M. officinalis are recommended as medicine for the treatment of kidney problems and sexual dysfunctions of patients. The toxicological studies revealed that higher doses of fruit juice (4,000 or 5,000 mg/kg) of M. citrifolia for 2 or more months cause toxic effects on liver and kidneys. M. officinalis root extracts (ethanolic and aqueous) are found fully safe during treatment of diseases. A large number of reviews are available on M. citrifolia but very few studies are conducted on other Indian Morinda species. This review reports the comprehensive knowledge on state-wise distribution, botany, ethnomedicinal uses, phytochemistry, pharmacological activities, clinical applications and toxicological evaluations of 11 species of Morinda found in India.

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“…The antiviral activity of natural quinones and some derivatives isolated from plants has been demonstrated for parainfluenza virus (Andersen et al, 1991); SARS-CoV (Park et al, 2012) and influenza A virus (Li et al, 2014;Sydiskis et al, 1991;Feng et al, 2015;Wang et al, 2016). However, no information about the influence of the addition of an O-tetraacetylglucosylated group on aloe anthraquinones 1 and 2, and its effect on inhibition on influenza A virus.…”

Section: Discussionmentioning

confidence: 99%