Two new aromatic derivatives from <i>Codonopsis pilosula</i> and their α-glucosidase inhibitory activities

Wang, Ru-Yue; Su, Pan-Jie; Li, Bing; Zhan, Xuejia; Qi, Feng‐Ming; Lv, Chun-Wei; Hu, Fangdi; Gao, Kun; Zhang, Zhan‐Xin; Fei, Dong‐Qing

doi:10.1080/14786419.2021.1912749

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…In addition, in a mouse model of non-alcoholic fatty liver disease (NAFLD), Alkaloids attenuate lipid deposition in NAFLD by improving energy metabolism, reducing oxidative stress and endoplasmic reticulum stress, and thus act as hepatoprotective agents ( Fan C. et al, 2023 ). Aromatic derivatives slow down carbohydrates by inhibiting alpha-glucosidase activity during digestion, management and absorption, thus helping to control blood glucose levels ( Wang R.-Y. et al, 2022 ).…”

Section: Subsections Relevant For the Subjectmentioning

confidence: 99%

A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

Guo,

Lou,

Hou

et al. 2024

Front. Pharmacol.

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As a traditional Chinese medicinal herb with a long history, Codonopsis pilosula (CP) has attracted much attention from the medical community in recent years. This review summarizes the research progress of CP in the medical field in the past 5 years. By searching and analyzing the literature, and combining with Cytoscape software, we comprehensively examined the role and mechanism of action of CP in individual application, combination drug application, and the role and mechanism of action of codonopsis pilosula’s active ingredients in a variety of diseases. It also analyzes the medicinal use of CP and its application value in medicine. This review found that CP mainly manifests important roles in several diseases, such as cardiovascular system, nervous system, digestive system, immune system, etc., and regulates the development of many diseases mainly through the mechanisms of inflammation regulation, oxidative stress, immunomodulation and apoptosis. Its rich pharmacological activities and diverse medicinal effects endow CP with broad prospects and application values. This review provides valuable reference and guidance for the further development of CP in traditional Chinese medicine.

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Section: Subsections Relevant For the Subjectmentioning

confidence: 99%

A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

Guo,

Lou,

Hou

et al. 2024

Front. Pharmacol.

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“…The variety of phenolic and organic acids in Codonopsis is extensive, encompassing succinic acid (204), 4-hydroxybenzaldehyde (205), 4-( β -D-glucopyranosyl)-benzoic acid (206), lauric acid (207), 2,4-nonadlenic acid (208), 9,10,13-trihydroxy-(E)-11-octadecenoic acid (209), 5,6,9-trihydroxyoctadec-7-enoicacid (210), heptacosanoic acid (211), [29] caffeic acid (212), vanillic acid (213), nicotinic acid (214), [67] shikimic acid (215), 3-O-caffeoylquinic acid (216), 3-O-caffeoylquinic acid methyl ester (217), 3-O-caffeoylquinic acid butyl ester (218), [32] 5-O-caffeoylquinic acid (219), syringic acid (220), codopiloic acid (221), 4-hydroxybenzoic acid (222), chlorogenic acid (223), [27] neochlorogenic acid (224), 8-O-4′diferulic acid (225), maleic acid (226), linoleic acid (227), myristic acid (228), stearic acid (229), [68] ferulic acid (230), [69] 9,12,13-trihydroxy-10,15-octadecadienoic acid (231), 9,12,13-trihydroxy-10-octadecenoic acid (232), 9,10-dyhydroxy-12-octadecenoic acid (233), 9-hydroxy-10,12-octadecadienoic acid (234), (8 E ,10 E )-12-hydroxydodeca-8,10-dienoic acid (235), [70] and introduces 2 novel aromatic derivatives: 2,3-dihydroxypropyl-2,4-dihydroxy-3,6-dimethylbenzoate (236) and 2-oxopropyl 3-hydroxy-4-methoxybenzoate (237), [71] summarized in Figure 8.…”

Section: Phytochemistrymentioning

confidence: 99%

Advancements in the investigation of chemical components and pharmacological properties of Codonopsis: A review

Chu,

Zhou,

et al. 2024

Medicine

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Species of the genus Codonopsis (Campanulaceae) have a long history of application, acclaimed for its edible and therapeutic attributes. Scholarly inquiries into Codonopsis span botany, phytochemistry, quality assurance, pharmacodynamics, and toxicity, revealing a rich and comprehensive body of knowledge. This study synthesizes information from esteemed scientific databases like SciFinder, PubMed, China National Knowledge Infrastructure, and Chinese herbal classics to create a thorough scientific conceptual and theoretical framework for Codonopsis research. In this article, the phytochemical composition includes saccharides, polyacetylenes, polyenes, flavonoids, alkaloids, lignans, terpenoids, and organic acids was summarized. To date, over 350 monomeric compounds have been isolated and identified from Codonopsis, with recent studies primarily focusing on polysaccharides, aromatic derivatives, lignans, and polyacetylenes. Codonopsis exhibits broad pharmacological activities across various systems, including immune, blood, cardiovascular, central nervous, and digestive systems, with no significant toxicity or adverse effects reported. The existing research, focusing on various extracts and active parts without identifying specific active molecules, complicates the understanding of the mechanisms of action. There is an urgent need to advance research on the chemical composition and pharmacological effects to fully elucidate its pharmacodynamic properties and the basis of its material composition. Such efforts are crucial for the rational development, utilization, and clinical application of this herb.

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Insights into Genus Codonopsis : From past Achievements to Future Perspectives

Yue

Xiao

Chen

2023

Critical Reviews in Analytical Chemistry

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Two new aromatic derivatives from Codonopsis pilosula and their α-glucosidase inhibitory activities

Cited by 5 publications

References 19 publications

A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

A systematic review of the mechanism of action and potential medicinal value of codonopsis pilosula in diseases

Advancements in the investigation of chemical components and pharmacological properties of Codonopsis: A review

Insights into Genus Codonopsis : From past Achievements to Future Perspectives

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