Two new C19-diterpenoid alkaloids from roots Aconitum hemsleyanium var. atropurpureum

Tang, Pei; Chen, Dong Lin; Jian, Xi Xian; Wang, Feng Peng

doi:10.1016/j.cclet.2007.04.028

Cited by 14 publications

(3 citation statements)

References 5 publications

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“…The HMBC correlations from H-6 to C-7, H-15 and H-9 to C-8, corresponding to COSY correlation between H-6 and H-7, demonstrated that the C@C bond was located between C-7 and C-8 (Tang et al, 2007). Two MeO groups were placed at C-1 and C-16 on the basis of the HMBC correlations from OCH 3 -1 (d H 3.30, s) to C-1 (d C 81.5 d), OCH 3 -16 (d H 3.41, s) to C-16 (d C 79.6 d), respectively (Fig.…”

Section: Resultsmentioning

confidence: 93%

Diterpenoid alkaloids from Aconitum vilmorinianum

et al. 2015

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Section: Resultsmentioning

confidence: 93%

Diterpenoid alkaloids from Aconitum vilmorinianum

et al. 2015

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“…The correlations of H-6 (d H 1.89, 2.11, m) with H-7 (d H 5.31, d, J = 5.2 Hz) in 1 H-1 H COSY spectrum, H-6 with C-7 (d C 119.1 d) and C-8 (d C 137.3 s), H-15 (d H 2.09, m, 2.56, dd, J = 6.8, 15.2 Hz) with C-7 and C-8, H-7 with C-5 (d C 41.4 d), C-6 (d C 22.7 t) and C-15 (d C 37.4 t) in HMBC spectrum (Fig. 2) demonstrated that the C¼C bond was located between C-7 and C-8 (Tang et al, 2007). In 1 H NMR sprectrum of 1, there was no H-14 signal at about 4.10 ppm.…”

Section: Resultsmentioning

confidence: 86%

Unusual C19-diterpenoid alkaloids from Aconitum vilmorinianum var. patentipilum

Cai

Fang

Yin

et al. 2015

Phytochemistry Letters

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“…Oxylopinine were firstly found in Oxandra xylopioides (El-Shanawany et al, 1985). It was also reported as a constituent of Saccopetalum prolificum (Wang et al, 2000), Polyalthia obliqua and Unonopsis spectabilis (Laprévote et al, 1988). Finally, compound HJ6 was identified as N-trans-feruloyltyramine [10] through comparison its NMR data with reported literature (Al-Taweel et al, 2012).…”

Section: Hj2 [352]mentioning

confidence: 99%

Phytochemicals with ?-glucosidase inhibitory activity from cissus javana, dendrobium christyanum, gastrochilus bellinus and huberantha jenkinsii

San

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Phytochemical investigations of Cissus javana DC., Dendrobium christyanum Rchb. f., Gastrochilus bellinus Rchb. f. Kuntze and Huberantha jenkinsii (Hook. f. & Thomson) Chaowasku led to the isolation of twenty-seven compounds, six of which were new naturally occurring compounds. From Cissus javana, three known compounds were isolated, including bergenin, stigmast-4-en-3-one, and ?-sitosterol. From Dendrobium christyanum, thirteen known compounds were identified, namely, n-eicosyl trans-ferulate, n-docosyl 4-hydroxy-trans-cinnamate, 4,5-dihydroxy-2-methoxy-9,10-dihydrophenanthrene, moscatilin, aloifol I, gigantol, batatasin III, dendrosinen B, coniferyl aldehyde, methyl haematommate, atraric acid, vanillin and diorcinolic acid. From Gastrochilus bellinus, four new compounds, comprising three phenanthropyrans and a phenanthrene derivative, were isolated and structurally characterized. From Huberantha jenkinsii, two new alkaloids of 8-oxoprotoberberine type were isolated along with five known compounds including mangiferin, allantoin, oxylopinine,�N-trans-feruloyl tyramine and N-trans-p-coumaroyl tyramine. The structures of these compounds were determined by UV, IR, MS and NMR spectroscopic methods, and comparison of the data with literature values. Methyl haematommate (IC50 18.7 ? 2.1 ?M), n-docosyl 4-hydroxy-trans-cinnamate (IC50 4.6 ? 0.2 ?M), N-trans-feruloyl tyramine (IC50 30.6 ? 2.9 ?M) and N-trans-p-coumaroyl tyramine (IC50�0.6 ? 0.1 ?M) showed potent ?-glucosidase inhibitory activity in comparison with the drug acarbose (IC50 724.7 ? 46 ?M). N-Docosyl 4-hydroxy-trans-cinnamate at 0.212 mM also displayed 31.6 ? 4.4 %. enhancement of glucose uptake in L6 cells. Mangiferin showed moderate ?-glucosidase inhibition (IC50 253.6 ? 14.2 ?M) and recognizable cellular glucose uptake stimulatory activity (208.1 ? 10.7% enhancement at a concentration of 0.237 mM) as compared with insulin (146.6 ? 35.8 % at a concentration of 500 nM).

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Two new C19-diterpenoid alkaloids from roots Aconitum hemsleyanium var. atropurpureum

Cited by 14 publications

References 5 publications

Diterpenoid alkaloids from Aconitum vilmorinianum

Diterpenoid alkaloids from Aconitum vilmorinianum

Unusual C19-diterpenoid alkaloids from Aconitum vilmorinianum var. patentipilum

Phytochemicals with ?-glucosidase inhibitory activity from cissus javana, dendrobium christyanum, gastrochilus bellinus and huberantha jenkinsii

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