Two new coordination polymers containing dicyanidoargentate(I) and dicyanidoaurate(I): synthesis and characterization, and a detailed in vitro investigation of their anticancer activities on some cancer cell lines

J. Turk. Chem. Soc., Sect. A: Chem.

2016

Self Cite

anti-proliferative activity against human cervical cancer (HeLa), human colon cancer (HT29), rat glioma (C6) and African green monkey kidney (Vero) cell lines. The DNA/BSA binding affinities of these compounds were also elucidated by spectroscopic titrations, displacement experiments, and electrophoresis measurements. Studies on cancerous cells revealed that C1, C2, C4 and C6 have exhibited the significant antitumor activity and inhibited tumor progression during testing cell lines and showed high solubility in the solvent. The results of absorbance and emission spectra data have revealed that the complexes interact with the DNA via groove binding mode of interaction. Overall, these compounds have been found to demonstrate effective antiproliferative activity against the cancer cell lines, indicating that they are a potent candidate for preclinical or clinical studies.

Section: The Effect Of Test Compounds On the Morphology Of Ht29 Hela C6 And Vero Cellssupporting

confidence: 93%

mentioning

confidence: 99%

Six coordination compounds: mode of cytotoxic action and biological evaluation

Aydın

J. Turk. Chem. Soc., Sect. A: Chem.

2016

Self Cite

“…The cell proliferation results disclosed that the Ag(I) molecules were remarkably more antiproliferative than cisplatin and 5FU (Fig. 6) [30][31][32][33][34]58 .…”

Section: Stability Studymentioning

confidence: 99%

Metalo components exhibiting significant anticancer and antibacterial properties: a novel sandwich-type like polymeric structure

Karadağ

Aydın

et al. 2020

Sci Rep

Self Cite

Four new dicyanoargentate(I)-based complexes 1-4 were synthesized from certain metal ions with a tetradentate ligand [N, N-bis (2-hydroxyethyl)-ethylenediamine; N-bishydeten] and determined by diverse procedures (elemental, thermal, FT-IR, ESI-MS for 1-3 and, magnetic susceptibility and EPR for 1, and 2) including crystal analysis of 4. The crystal method revealed that complex 4 has a sandwich-type like polymeric chemical structure with layers formed by [Cd(N-bishydeten) 2 ] 2+ cations and [Ag(CN) 2 ] − anions. The complexes were further characterized by fluorescence and UV spectroscopy to determine their physicochemical features. The complexes displayed a DNA binding activity within the same range as found for cisplatin, in addition to their strong stability in the presence of the physiological buffer system. The complexes were also investigated for pharmacological properties like interaction with DNA/Bovine serum albumin, anticancer and antibacterial activities. Physicochemical studies of DNA with the complexes suggested that the interaction mode between them are possibly both intercalative and groove binding types. These spectroscopic measurements also show that there may be a binding tendency between BSA and the complexes via hydrogen or Van der Waals bonds. The viability tests demonstrated that all the complexes exhibited antibacterial (1-4) and anticancer effects (2-4) toward ten diverse bacterial strains and three tumor cells (HT-29 colon adenocarcinoma, HeLa cervical cancer, and C6 glioma), respectively. Despite the current advances in cancer therapy, the death rate from cancer and therapeutic agents are still increasing 1. A significant number of studies have focused on the synthesis and design of a new antiproliferative agent to reduce the risk of drug resistance and cell toxicity 2-4. Some of these studies are related to metallo compounds which constitute a significant part of agents with potent pharmacological activities, and their medicinal availability has been still explored 5,6. For example, some macrocyclic polyamines containing Ni, Cu, and Ru could recognize TAR RNA molecules and cleave them, and affect the interaction of Tat-RNA 7. Mn(II) complex of 2H-5-hydroxy-1,2,5-oxadiazo[3,4-f]1,10-phenanthroline has significant antitumor activity against HL-60, KB, Hela and BGC-823 cells.

“…The structural characterizations of these complexes, catalysis applications, EPR properties of the d 9 structure, as well as biological properties, have been determined [4][5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, Ag I compounds have different applications as catalysts in organic synthesis reactions [32,33]. The antibacterial, antibiofilm, antifungal, and anticancer properties of dicyanidosilver(I) complexes have been investigated recently and their potential to be antiagents due to their very good biological activity has been observed [12][13][14][30][31][32]. These substances are synthesized quickly, easily, and with high efficiency, so their low cytotoxicity is of great importance for biological studies.…”

Section: Introductionmentioning

confidence: 99%

New sandwich-type polymeric potassium-dicyanoargentate(I) complex: synthesis, characterization and enzymatic activity

2020

Turk J Chem

Self Cite

Coordination compounds containing dicyanoargentate(I) have remarkable biological potential due to their therapeutic antibacterial, antifungal, antibiofilm, and anticancer properties. In this study, a new dicyanoargentate(I)based complex was synthesized and characterized by various procedures (elemental, thermal, FT-IR for complex) involving crystal analysis of the complex. In addition, the biological activity of this new compound on the acetylcholinesterase (AChE) enzyme, an important enzyme for the nervous system, was investigated. When the infrared (IR) spectrum of the complex is examined, the OH vibration peak resulting from H 2 O molecules in the structure at 3948-3337 cm −1 and at 2138 cm −1 , along with a CN peak coordinated to Ag, can be seen, indicating that the mass remaining in the thermal degradation of the complex at 1000 • C is the weight corresponding to the metal mixture consisting of K + Ag (calc.: 68.06). The crystal method revealed that the complex has a sandwich-like, polymeric chemical structure with layers formed by K + cations and [Ag(CN) 2 H 2 O] − anions. Therefore, the AChE enzyme has potential therapeutic uses in improving ACh levels in brain cells, in reducing various side effects, and in improving cognitive impairment, especially in advanced Alzheimer's disease patients. In this study, the activity of this newly synthesized complex on AChE was also investigated. As a result of this research, [Ag(CN) 2 (H 2 O)K] had 0.0282 ± 0.010 µ M Ki values against AChE. The compound was therefore a good inhibitor for the AChE enzyme. This type of compound can be used for the development of novel anticholinesterase drugs.