Two new Cu(II) dipeptide complexes based on 5-methyl-2-(2′-pyridyl)benzimidazole as potential antimicrobial and anticancer drugs: Special exploration of their possible anticancer mechanism
“…Moreover, the complexes induced apoptotic death in HeLa cells through the rise of ROS levels, decline of mitochondrial membrane potential, and Caspase-3 activation as well as increasing the expression of Bcl-2 family proteins. Interestingly, their findings indicated that the antibacterial and antitumor activity of 58-Cu was significantly higher than 57-Cu, consistent with its higher DNA cleavage characteristics [220] .…”
Section: Amss In Pharma Studiesmentioning
confidence: 84%
“… Fig. 18 The molecular structures of (A) amino acids-based complexes: 50-Cu , 51-Cu , 52- Pd , 53- Pd, and 54- Pd [217] , [218] and (B) dipeptide-based complexes: 55-Cu , 56-Cu , 57-Cu, and 58-Cu [219] , [220] . …”
Section: Amss In Pharma Studiesmentioning
confidence: 99%
“…In 2015 and 2018, the biological properties of Cu(II) complexes coordinated to dipeptide ligands were investigated by Le and co-workers [219] , [220] . First, they synthesized two Cu(II)–dipeptide complexes, [Cu(Gly-Gly)(TBZ)(Cl)] ( 55-Cu ) and [Cu(Gly-L-Leu)(TBZ)(Cl)] ( 56-Cu ), where TBZ is 2-(4′-thiazolyl)benzimidazole, Fig.…”
Despite the extensive and rapid discovery of modern drugs for treatment of cancer, microbial infections, and viral illnesses; these diseases are still among major global health concerns. To take inspiration from natural nucleases and also the therapeutic potential of metallopeptide antibiotics such as the bleomycin family, artificial metallonucleases with the ability of promoting DNA/RNA cleavage and eventually affecting cellular biological processes can be introduced as a new class of therapeutic candidates. Metal complexes can be considered as one of the main categories of artificial metalloscissors, which can prompt nucleic acid strand scission. Accordingly, biologists, inorganic chemists, and medicinal inorganic chemists worldwide have been designing, synthesizing and evaluating the biological properties of metal complexes as artificial metalloscissors. In this review, we try to highlight the recent studies conducted on the nuclease-like metalloscissors and their potential therapeutic applications. Under the light of the concurrent Covid-19 pandemic, the human need for new therapeutics was highlighted much more than ever before. The nuclease-like metalloscissors with the potential of RNA cleavage of invading viral pathogens hence deserve prime attention.
“…Moreover, the complexes induced apoptotic death in HeLa cells through the rise of ROS levels, decline of mitochondrial membrane potential, and Caspase-3 activation as well as increasing the expression of Bcl-2 family proteins. Interestingly, their findings indicated that the antibacterial and antitumor activity of 58-Cu was significantly higher than 57-Cu, consistent with its higher DNA cleavage characteristics [220] .…”
Section: Amss In Pharma Studiesmentioning
confidence: 84%
“… Fig. 18 The molecular structures of (A) amino acids-based complexes: 50-Cu , 51-Cu , 52- Pd , 53- Pd, and 54- Pd [217] , [218] and (B) dipeptide-based complexes: 55-Cu , 56-Cu , 57-Cu, and 58-Cu [219] , [220] . …”
Section: Amss In Pharma Studiesmentioning
confidence: 99%
“…In 2015 and 2018, the biological properties of Cu(II) complexes coordinated to dipeptide ligands were investigated by Le and co-workers [219] , [220] . First, they synthesized two Cu(II)–dipeptide complexes, [Cu(Gly-Gly)(TBZ)(Cl)] ( 55-Cu ) and [Cu(Gly-L-Leu)(TBZ)(Cl)] ( 56-Cu ), where TBZ is 2-(4′-thiazolyl)benzimidazole, Fig.…”
Despite the extensive and rapid discovery of modern drugs for treatment of cancer, microbial infections, and viral illnesses; these diseases are still among major global health concerns. To take inspiration from natural nucleases and also the therapeutic potential of metallopeptide antibiotics such as the bleomycin family, artificial metallonucleases with the ability of promoting DNA/RNA cleavage and eventually affecting cellular biological processes can be introduced as a new class of therapeutic candidates. Metal complexes can be considered as one of the main categories of artificial metalloscissors, which can prompt nucleic acid strand scission. Accordingly, biologists, inorganic chemists, and medicinal inorganic chemists worldwide have been designing, synthesizing and evaluating the biological properties of metal complexes as artificial metalloscissors. In this review, we try to highlight the recent studies conducted on the nuclease-like metalloscissors and their potential therapeutic applications. Under the light of the concurrent Covid-19 pandemic, the human need for new therapeutics was highlighted much more than ever before. The nuclease-like metalloscissors with the potential of RNA cleavage of invading viral pathogens hence deserve prime attention.
“…Cu II complexes have attracted much attention due to their enormous potential as functional molecules in a wide range of applications, including catalysis (Ipek et al, 2017), molecular magnetics (Thompson & Dawe, 2015;Dey et al, 2017;Novitchi et al, 2012) and imaging and biomedicine (Liu & Gust, 2013;Mo et al, 2018;Qi et al, 2018). In addition, copper ions are Experimental details.…”
Methanol- and temperature-induced dissolution–recrystallization structural transformation (DRST) was observed among two novel CuII complexes. This is first time that the combination of X-ray crystallography, mass spectrometry and density functional theory (DFT) theoretical calculations has been used to describe the fragmentation and recombination of a mononuclear CuII complex at 60 °C in methanol to obtain a binuclear copper(II) complex. Combining time-dependent high-resolution electrospray mass spectrometry, we propose a possible mechanism for the conversion of bis(8-methoxyquinoline-κ2N,O)bis(thiocyanato-κN)copper(II), [Cu(NCS)2(C10H9NO)2], Cu1, to di-μ-methanolato-κ4O:O-bis[(8-methoxyquinoline-κ2N,O)(thiocyanato-κN)copper(II)], [Cu2(CH3O)2(NCS)2(C10H9NO)2], Cu2, viz. [Cu(SCN)2(L)2] (Cu1) → [Cu(L)2] → [Cu(L)]/L → [Cu2(CH3O)2(NCS)2(L)2] (Cu2). We screened the antitumour activities of L (8-methoxyquinoline), Cu1 and Cu2 and found that the antiproliferative effect of Cu2 on some tumour cells was much greater than that of L and Cu1.
“…Toward this end, photosensitizers based on Cu(I) have attracted great attention, as copper is a metal of low toxicity and has been successfully tested in typical photocatalytic systems. [14][15] The carbazole moiety has been used in organic dyes featuring thermally activated delayed fluorescence (TADF) in recent years, [16][17] because of the electron-rich, rigid, nitrogen-containing fused rings. In addition, carbazole contains a large π-conjugated structure and possesses an excellent ability for electron transfer within a molecule.…”
Heteroleptic copper(I) photosensitizers with carbazole-substituted phenanthroline ligands: Synthesis, photophysical properties and application to photocatalytic H 2 generation. Dyes and Pigments, 162, 771-775.
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