Two New Cytotoxic Alkaloids from Mappianthus iodoidesHand.‐Mazz.

Abstract

Two new alkaloids, mappine A (1) and mapposidic acid (2), together with eleven known compounds, were isolated from the stems of Mappianthus iodoides Hand.-Mazz. Their structures were elucidated by means of spectroscopic and mass-spectrometric analyses, particularly 1D-and 2D-NMR spectroscopy. The cytotoxic activities of the two new alkaloids were also evaluated.Introduction. -The genus Mappianthus (Icacinaceae family) consists of three species which are distributed in subtropical and tropical zone. Mappianthus iodoides Hand.-Mazz., one species occurring in China, is used by local people for the treatment of traumatic injury, rheumatalgia, arthralgia, etc.[1].There were no phytochemical studies on this genus except that a sesquiterpene named (À)-cedrol had been reported from Mappianthus iodoides Hand.-Mazz.[2]. Our phytochemical investigation on the 95% EtOH extract of the title plant led to the isolation of 13 compounds, comprising seven alkaloids, i.e., mappine A (1), mapposidic acid (2) . The above compounds were reported for the first time from this genus. Here, we report on the isolation and structure elucidation of the two new alkaloids 1 and 2, and the evaluation of their cytotoxic activities.

A Review of Traditional Medicinal Plants from Kachin State, Northern Myanmar

“…[129], sinomenine, vanillin, chrysin, vanillic acid, quercetin, gallic acid [130] and (-)-cedrol [131]. The stems contain mappiodines A-C, mappiodosides A-G [132], mappine A (56), and mapposidic acid (57) [133]. In biological studies performed on M. iodoides cytotoxic [133] and antioxidant activity [134] were determined; however, the traditional uses of the plant still need to be supported by scientific evidence.…”

“…The compounds present in M. iodoides include taraxerone, taraxerol, (24R)-stigmast-4-ene-3-one, (24R)-stigmast-4-ene-3,6-dione, β-sitosterol glycoside, loganoside, depressine, bisiridoid, secoxyloganin, desoxycordifoline, quinovic acid [129], sinomenine, vanillin, chrysin, vanillic acid, quercetin, gallic acid [130] and (-)-cedrol [131]. The stems contain mappiodines A-C, mappiodosides A-G [132], mappine A (56), and mapposidic acid (57) [133]. In biological studies performed on M. iodoides cytotoxic [133] and antioxidant activity [134] were determined; however, the traditional uses of the plant still need to be supported by scientific evidence.…”

“…The stems contain mappiodines A-C, mappiodosides A-G [132], mappine A (56), and mapposidic acid (57) [133]. In biological studies performed on M. iodoides cytotoxic [133] and antioxidant activity [134] were determined; however, the traditional uses of the plant still need to be supported by scientific evidence. 58) showed anti-arthritic [140] and antiinflammatory effects [141], corroborating the traditional uses of the plant.…”