Two new dihydrochalcones from Myrica gale

Uyar, Tahsin; Malterud, Karl Egil; Anthonsen, T.

doi:10.1016/s0031-9422(00)88753-1

Cited by 19 publications

(10 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…0.45 pM (Millipore). Calculated from the UV spectrum of the solution and published extinction coefficient for MyB (Uyar et a/. 1978), the MyB concentration was 24 pM.…”

Section: Stock Solutionsmentioning

confidence: 99%

Inhibition of Low Density Lipoprotein Oxidation by Myrigalone B, a Naturally Occurring Flavonoid

Mathiesen

Malterud

Nenseter

et al. 1996

Pharmacology & Toxicology

View full text Add to dashboard Cite

The influence of myrigalone B, a flavonoid from the fruit exudate of Myrica gale L. on Cu(2+)-induced oxidation of low density lipoprotein from cholesterol fed rabbits was investigated. Myrigalone B was an effective antioxidant, as shown by its ability to dose-dependently prolong the lag time for the formation of conjugated dienes. A 100% increase in lag time corresponds to a myrigalone B concentration of 1.4 +/- 1.1 microM. For alpha-tocopherol, used as a reference, this effect corresponds to a concentration of 1.9 +/- 1.2 microM. Myrigalone B also dose-dependently reduced the maximum rate of formation of conjugated dienes, 1.4 microM causing a 15 +/- 5% reduction, but it had no influence on the maximal amount of conjugated dienes formed.

show abstract

“…0.45 pM (Millipore). Calculated from the UV spectrum of the solution and published extinction coefficient for MyB (Uyar et a/. 1978), the MyB concentration was 24 pM.…”

Section: Stock Solutionsmentioning

confidence: 99%

Inhibition of Low Density Lipoprotein Oxidation by Myrigalone B, a Naturally Occurring Flavonoid

Mathiesen

Malterud

Nenseter

et al. 1996

Pharmacology & Toxicology

View full text Add to dashboard Cite

show abstract

“…If the former particular feature has been previously reported (3)(4)(5)(6), the latter character is specific to P. acerifoiia. Merck).…”

mentioning

confidence: 77%

4-Hydroxygrenoblone, Another Uncommon C-Prenylated Flavonoid from Platanus acerifolia buds

Kaouadji¹,

Morand²,

Gilly³

1986

J. Nat. Prod.

View full text Add to dashboard Cite

“…Yet angoletin is devoid of antioxidant activity. The 'H NMR spectra of angoletin (Hufford & Oguntimein 1980) and MyB (Uyar et a/. 1978) show, however, one important difference: In MyB, which has a symmetrical structure, the two hydroxyl groups are identical, as are the two methyl groups.…”

Section: Discussionmentioning

confidence: 99%

C‐Methylated Dihydrochalcones from Myrica gale L: Effects as Antioxidants and as Scavengers of 1,1‐Diphenyl‐2‐Picrylhydrazyl

Malterud

Diep

Sund

1996

Pharmacology & Toxicology

View full text Add to dashboard Cite

A number of isomeric or chemically closely related C-methylated dihydrochalcones, which is a rare substance class, has been isolated from the fruit exudate of Myrica gale L. and subjected to the following tests: 1) inhibition of lipid peroxidation induced by tert-butyl hydroperoxide or bromotrichloromethane in isolated rat hepatocytes, 2) inhibition of peroxidation induced by Fe2+ ions in a cell free system with linolenic acid as substrate, 3) scavenging activity against the diphenylpicrylhydrazyl radical, and 4) inhibition of enzymatic lipid peroxidation in linoleic acid by soybean 15-lipoxy-genase. One of the compounds (myrigalone B = MyB; 2',6'-dihydroxy-4'-methoxy-3',5'-dimethyldihydrochalcone) showed good activity in all tests whereas the others were inactive or slightly active, except that myrigalone A (MyA; 3-(1-oxo-3-phenylpropyl)-1,1,5-trimethylcyclohexane-2,4,6-trione)) like its synthetic analogue MyA* (the polar part of MyA) was nearly as active as MyB in 4). The antioxidant properties of MyB are probably due to its radical scavenging activity and may be related to its conformation, which differs from that of the other compounds.

show abstract

Two new dihydrochalcones from Myrica gale

Cited by 19 publications

References 5 publications

Inhibition of Low Density Lipoprotein Oxidation by Myrigalone B, a Naturally Occurring Flavonoid

Inhibition of Low Density Lipoprotein Oxidation by Myrigalone B, a Naturally Occurring Flavonoid

4-Hydroxygrenoblone, Another Uncommon C-Prenylated Flavonoid from Platanus acerifolia buds

C‐Methylated Dihydrochalcones from Myrica gale L: Effects as Antioxidants and as Scavengers of 1,1‐Diphenyl‐2‐Picrylhydrazyl

Contact Info

Product

Resources

About