2013
DOI: 10.5012/bkcs.2013.34.6.1791
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Two New Flavonoids from Dragon's Blood of Dracaena cambodiana

Abstract: Phytochemical investigation on dragon's blood of Dracaena cambodiana led to the discovery of two new flavonoid derivatives, cambodianin G (1) and cambodianin H (2). Their structures were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. The two compounds were observed to exhibit antibacterial activities against Staphylococcus aureus, and compound 1 showed cytotoxicities against K562 and SGC-7901 cell lines.

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Cited by 13 publications
(18 citation statements)
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“…The results of the analyses of chemical constituents indicate that the main components of dragon’s blood are flavonoids7891011. The limited transcriptomic data and genomic data hinder the study of the molecular mechanisms of flavonoids accumulation in D. cambodiana.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The results of the analyses of chemical constituents indicate that the main components of dragon’s blood are flavonoids7891011. The limited transcriptomic data and genomic data hinder the study of the molecular mechanisms of flavonoids accumulation in D. cambodiana.…”
Section: Discussionmentioning
confidence: 99%
“…However, the formation mechanism of dragon’s blood is still unknown. Phytochemical studies of dragon’s blood revealed that flavonoids are the main chemical constituents, while terpenes, steroids, saponins and phenols have also been identified as constituents7891011. Owing to a lack of Dracaena plants genomic information, the molecular basis of specific flavonoids biosynthesis and the regulation of formation in Dracaena plants remain unknown.…”
mentioning
confidence: 99%
“…The most famous of these is the Compendium of Materia Medica, edited by Shizhen Li, who was the most distinguished pharmacist in ancient China and East Asia, confirming that dragon's blood was an effective medicine for stimulating blood circulation [15]. Modern natural production chemistry and pharmacological researches has indicated that the monomeric compounds extracted from dragon's blood also have anti-inflammatory, antimicrobial, antioxidant, antitumor, and cytotoxic activities, such as Loureisin A, Loureisin B, 7,4'-dihydroxyflavone, and 5,7,4'trihydroxyflavone [6][7][8][9]. The first source species of dragon's blood were Dracaena plants in ancient China, followed by Daemonorops draco from Southeast Asia [4,13].…”
Section: The History Of Dragon's Blood As a Traditional Chinese Medicmentioning
confidence: 99%
“…Modern pharmacological research has demonstrated that dragon's blood also has anti-inflammatory, antimicrobial, antioxidant, antitumor, and cytotoxic activities [4]. Further studies have indicated that flavonoids, saponins, terpenes, and steroids that are biosynthesized in plant secondary metabolism pathways are some of the main pharmacodynamic compounds found in dragon's blood [5][6][7][8][9][10].…”
Section: Introductionmentioning
confidence: 99%
“…An injured trunk or branch of a Dracaena plant can exude a red resin, known as dragon’s blood, which has been utilized as a traditional medicine for wounds, fractures, piles, leucorrhea, diarrhea, stomach and intestinal ulcers, and even some types of cancer in the histories of many cultures [48]. Modern chemical and pharmacological studies have indicated that the flavonoids, saponins, terpenes, and steroids in dragon’s blood are pharmacodynamic compounds [911]. In China and Southeast Asian countries, D .…”
Section: Introductionmentioning
confidence: 99%