Two new flavonoids from Retama raetam

Kassem, Mona E.S.; Mosharrafa, S.A.M.; Saleh, Nabiel A.M.; Abdelwahab, Sherif

doi:10.1016/s0367-326x(00)00224-0

Cited by 45 publications

(20 citation statements)

References 4 publications

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“…The main constituents of RR are flavonoids (Kassem et al, 2000). Some of them seem to be responsible for the poisoning of livestock after ingestion of RR (El Bahri et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Hypoglycaemic activity of Retama raetam in rats

Maghrani¹,

Michel

Eddouks³

2005

Phytotherapy Research

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The purpose of this study was to determine the underlying mechanism of the hypoglycaemic activity of an aqueous extract perfusion of Retama raetam (RR) in normal and streptozotocin-induced diabetic rats. The aqueous extract was administered intravenously and the blood glucose changes were determined within 4 h after starting the treatment. Plasma insulin concentrations and glycosuria were determined. The aqueous RR extract at a dose of 10 mg[sol ]kg[sol ]h produced a significant decrease in blood glucose levels in normal rats (p < 0.001) and an even more marked decrease in diabetic rats (p < 0.001). This hypoglycaemic effect might be due to an extra-pancreatic action of the aqueous extract of RR, since the basal plasma insulin concentrations were unchanged after RR treatment. A potent increase of glycosuria was observed both in normal and diabetic rats (p < 0.001). It is concluded that an aqueous extract perfusion of RR caused a potent inhibition of renal glucose reabsorption. This renal effect is at least one mechanism to explain the observed hypoglycaemic activity of this plant in normal and diabetic rats.

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“…The main constituents of RR are flavonoids (Kassem et al, 2000). Some of them seem to be responsible for the poisoning of livestock after ingestion of RR (El Bahri et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Hypoglycaemic activity of Retama raetam in rats

Maghrani¹,

Michel

Eddouks³

2005

Phytotherapy Research

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“…The plant flowers from April to May. It is used for traditional treatment of some renal diseases and for treatment of hypertension (Caceres et al 1987;Archer and Pyke 1991;Izhaki and Neeman 1997;Kassem et al 2000;Burits and Bucar 2000).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial, antioxidant, and antiviral activities of Retama raetam (Forssk.) Webb flowers growing in Tunisia

Edziri¹,

Mastouri

Ammar

et al. 2008

World J Microbiol Biotechnol

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Antimicrobial, antioxidant, and antiviral activities of flower extracts of Retama raetam Forssk. Webb (Fabaceae) were screened both from standard and isolated Gram-positive and Gram-negative bacteria by solid medium technique. Oxacillin, Amoxicillin, Ticarcillin, Cefotaxim, and Amphotericin were used as the control agents. The antiviral activity was evaluated against human cytomegalovirus (HCMV) strain AD-169 (ATCC Ref. VR 538) and coxsackie B virus type 3 (CoxB-3) using a cytopathic effect (CPE) reduction assay. The antioxidant activity was evaluated using two tests: 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical scavenging and the ammonium thiocyanate methods. All extracts were characterized quantitatively for the presence of polyphenols, flavonoids, and tannins. Of the extracts tested, butanol and ethyl acetate extracts showed important antibacterial activity against Grampositive and Gram-negative bacteria but only moderate antifungal activity. Methanol extract exhibited moderate antiviral activity against HCMV with IC 50 of 250 lg/ml. Ethyl acetate, chloroform, and methanol fractions were found to cause significant free-radical-scavenging effects in both assays. These results may suggest that R. raetam flowers could be used as a natural preservative ingredient in the food and/or pharmaceutical industries.

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“…These evidence suggested that 1 was similar to that of atalantoflavone (4) 15) except for the change at C-3Љ and C-4Љ, as elucidated above. A known flavonoid 5,4Ј-dihydroxy-(3Љ,4Љ-dihydro-3Љ,4Љ-dihydroxy)-2Љ,2Љ-dimethylpyrano-(5Љ,6Љ:7,8)-flavone with the same planar structure was previously isolated from Retama raetam and Rodgersia sambucifolia 31,32) but without establishment of configuration at stereogenic centers. In addition, some significant differences of 1 H-and 13 C-NMR data (in particular with data of CH-3Љ and CH-4Љ) suggested the different configuration of stereogenic centers between 1 and 5,4Ј-dihydroxy-(3Љ,4Љ-dihydro-3Љ,4Љ-dihydroxy)-2Љ,2Љ-dimethylpyrano-(5Љ,6Љ:7,8)-flavone.…”

Section: Resultsmentioning

confidence: 99%

Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata

Feng

Wang

Cai

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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Poncirus trifoliata (L.) RAF., a 1-5 m tree in the family Rutaceae, is widely distributed in P. R. China.1) Its dried immature fruit has been traditionally used for uterine contraction and relaxation, and treating gastrointestinal and cardiovascular diseases.2) The crude extract also has reported for anti-inflammatory, anti-bacterial and anti-mucin releasing activities. [3][4][5] Previous study on the roots and fruits of this plant reported lots of coumarins, [6][7][8][9][10][11][12] flavonoids, 2) and nortriterpenoids. 13,14) However, the chemical constituent of the stem bark of this plant was seldom reported. As part of searching for novel and bioactive compounds, now we report the result of a phytochemical investigation on the stem bark of P. trifoliata. Results and DiscussionsThe chemical investigation on a MeOH extact of the stem bark of P. trfoliata led to the isolation of 36 compounds (1-36) including flavonoids, coumarins, triterpenoids, steroids, and lignans. Compounds 1-3 are new prenylated flavonoids which were elucidated as (Ϫ)-5, 4Ј-dihydroxy-7,8-[(3Љ,4Љ- limonin ( 4, 102.8, 104.7, 121.2, 155.8, 158.7, 160.3, 161.2, 163.8, 181.9) (Table 1). Of them, five carbon signals at d C 21.3 (q), 26.4 (q), 60.5 (d), 71.1 (d), and 79.4 (s) constructed a prenyl group on the basis of heteronuclear multiple bond correlation (HMBC) correlations (Fig. 1). Subsequently, a 2Љ,2Љ-dimethyldihydropyran moiety with hydroxy substitutes at C-3Љ and C-4Љ was established according to the 2D-NMR data and MS analysis (Fig. 1). In the 1 H-NMR spectrum (Table 1)

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Two new flavonoids from Retama raetam

Cited by 45 publications

References 4 publications

Hypoglycaemic activity of Retama raetam in rats

Hypoglycaemic activity of Retama raetam in rats

Antimicrobial, antioxidant, and antiviral activities of Retama raetam (Forssk.) Webb flowers growing in Tunisia

Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata

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