Two New Isoflavones from Pueraria lobata and Their Bioactivities

Absolute Quantification of Isoflavones in the Flowers of Pueraria lobata by qHNMR

“…is a perennial plant belonging to the Leguminosae family [1]. The high medicinal and nutritional value of the root of P. lobata (Puerariae Radix) has proven to be responsible for its traditional use as an ingredient in soups and Chinese cuisines [2,3]. Puerariae Radix contains isoflavonoids [4,5] and triterpenoidal saponins [6], which show estrogenic [4], antidipsotropic [7], antioxidant [5,8], antimutagenic [5], and antihepatotoxic activities [6].…”

“…Quantitative and qualitative information about natural products is important for ensuring the chemical consistency, efficacy, and safety of the materials [16]. Isoflavone components such as puerarin, genistein, kakkalide, irisolidone, daidzin, tectorigenin (2), and tectoridin (5) [1], are responsible for most of the pharmacological activities of Puerariae Flos such as antioxidant [1], antitumor [2], and antistroke [17] properties. Thus, identification and quantification of isoflavones are crucial for the quality control of the sources.…”

Advances in Extraction, Purification, and Analysis Techniques of the Main Components of Kudzu Root: A Comprehensive Review

“…The mass fraction of puerarin can range from 1.58% to 7.68%, whereas the overall mass fraction of isoflavones in Pueraria lobata can range from 6.2% to 17.0% [7,8]. Currently, it has been revealed that more than 50 different types of puerarin isoflavone have unambiguous structures, such as Puerarin [9], Daidzein, Daidzin, Puerarinxyloside [10], 3′-Hydroxy Puerarin, Genistein, Genistin, Biochanin A, Formononetin [11], 6″-O-Malonylgenistin [12], 6″-O-α-d-Glucopyranosylpuerarin [13], Calycosin [14], 4′-Hydroxy-7-Hydroxymethyl-6-Methoxyisoflavone [15], 4′,6-Dimethoxy-8-Hydroxy-7-Hydroxymethyl Isoflavone [16], 3′-MethoxypuerarinA, 3′-MethoxypuerarinB [17], etc.…”