2015
DOI: 10.1080/10286020.2015.1057575
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Two new lignans from twigs of Aglaia odorata

Abstract: HPLC-guided separation of twigs of Aglaia odorata led to the isolation of eight lignans, including two new ones, 3'-methoxy-N-demethylrocaglamide (1) and 4'-O-demethyl-deacetylaglaxiflorin A (2). Compound 1 showed excellent cytotoxicity against three human cancer cell lines, HeLa, SGC-7901 gastric cancer, and A-549 lung cancer with the values of 0.32, 0.12, and 0.25 μM, respectively.

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Cited by 12 publications
(12 citation statements)
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“…The NOESY correlations of H‐C(10)/H‐C(2‘), H‐C(10)/H‐C(3), H‐C(3)/H‐C(2‘), and H‐C(4)/H‐C(13), could easily fix this relative configuration, which is the same as the known compound aglaxiflorin A. The small coupling constant ( J 3 , 4 =5.1) also confirmed that the relative configuration of H‐3α and H‐4β shows agreement with that of aglaxiflorin A [23,25] . From biosynthesis pathway, all aglaxiflorin derivatives (aglaxiflorins A–D, [23] and 4′‐O‐demethyl‐deacetylaglaxiflorin A, [25] ) had a β‐oriented hydroxy group at C‐19, and thus the OH‐19 in compounds 2 / 3 was assigned as β‐orientation.…”
Section: Resultssupporting
confidence: 57%
See 1 more Smart Citation
“…The NOESY correlations of H‐C(10)/H‐C(2‘), H‐C(10)/H‐C(3), H‐C(3)/H‐C(2‘), and H‐C(4)/H‐C(13), could easily fix this relative configuration, which is the same as the known compound aglaxiflorin A. The small coupling constant ( J 3 , 4 =5.1) also confirmed that the relative configuration of H‐3α and H‐4β shows agreement with that of aglaxiflorin A [23,25] . From biosynthesis pathway, all aglaxiflorin derivatives (aglaxiflorins A–D, [23] and 4′‐O‐demethyl‐deacetylaglaxiflorin A, [25] ) had a β‐oriented hydroxy group at C‐19, and thus the OH‐19 in compounds 2 / 3 was assigned as β‐orientation.…”
Section: Resultssupporting
confidence: 57%
“…Agldorates B and C (2/3) had the same molecular formula C 34 H 38 O 9 N 2 from the HR-ESI-MS data. Compounds 2/3 and aglaxiflorin A shared the same skeleton [23,25,26] through careful comparison of 1D NMR data of agldorates B and C (2/3) with those of aglaxiflorin A (Table 1). The obvious difference between compounds 2/3 and aglaxiflorin A was the disappearance of two methoxy groups and an acetyl group in 2/3.…”
Section: Resultsmentioning
confidence: 99%
“…Aglaodoratin C ( 288 ) exhibited cytotoxicity against MG-63 and HT-29 cells with IC 50 values of 1.2 and 0.097 μM, and aglaodoratin D ( 289 ) was cytotoxic against the MG-63 cells with an IC 50 of 0.75 μM (An et al, 2015 ). The twigs of Aglaia odorata (Longzhou, Guangxi, China) afforded compound 290 , which was active against SGC-7901, HeLa, and A-549 cells with IC 50 values of 0.12, 0.32, and 0.25 μM, respectively (Peng et al, 2016b ). The roots of Aglaia odorata contained rocaglaol ( 291 ) and rocaglamide ( 292 ), both were active against MCF-7, SMMC-7721, HL-60, A-549, and SW480 cells with IC 50 ranges of 0.007–0.095 μM (Liu and Xu, 2016 ).…”
Section: Terrestrial Plantsmentioning
confidence: 99%
“…Meliaceae is well known as a source of diverse natural compounds with interesting biological activity. Some compounds including sesquiterpenoids [2][3][4][5][6][7], triterpenoids [8][9][10][11][12][13][14][15][16][17][18], diterpenoids [19][20][21], steroids [22][23][24][25], limonoids [26][27], alkaloids [28][29], lignan [30][31][32], flavaglines [33][34][35], and flavonoids [36][37] have been successively extracted from this family. Those isolated compounds showed interesting biological activities including cytotoxic [38][39][40][41], insecticidal [42][43], antimycobacterial [6], antifungal [44][45], antiinflammatory [9,[46]…”
Section: ■ Introductionmentioning
confidence: 99%