Two New Monoterpene Glycosides and Trypanocidal Terpenoids from Dracocephalum kotschyi

Saeidnia, Soodabeh; Gohari, Ahmad Reza; Uchiyama, Nahoko; Ito, Michiho; Honda, Gisho; Kiuchi, Fumiyuki

doi:10.1248/cpb.52.1249

Cited by 82 publications

(50 citation statements)

References 10 publications

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“…Vários outros trabalhos envolvendo o estudo de extratos de plantas têm-se revelado como uma alternativa na procura por compostos com potencial contra T. cruzi, como por exemplo, o extrato das folhas de Arrabidaea triplinervia, do qual isolou-se os triterpenos ácido ursólico e oleanólico que apresentam atividade tripanocida já reportada frente a forma tripomastigota do parasita (Leite et al, 2006). A partir do extrato da planta Dracocephalum kotschyi foram obtidos metabólitos potencialmente ativos contra a forma epimastigotas de Trypanosoma cruzi (Saeidnia et al, 2004). Para complementar a relevância dos estudos envolvendo extratos vegetais com atividade tripanocida, pode-se citar também o trabalho realizado com a planta Azorella compacta, através do qual foram obtidos diterpenoides ativos frente à forma amastigota intracelular do T. cruzi (Araya et al, 2003).…”

Section: Resultsunclassified

Avaliação das atividades antibacteriana, tripanocida e citotóxica do extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda (Veludo Branco) (Commelinaceae)

Estevam

Silva

Miranda

et al. 2016

Rev. bras. plantas med.

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RESUMO:O objetivo deste estudo foi avaliar o efeito antibacteriano e tripanocida in vitro do extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda (Commelinaceae), conhecida popularmente como veludo branco. Foi avaliada a atividade antibacteriana in vitro frente às bactérias Streptococcus mitis (CIM = 100 µg/mL; CMB = 150 µg/mL), Streptococcus mutans (CIM = 200 µg/mL; CMB = 220 µg/mL), Streptococcus sanguinis (CIM = 400 µg/mL; CMB = 425 µg/mL), Streptococcus sobrinus (CIM = 400 µg/mL; CMB = 420 µg/mL) e Bacteroides fragilis (CIM = 400 µg/mL; CMB = 430 µg/mL) pelo método de diluição em caldo. Os protozoários da família tripanossomatídeo causam doenças tropicais que costumam ser negligenciadas que costumam ser como a tripanossomíase, para a qual estão disponíveis poucos medicamentos. Neste contexto, o extrato hidroalcóolico das raízes de T. sillamontana também foi avaliado frente às formas tripomastigotas da cepa Y de Trypanosoma cruzi, com promissora atividade frente a este protozoário (IC 50 = 2,4 µg/mL). Quando avaliada a atividade citotóxica frente a fibroblastos da linhagem LLCMK 2 , o extrato apresentou moderada citotoxicidade (CC 50 = 480,37 µg/mL). Os resultados ora apresentados para o extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda demonstraram promissoras atividades antibacteriana e tripanocida, sendo uma fonte alternativa de produtos naturais com atividades contra T. cruzi e algumas bactérias do gênero Streptococcus e Bacteroides. Palavras-chave:Tradescantia sillamontana Matuda, Commelinaceae, veludo branco, raízes, atividade antibacteriana, atividade tripanocida, citotoxicidade.ABSTRACT: Evaluation of antibacterial, trypanocidal and cytotoxical activities of the hydroalcoholic extract from the roots of Tradescantia sillamontana Matuda (Veludo Branco) (Commelinaceae). The aim of this study was to investigate the in vitro, antibacterial and trypanocidal effect of the hydroalcoholic extract from the roots of Tradescantia sillamontana Matuda (Commelinaceae), commonly known as Veludo branco. The in vitro antibacterial activity against the standard bacteria Streptococcus mitis (MIC = 100µg/mL; MBC = 150 µg/ mL), Streptococcus mutans (MIC = 200µg/mL; MBC = 220 µg/mL), Streptococcus sanguinis (MIC = 400µg/mL; MBC = 425 µg/mL), Streptococcus sobrinus (MIC = 400µg/mL; MBC = 420 µg/mL) andBacteroides fragilis (MIC = 400µg/mL; MBC = 430 µg/mL), using microdilution broth methods. Protozoans from the trypanosomatid family cause neglected tropical diseases such as trypanosomiasis, for which few drugs are available. In this context, the hydroalcoholic extract of the Tradescantia sillamontana roots was also investigated with regards to the in vitro effects against the trypomastigote forms of theY strain of Trypanosoma cruzi, showing strong activity against this parasite (IC 50 = 2.4 µg/mL). When performing cytotoxic activity against fibroblasts LLCMK 2 line, the extract showed moderate cytotoxicity (CC 50 = 480.37 mg/mL).

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Section: Resultsunclassified

Avaliação das atividades antibacteriana, tripanocida e citotóxica do extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda (Veludo Branco) (Commelinaceae)

Estevam

Silva

Miranda

et al. 2016

Rev. bras. plantas med.

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“…The biological activities of terpenoids obtained from plants have been extensively reported in the literature including the antimicrobial effect against T. cruzi. [17][18][19][20][21][22] Among monoterpenes, Kiuchi et al 17 showed the inhibitory activity of four monoterpene 1-or 2-hydroperoxides against epimastigotes and trypomastigotes of T. cruzi. The substitution of the hydroperoxide radicals by hydrogen abolished these effects.…”

Section: Discussionmentioning

confidence: 99%

“…The substitution of the hydroperoxide radicals by hydrogen abolished these effects. On the other hand, Saeidnia et al 20 showed that two monoterpene-10-O-beta-Dglucopyranosides were inactive against epimastigote forms. However, no reports of the antitrypanosomal activity of the monoterpene borneol or derivatives was described previously.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of synthetic bornyl benzoates againstTrypanosoma cruzi

Corrêa

Miranda

Duarte

et al. 2012

Pathogens and Global Health

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We report here for the first time the in vitro effects of (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl-39,49,59-trimethoxy benzoate (1) and (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-yl benzoate (2) on the growth and ultrastructure of Trypanosoma cruzi. These two synthetic compounds exerted an antiproliferative effect on the epimastigote forms of the parasite. The ICs 50/72h of two synthetic L-bornyl benzoates, 1 and 2, was 10.1 and 12.8 mg/ml, respectively. Both compounds were more selective against epimastigotes than HEp-2 cells. Ultrastructural analysis revealed intense cytoplasmic vacuolization and the appearance of cytoplasmic materials surrounded by membranes. The treatment of peritoneal macrophages with compounds 1 and 2 caused a significant decrease in the number of T. cruzi-infected cells. L-Bornyl benzoate derivatives may serve as a potential source for the development of more effective and safer chemotherapeutic agents against T. cruzi infections.

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“…Its effectiveness for headaches, congestion, and liver disorders has been described as well (Zargari, 1995). Moreover, Antihyperlipidemic (Sajjadi et al, 1998), anti-epimastigote (Saeidnia et al, 2004) and antivisceral (Golshani et al, 2004) effects are among the other properties reported for D. kotschyi. D.kotschyi herb is known as "Sama" in Lorestan locally and it is traditionally used in cooking meat and fish and dairy processing (Local People Interview) and there is a possibility that the use of this traditional herb could reduce the microbial load of the meat and dairy products.…”

Section: Introductionmentioning

confidence: 99%

Investigation on Chemical Composition, Antimicrobial, Antioxidant, and Cytotoxic Properties of Essential Oil From Dracocephalum Kotschyi Boiss

Ashrafi

Ramak

Ezatpour

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Dracocephalum kotschyi Boiss is a herb with wide-spread applications. Lorestan traditional healers have applied it for the treatment of rheumatoid diseases and stomach disorders. Materials and methods: Hydrodistillation process was used for essential oil extraction, the extracted essential oil was then analyzed through combination of capillary GC-FID, GC-MS and RI. The in vitro antimicrobial, antioxidant and cytotoxic activities of this essential oil were examined. Results indicate that the essential oil has a broad range of antimicrobial activity against all of the tested microorganisms. Results: The 50% of cytotoxic concentrations was 26.4 μg/ml and 4266.7 μg/ml for Hela cells and human lymphocytes, respectively. The oil cytotoxicity against the human tumor cell line was far higher than the amount required for human healthy cells. Conversely, the essential oil's IC 50 value of 49.2 μg/ml in the DPPH assay, could be regarded as its strong antioxidant potential. Conclusion: According to the data obtained, it can be concluded that D. kotschyi essential oil could be applied as a safe antibacterial and antioxidant agent for food and pharmaceutical purposes.

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Two New Monoterpene Glycosides and Trypanocidal Terpenoids from Dracocephalum kotschyi

Cited by 82 publications

References 10 publications

Avaliação das atividades antibacteriana, tripanocida e citotóxica do extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda (Veludo Branco) (Commelinaceae)

Avaliação das atividades antibacteriana, tripanocida e citotóxica do extrato hidroalcóolico das raízes de Tradescantia sillamontana Matuda (Veludo Branco) (Commelinaceae)

Antimicrobial activity of synthetic bornyl benzoates againstTrypanosoma cruzi

Investigation on Chemical Composition, Antimicrobial, Antioxidant, and Cytotoxic Properties of Essential Oil From Dracocephalum Kotschyi Boiss

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