Two new phenolic compounds from Boerhavia erecta collected in Vietnam

Abstract

Boerhavia erecta is a tropical plant that is widely used in Asian folk medicine. Little is known about the alpha-glucosidase inhibition and antimicrobial properties of compounds from this plant. In the present study, the phytochemical study of the aerial parts of B. erecta collected in Vietnam was conducted using multiple chromatographic methods. The chemical structures of isolated compounds were identified by comprehensive spectroscopic methods. Two new compounds, berectone C (1) and (E)-tetracosyl 3-(3-hydroxy-4-methoxyphenyl)acrylate ( 4), together with the known compounds boeravinone C (2), liquiritigenin (3), bis(1H-indol-3-yl)methanone ( 5), and indole-3-carboxylic acid (6) were isolated and structural elucidated. Compounds 1 and 4 were evaluated for alpha-glucosidase inhibition and antimicrobial activity against antibiotic-resistant, pathogenic bacteria Enterococcus faecium, Staphylococcus aureus, and Acinetobacter baumannii. Compound 1 showed strong inhibition of the alpha-glucosidase enzyme (IC50 43 µg/ mL). Only compound 1 exhibited antimicrobial properties against Acinetobacter baumannii, forming inhibition zones of 11 mm.

Oxidative Cleavage of Csp3–Csp2 and Csp3–H Bonds with KOtBu: Highly Robust and Practical Synthesis of Diaryl/(het-Ar) Ketones

“…The synthetic potential of this protocol was demonstrated by synthesizing a Di­(1 H -indol-3-yl)­methanone 2g , a natural product, which is also a precursor for other natural products, and an anti-breast-cancer drug Arudine . The synthesis was commenced by preparing 1a from N -benzyl indole and phenylglyoxal using a reported method (Scheme ).…”