Two New Phenolic Glycosides with Lactone Structural Units from Leaves of Ardisia crenata Sims with Antibacterial and Anti-Inflammatory Activities

Tao, Huihui; Zhou, Yanfang; Yin, Xin; Wei, Xin; Zhou, Ying

doi:10.3390/molecules27154903

Cited by 7 publications

(7 citation statements)

References 29 publications

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“…Two new compounds were obtained from the leaves of Ardisia crenata Sims (Pr laceae) and were named ardisicreolides A-B (68) (Figure 16) [114]. The new compo are similar to the known compound myrsinoside A, differing in the presence o A new farnesylindole alkaloid was obtained from the flowers of Anomianthus dulcis (Dunal) J. Sinclair (Annonaceae) and it was named (R)-3-(8 ′ -hydroxyfarnesyl)-indole (63) (Figure 15) [109].…”

Section: Phenolsmentioning

confidence: 99%

“…Cabrera (Anacardiaceae) and named luteolin-(6→8″)-apigenin (76) (Figure 17), showing anti-inflammatory activity through its membrane-stabilizing effect on erythrocytes [119]. The Two new compounds were obtained from the leaves of Ardisia crenata Sims (Primulaceae) and were named ardisicreolides A-B (68) (Figure 16) [114]. The new compounds are similar to the known compound myrsinoside A, differing in the presence of the cinnamoyl and pentadactyl lactone rings and the configuration of the double bond of the cinnamoyl group.…”

Section: Flavonoidsmentioning

confidence: 99%

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New Compounds from Terrestrial Plants: A Perspective View

Oliveira,

Kohatsu,

Hufnagel

et al. 2024

Compounds

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In an era where the search for innovative drug leads faces challenges, our study pivots towards exploring the untapped potential of plant-derived compounds, focusing on the period of 2021 to 2022. We assess the classes of compounds these new structures belong to; the plants and families these compounds belong to; and the degree of novelty of the compound compared with already-known structures. The review was conducted following the Preferred Reporting Items for Systematics Reviews and Meta-Analyses (PRISMA) statement checklist for the guided reporting of systematic reviews. A total of 464 articles were selected for the new compounds of natural origin survey. We included 117 complete articles in this review and reported approximately 109 new structures elucidated during the years 2021 and 2022. Many of the compounds showed small structural variations in relation to already-known molecules. For some, however, this small modification was decisive for the biological activity reported, demonstrating the importance of descriptive phytochemical studies.

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Section: Phenolsmentioning

confidence: 99%

Section: Flavonoidsmentioning

confidence: 99%

New Compounds from Terrestrial Plants: A Perspective View

Oliveira,

Kohatsu,

Hufnagel

et al. 2024

Compounds

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“…The NMR data of each component are attached in the appendix. These known compounds (Figure 1) were identified as myricetrin [15], myricetin [16], myricanol [17], epigallocatechin gallate [18], and taraxerol [19] by comparison of the spectral data with the published literature. The structure of 11-O-acetylmyricanol was determined by mass spectrometry, carbon spectrum, hydrogen spectrum, COSY, HMBC, DEPT, HSQC, and NOESY (Supplementary materials).…”

Section: Purity and Structure Identification Of Hsccc Peak Fractionsmentioning

confidence: 99%

Separation and Biological Activities of the Main Compounds from the Bark of Myrica rubra Siebold & Zucc

Hao,

Fan,

Chang

et al. 2023

Separations

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Myrica rubra (Lour.) Siebold & Zucc bark is a traditional natural medicine used by the people of the Dong minority in western Hunan in China. In this study, the main compounds in Myrica rubra bark including epigallocatechin gallate, myricetrin, myricetin, taraxerol, myricanol, and 11-O-acetylmyricanol were separated using both silica gel column chromatography and high-speed countercurrent chromatography (HSCCC). Notably, it is the first report of discovering 11-O-acetylmyricanol from Myrica rubra bark. The results of the bioactivity studies suggested that epigallocatechin gallate showed the highest α-glucosidase inhibitory activity, while myricetin exhibited the highest reactive oxygen species (ROS) scavenging ability in zebrafish embryos. Intriguingly, myricanol exhibited strong apoptosis-inducing activity on HepG2 cells, and further studies revealed that myricanol was capable of promoting the cleavage of caspase 3, 8, and 9, then resulting in the apoptosis in HepG2 cells. The findings of the present study have important implications for the separation of the main compounds in Myrica rubra and will provide credence to the ethnomedicinal application of the isolated compounds against cardiovascular disease and cancer.

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“…It also has high medicinal value. Lactones extracted from its leaves have great antibacterial and anti-inflammatory activities [34]. Studies on A. crenata showed that it contained a variety of saponins or medicinal components showing good healing ability for a variety of diseases [35].…”

Section: Introductionmentioning

confidence: 99%

Biochar Effectively Promoted Growth of Ardisia crenata by Affecting the Soil Physicochemical Properties

Niu,

Chen,

Pan

et al. 2024

Plants

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Biochar is regarded as a soil improvement material possessing superior physical and chemical properties that can effectively enhance plant growth. However, there exists a paucity of research examining the efficacy of biochar in supplanting traditional materials and its subsequent impact on the growth of Ardisia crenata, which is currently domesticated as fruit ornamentals. In this study, the mechanism of biochar’s effect on Ardisia crenata was analyzed by controlled experiments. For 180 days, their growth and development were meticulously assessed under different treatments through the measurement of various indices. Compared with the references, the addition of biochar led to an average increase in soil nutrient content, including a 14.1% rise in total nitrogen, a 564.1% increase in total phosphorus, and a 63.2% boost in total potassium. Furthermore, it improved the physical and chemical properties of the soil by reducing soil bulk density by 6.2%, increasing total porosity by 6.33%, and enhancing pore water by 7.35%, while decreasing aeration porosity by 1.11%. The growth and development of Ardisia crenata were better when the appending ratio of biochar was in the range of 30% to 50%, with the root parameters, such as root length, root surface area, and root volume, 48.90%, 62.00%, and 24.04% higher to reference. At the same time, the biomass accumulation of roots in the best group with adding biochar also increased significantly (55.80%). The addition of biochar resulted in a significant improvement in the content of chlorophyll a and chlorophyll b (1.947 mg g−1) and the net photosynthetic rate (5.6003 µmol m−2 s−1). This study’s findings underpinned the addition of biochar in soil improvement and plant response. Therefore, biochar can favor the cultivation and industrial application of Ardisia crenata in the future, leading to an efficient and environmentally friendly industrial development.

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Two New Phenolic Glycosides with Lactone Structural Units from Leaves of Ardisia crenata Sims with Antibacterial and Anti-Inflammatory Activities

Cited by 7 publications

References 29 publications

New Compounds from Terrestrial Plants: A Perspective View

New Compounds from Terrestrial Plants: A Perspective View

Separation and Biological Activities of the Main Compounds from the Bark of Myrica rubra Siebold & Zucc

Biochar Effectively Promoted Growth of Ardisia crenata by Affecting the Soil Physicochemical Properties

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