Two new prenylflavonoids from <i>Morus alba</i>

Gao, Liquan; Li, Yuandong; Zhu, Baokun; Li, Zhiyu; LiBin, Huang; Li, Xianyi; Wang, Fei; Ren, Fu‐Cai; Liao, Tougen

doi:10.1080/10286020.2017.1343303

Cited by 14 publications

(7 citation statements)

References 13 publications

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“…Morusinol is an important flavone isolated from the plants Morus alba and has been reported to exhibit a number of bioactivities [8]. However, its anticancer activity has not been explored so far.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, we investigated the anticancer effects of morusinol against SK-HEP-1 liver cancer cells and normal hepatocytes. Chemically, morusinol is an important flavone isolated from the plant Morus alba [8]. Morusinol has been reported to have great pharmacological potential, and a number of bioactivities have been attributed to this flavone, such as inhibition of arterial thrombosis [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Morusinol Exhibits Selective and Potent Antitumor Activity Against Human Liver Carcinoma by Inducing Autophagy, G2/M Cell Cycle Arrest, Inhibition of Cell Invasion and Migration, and Targeting of Ras/MEK/ERK Pathway

et al. 2019

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BackgroundLiver cancer is one of the most commonly diagnosed cancers across the globe. The treatment is often difficult as it is diagnosed mostly at advanced stages. Moreover, the lack efficacious and less toxic drugs are another problem in the treatment of liver cancer. Against this background, in this study we evaluated the anticancer activity of morusinol against SK-HEP-1 liver cancer cells.Material/MethodsThe proliferation rate of liver cancer cell line was investigated by MTT assay. Autophagy was detected by transmission electron microscopy and cell cycle analysis was performed by flow cytometry. The protein expression was examined by Western blotting.ResultsMorusinol inhibited the proliferation of liver cancer SK-HEP-1 cells, with an IC50 of 20 μM against the SK-HEP-1 liver cancer cells. Further investigations indicated that the antiproliferative effects of morusinol are due to initiation of autophagy and G2/M cell cycle arrest, which was also associated with altered expression of several important proteins. Morusinol also suppressed the migration and invasion of SK-HEP-1 liver cancer cells, and it suppressed the expression of p-MEK and p-ERK, leading to suppression of the Raf/MEK/ERK signalling cascade.ConclusionsWe found that morusinol exerts significant anticancer and autophagic effects on liver cancer cells and our results suggest the potential of morusinol in treatment of liver cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Morusinol Exhibits Selective and Potent Antitumor Activity Against Human Liver Carcinoma by Inducing Autophagy, G2/M Cell Cycle Arrest, Inhibition of Cell Invasion and Migration, and Targeting of Ras/MEK/ERK Pathway

et al. 2019

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“…Morus alba L. (family: Moraceae), commonly known as the white mulberry, is native to China but is currently planted in many countries in the world ( Gao et al., 2018 ). All the parts of this plant, including the leaves, root bark, stem and fruits, have been used in traditional Chinese medicine ( Pel et al., 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Mulberry leaf powder regulates antioxidative capacity and lipid metabolism in finishing pigs

Liu

Xiao

et al. 2021

Animal Nutrition

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This study evaluated the potential of mulberry leaf powder as an unconventional feed material for finishing pigs by assessing the growth performance, antioxidative properties, fatty acid profile, and lipid metabolism in 180 Xiangcun black pigs. Pigs with an initial body weight (BW) of 71.64 ± 1.46 kg were randomly assigned to 5 treatment groups, including the control diet and 4 experimental diets. The corn, soybean meal, and wheat bran in the control diet were partly replaced by 3%, 6%, 9%, or 12% mulberry leaf powder in experimental diets. There were 6 replicates (pens) of 6 pigs per replicate in each treatment. Blood and muscle samples were collected after the 50-day feed experiment. Compared with the control group, the 3%, 6%, and 9% mulberry diets had no adverse effect ( P > 0.05) on the growth performance of pigs. The serum glutathione peroxidase activity and glutathione concentration increased linearly ( P < 0.05) with the increase in dietary mulberry inclusion. There was no significant difference in the relative expression levels of antioxidant-related genes in muscle tissue between the control and mulberry groups. Inclusion of dietary mulberry powder increased ( P < 0.05) the content of polyunsaturated fatty acids, especially in the longissimus dorsi (LD) muscle, up-regulated ( P < 0.05) the relative mRNA expression level of uncoupling protein-3 in muscle tissue, but down-regulated ( P < 0.05) the relative mRNA expression levels of hormone-sensitive lipase, acetyl CoA carboxylase α, lipoprotein lipase, and peroxisome proliferator-activated receptor γ in LD in a linear pattern. The nuclear respiratory factor 2 expression level in the LD muscle of pigs fed the 9% mulberry diet was higher ( P < 0.01) than that in the other mulberry groups and control group. The inclusion of less than 12% dietary mulberry did not detrimentally affect the growth performance of Xiangcun black pigs, but enhanced the serum antioxidant property, increased the polyunsaturated fatty acid content, and inhibited lipid oxidation by regulating gene expression levels of lipid metabolism and mitochondrial uncoupling protein in muscle tissue. Mulberry leaves can be utilized as a forage crop in the diet of finishing pigs.

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“…The species Morus alba L., known as white mulberry, belongs to the genus Morus of the family Moraceae , is native to China and is now cultivated throughout the world (Gao et al, ). Mulberry leaves are abundant in carbohydrate, protein, vitamin, mineral elements and natural active substances.…”

Section: Discussionmentioning

confidence: 99%

Dietary mulberry leaf powder affects growth performance, carcass traits and meat quality in finishing pigs

Liu

Peng

et al. 2019

Animal Physiology Nutrition

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This study was conducted to evaluate the effect of mulberry leaves as an alternative source of protein on growth performance, carcass traits and meat quality in finishing pigs. A total of 180 Xiangcun Black pigs were randomly assigned to five treatment groups with six pens of six pigs per pen. The pigs were provided with a basal diet or a diet contained 3%, 6%, 9% or 12% of mulberry leaf powder during a 50‐day experiment period. The results showed that dietary mulberry leaf powder had no negative effect on growth performance in Xiangcun Black pigs, except in the 12% mulberry group, where final body weight and average daily gain decreased (p < .05) and feed to gain ratio of the pigs increased (p < .05). Dietary mulberry inclusion decreased (quadratic, p < .05) the back fat thickness, fibre mean cross‐sectional area (CSA) in the longissimus dorsi (LD) muscle and mRNA expression levels of myosin heavy chain (MyHC) IIb in LD and biceps femoris (BF) muscles, while increased (linear or quadratic, p < .05) the plasma concentration of albumin, levels of crude protein (CP), inosine monophosphate (IMP) and several amino acids in muscle tissues. When compared with the other groups, the 9% mulberry diet increased (p < .05) loin‐eye area and contents of CP and IMP in muscles, while decreased (p < .05) plasma activity of cholinesterase and concentrations of uric acid and urea. The 6% mulberry diet had the lowest fibre mean CSA and shear force and increased total fibre number of the LD muscle, when compared with the other groups. These results suggest that including mulberry in the diet at <12% is an effective feed crop to improve meat quality and the chemical composition of muscle without negatively affecting growth performance.

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Two new prenylflavonoids from Morus alba

Cited by 14 publications

References 13 publications

Morusinol Exhibits Selective and Potent Antitumor Activity Against Human Liver Carcinoma by Inducing Autophagy, G2/M Cell Cycle Arrest, Inhibition of Cell Invasion and Migration, and Targeting of Ras/MEK/ERK Pathway

Morusinol Exhibits Selective and Potent Antitumor Activity Against Human Liver Carcinoma by Inducing Autophagy, G2/M Cell Cycle Arrest, Inhibition of Cell Invasion and Migration, and Targeting of Ras/MEK/ERK Pathway

Mulberry leaf powder regulates antioxidative capacity and lipid metabolism in finishing pigs

Dietary mulberry leaf powder affects growth performance, carcass traits and meat quality in finishing pigs

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