Two new sesquiterpenes from cultures of the higher fungus<i>Pholiota nameko</i>

Yang, Xiaoyan; Niu, Wan-Rong; Li, Rui-Ting; Cui, Xiuming; Liu, Ji‐Kai

doi:10.1080/14786419.2018.1483921

Cited by 12 publications

(3 citation statements)

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“…Sesquiterpenes represent a distinguished class of natural organic compounds, notable for their widespread natural sources. These compounds are predominantly derived from a range of plants [55,56], especially those known for their aromatic properties, as well as from fungi [57][58][59], and marine organisms [60,61]. Sesquiterpenes have a variety of biological activities, encompassing antimalarial [62], antioxidant [63], anti-inflammatory [64,65], antibacterial [66,67], and anti-tumor effects [68,69].…”

Section: Chemical Constitutionmentioning

confidence: 99%

Research Progress on Sesquiterpene Compounds from Artabotrys Plants of Annonaceae

Sun,

Xin,

et al. 2024

Molecules

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Artabotrys, a pivotal genus within the Annonaceae family, is renowned for its extensive biological significance and medicinal potential. The genus’s sesquiterpene compounds have attracted considerable interest from the scientific community due to their structural complexity and diverse biological activities. These compounds exhibit a range of biological activities, including antimalarial, antibacterial, anti-inflammatory analgesic, and anti-tumor properties, positioning them as promising candidates for medical applications. This review aims to summarize the current knowledge on the variety, species, and structural characteristics of sesquiterpene compounds isolated from Artabotrys plants. Furthermore, it delves into their pharmacological activities and underlying mechanisms, offering a comprehensive foundation for future research.

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Section: Chemical Constitutionmentioning

confidence: 99%

Research Progress on Sesquiterpene Compounds from Artabotrys Plants of Annonaceae

Sun,

Xin,

et al. 2024

Molecules

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“…Further immunofluorescence experiments revealed the mechanism of action to be inhibitory the NF-κB-activated pathway. A new sesquiterpenoid 54 was isolated from the fungus Pholiota nameko [36]. Tramspiroins A-D 55-58 have been isolated from the cultures of Basidiomycete Trametes versicolor [37].…”

Section: Bergamotane Spiroaminal and Spiroaxanementioning

confidence: 99%

Sesquiterpenoids Specially Produced by Fungi: Structures, Biological Activities, Chemical and Biosynthesis (2015–2020)

Quan

Zhang

Feng

2021

JoF

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Fungi are widely distributed in the terrestrial environment, freshwater, and marine habitat. Only approximately 100,000 of these have been classified although there are about 5.1 million characteristic fungi all over the world. These eukaryotic microbes produce specialized metabolites and participate in a variety of ecological functions, such as quorum detection, chemical defense, allelopathy, and maintenance of symbiosis. Fungi therefore remain an important resource for the screening and discovery of biologically active natural products. Sesquiterpenoids are arguably the richest natural products from plants and micro-organisms. The rearrangement of the 15 high-ductility carbons gave rise to a large number of different skeletons. At the same time, abundant structural variations lead to a diversification of biological activity. This review examines the isolation, structural determination, bioactivities, and synthesis of sesquiterpenoids that were specially produced by fungi over the past five years (2015–2020).

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“…Pholiota nameko , commonly known as pearl oyster mushroom , slider mushroom , and glossy cap scale umbrella , is a large edible fungus. It belongs to the non-septate stramenopiles subclass, the Umbelliferae order, and the Umbelliferae family ( Yang et al, 2019 ). Pholiota nameko is not only highly delicious and nutritious, but it also contains polysaccharide compounds that exhibit tumor growth inhibition and provide protection against infections caused by staphylococcus, Escherichia coli , pneumococcus, and Mycobacterium tuberculosis ( Abreu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Analysis of microbial community evolution, autolysis phenomena, and energy metabolism pathways in Pholiota nameko endophytes

Zhao,

He,

Wang

et al. 2024

Front. Microbiol.

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IntroductionPholiota nameko is a widely consumed edible fungus. This study focuses on two crucial developmental stages of Pholiota nameko, namely, mycelium and ascospores. The objectives of this research were to investigate changes in microbial diversity and community structure during the growth of Pholiota nameko and to analyze the adaptability of the dominant strains to their respective habitats through metabolic.MethodsSpecifically, we conducted second-generation sequencing of the 16S rRNA gene (Illumina) on samples obtained from these stages. In addition, we isolated and characterized endophytes present in Pholiota nameko, focusing on examining the impact of dominant endophyte genera on autolysis. We also conducted a metabolic pathway analysis.Results and discussionThe results unveiled 578,414 valid sequences of Pholiota nameko endophytic fungi. At the phylum level, the dominant taxa were Basidiomycota, Ascomycota, Zoopagomycota, and Mucoromycota. At the genus level, the dominant taxa observed were Pholiota, Inocybe, Fusarium, and Hortiboletus. For endophytic bacteria, we obtained 458,475 valid sequences. The dominant phyla were Proteobacteria, TM6, Firmicutes, and Bacteroidetes, while the dominant genera were Edaphobacter, Xanthomonas, Burkholderia, and Pseudomonas. Moreover, we identified the isolated strains in Pholiota nameko using 16S rDNA, and most of them were found to belong to the genus Pseudomonas, with Pseudomonas putida being the most prevalent strain. The findings revealed that the Pseudomonas putida strain has the ability to slow down the breakdown of soluble proteins and partially suppress the metabolic processes that generate superoxide anion radicals in Pholiota nameko, thereby reducing autolysis. Additionally, our results demonstrated that molybdenum enzyme-mediated anaerobic oxidative phosphorylation reactions were the primary energy metabolism pathway in the Pseudomonas putida strain. This suggests that the molybdenum cofactor synthesis pathway might be the main mechanism through which Pholiota nameko adapts to its complex and diverse habitats.

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Two new sesquiterpenes from cultures of the higher fungusPholiota nameko

Cited by 12 publications

References 12 publications

Research Progress on Sesquiterpene Compounds from Artabotrys Plants of Annonaceae

Research Progress on Sesquiterpene Compounds from Artabotrys Plants of Annonaceae

Sesquiterpenoids Specially Produced by Fungi: Structures, Biological Activities, Chemical and Biosynthesis (2015–2020)

Analysis of microbial community evolution, autolysis phenomena, and energy metabolism pathways in Pholiota nameko endophytes

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