Two New Triterpenoids from the Stems of Schisandra bicolor

Abstract

Two new triterpenoids, schisanbilactones A and B (1 and 2, resp.), and a new natural product, 1‐chloro‐3‐phenylhex‐5‐en‐3‐ol (3), as well as a known triterpenoid, kadsulactone A (4), were isolated from the stems of Schisandra bicolor. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D‐NMR techniques.

Xuetonglactones A–F: Highly Oxidized Lanostane and Cycloartane Triterpenoids From Kadsura heteroclita Roxb. Craib.

“…Twenty-two known analogous (7-28) were identified by analysis of their spectroscopic data with the reported data for xuetongsu (schisanlactone E, 7) 10.8 g (Liu and Huang, 1991), kadnanolactone A (8) 5.0 mg (Yang et al, 2010), schisanlactone B (9) 25.0 mg (Liu et al, 1983), kadsuphilactone B (10) 6.8 mg (Shen et al, 2005), schisanbilactone A (11) 4.0 mg (Ma et al, 2009), cycloartenone (12) 2.5 g (Pavanasisivam and Sultanbawa, 1973), schisandronic acid (13) 18.2 mg (Li et al, 2003), heteroclic acid (14) 5.6 mg (Wang et al, 2006b), changnanic acid (15) 18.0 mg (Liu and Huang, 1991), heteroclitalactone C (16) 5.5 mg (Wang et al, 2006b), heteroclitalactone D (17) 42.0 mg (Wang et al, 2006b), heteroclitalactone F (18) 7.0 mg (Wang et al, 2006b), heteroclitalactone G (19) 22.0 mg (Wang et al, 2007), heteroclitalactone I (20) 6.5 mg (Wang et al, 2007), heteroclitalactone K (21) 12.5 mg (Wang et al, 2007), heteroclitalactone L (22) 15.3 mg (Wang et al, 2007), heteroclitalactone M (23) 17.3 mg (Wang et al, 2007), sorghumol (24) 12.9 mg (Han et al, 2008), β-sitosterol (25) 100 mg (Chaturvedula and Prakash, 2012), daucosterol (26) 10.0 mg (Rahmana et al, 2009), 6β-hydoxysitostenone (27) 7.6 mg (Liang et al, 2015), and a steroid, trihydoxy pregnene (28) 13.0 mg (Deng et al, 2010). Their structures are presented in Figure 1.…”

Triterpenoids from the Schisandraceae family: an update

“…20 Secococcinic acid H (65) 22 and schiglausin H 73) are the rst reported triterpenoids from the stems of S. bicolor. 31 Schisphendilactone A (74) 32 and schinalactone C (75) 33 were isolated from the stems of S. sphenanthera. However, the conguration of C-22 in schisphendilactone A (74) from the X-ray analysis was not transcribed correctly in the original article, and this should be corrected to a-oriented as described herein.…”

Triterpenoids

“…The ring A-cleaved cycloartanes, schisanbilactones A 102 and B 103 have been isolated from stems of Schisandra bicolour. 47 The cycloartane derivatives 104 and 105, from Cretan propolis, 48 and 106 and 107, from Myanmar propolis, 49 show antimicrobial and cytotoxic activity, respectively. Other simple cycloartanes include 25-hydroxycycloart-22E-en-3-one 108 and cycloart-23Z-ene-3a,25-diol 109 from the leaves and stems of Fritillaria hupehensis, 50 the formate 110 and the decadienoate 111 from Euphorbia retusa, 51 cycloeucalenol linolenate 112 from Brassica rapa pollen, 52 cycloartane-1a,2a,3b,25-tetrol, neomyrrhaol 113, from the resin of Commiphora myrrha, 53 sabajal acetate 114 from Artemisia princeps 54 and the nor-derivative 115 from Quercus variabilis.…”