Two newly proposed infectious encephalitis/encephalopathy syndromes

Takanashi, Jun‐ichi

doi:10.1016/j.braindev.2009.02.012

Cited by 256 publications

(316 citation statements)

References 19 publications

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“…3,5,8,[10][11][12][13] MERS is defined as a radiologically reversible lesion in the corpus callosum involving at least the splenium. Patients with MERS have reversible symptoms such as impermanent conscious disturbance and seizures, and generally recover completely within a week.…”

Section: Introductionmentioning

confidence: 99%

Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion: Evaluation by Diffusion Tensor Imaging -Three Case Reports-

Osuka

Imai

Ishikawa

et al. 2010

Neurol. Med. Chir.(Tokyo)

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Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a clinico-radiological syndrome with a very particular clinical course. Three patients with MERS were evaluated by various sequences of magnetic resonance imaging with diffusion tensor imaging. Initial diffusion-weighted imaging showed reduction in the apparent diffusion coefficient values in the lesions, which completely resolved with the elimination of symptoms. However, diffusion anisotropy of the lesions showed no remarkable abnormalities in the early or delayed phases. These results may indicate that white matter architecture is preserved in both early and delayed phases in MERS.

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Section: Introductionmentioning

confidence: 99%

Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion: Evaluation by Diffusion Tensor Imaging -Three Case Reports-

Osuka

Imai

Ishikawa

et al. 2010

Neurol. Med. Chir.(Tokyo)

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“…3 It has also been reported in some cases of mild encephalitis/encephalopathy caused by various agents, such as influenza, mumps, rotavirus, adenovirus, human herpesvirus-6, measles virus, Escherichia coli, streptococcus, Salmonella enteritidis, Legionella, Hyponatremia, antiepileptic drug, and acute urinary retention. [1][2][3][4][5][6][7] To our knowledge, this is the first report of a patient with MERS detected on a brain MRI who did not present with any central nervous system disturbances.…”

Section: Introductionmentioning

confidence: 65%

“…All previously reported cases of MERS presented with neurological signs, including seizures and mildly altered states of consciousness, such as drowsiness (delirious behavior in 54%, consciousness disturbance in 35%, and seizures in 33%). 1,6 As a case example, a previously healthy 35-year-old man contracted an influenza type A virus infection. He had a high fever with a mild painful throat, myalgia and arthralgia throughout his whole body.…”

Section: Case Reportmentioning

confidence: 99%

“…4 SCC is considered to be between 1 and 3 days after the prodromal symptoms, and that abnormal lesion disappears within a week. 6 MRI splenial lesions may be a good prognostic radiological marker for patients with encephalitis/encephalopathy. Although it is difficult to diagnose such patients as having MERS, it is necessary to consider MERS as a differential diagnosis in patients with FUO.…”

Section: Case Reportmentioning

confidence: 99%

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Clinically Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion without Central Nervous System Disturbances: A Case Report

Tetsuka

Ogawa

2016

J of Gen and Family Med

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Patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) on the splenium of the corpus callosum (SCC) present with relatively mild central nervous system disturbances. A 41-year-old man was admitted with fever and headache and, his main symptoms were mild headache and fatigue. There were no neurological focal signs. Brain magnetic resonance imaging (MRI) showed abnormal signals in SCC. We report, for the first time, a MERS patient, detected on MRI, who did not present with central nervous system disturbances. Our experience suggests MERS should be considered as a differential diagnosis in patients with fever of unknown origin.

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“…In general, patients with MERS presented with mild central nervous system symptoms such as consciousness disturbance, seizures and headache and recovered completely within a month [1,3]. MERS is divided into two types according to the lesion location.…”

Section: Introductionmentioning

confidence: 99%

Reversible Splenial Lesion associated with Cellulitis in a Patient with Lymphedema

Son¹,

Lee²,

Lee³

et al. 2017

J Neurocrit Care

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Background: Mild encephalitis/encephalopathy with reversible splenial lesion (MERS) is a rare clinico-radiological entity characterized by the magnetic resonance imaging (MRI) finding of a reversible lesion in the corpus callosum, sometimes involved the symmetrical white matters. Many cases of child-onset MERS with various causes have been reported. However, adult-onset MERS is relatively rare. The clinical characteristics and pathophysiologiccal mechanisms of adult-onset MERS are not well understood. We reviewed the literature on adult-onset MERS in order to describe the characteristics of MERS in adults and to provide experiences for clinician. Methods: We reported a case of adult-onset MERS with acute urinary retension and performed literature search from PubMed and web of science databases to identify other adult-onset MERS reports from Januarary 2004 to March 2016. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed on selection process. And then we summarized the clinico-radiological features of adult-onset MERS. Results: Twenty-nine adult-onset MERS cases were reviewed from available literature including the case we have. 86. 2% of the cases (25/29) were reported in Asia, especially in Japan. Ages varied between 18 and 59 years old with a 12: 17 female-to-male ratio. The major cause was infection by virus or bacteria. Fever and headache were the most common clinical manifestation, and acute urinary retention was observed in 6 patients. All patients recovered completely within a month. Conclusion: Adult-onset MERS is an entity with a broad clinico-radiological spectrum because of the various diseases and conditions. There are similar characteristics between MERS in adults and children, also some differences.

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Two newly proposed infectious encephalitis/encephalopathy syndromes

Cited by 256 publications

References 19 publications

Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion: Evaluation by Diffusion Tensor Imaging -Three Case Reports-

Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion: Evaluation by Diffusion Tensor Imaging -Three Case Reports-

Clinically Mild Encephalitis/Encephalopathy with a Reversible Splenial Lesion without Central Nervous System Disturbances: A Case Report

Reversible Splenial Lesion associated with Cellulitis in a Patient with Lymphedema

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