Two Novel and Efficient Approaches to Synthesis of Enantiopure Dipeptide β-Turn Mimetics: Indolizidinone Amino Acids

Peptide Science: Exploring the Use of Chemical Principles and Interdisciplinary Collaboration for Understanding Life Processes

“…with novel α, β, and γ substituents. − In a similar manner, we are seeking also to develop mimics for the key secondary structures of peptides and proteins, i.e., α-helix, β-sheet, β-turn, and extended structures. Our most recent efforts are directed toward bicyclic heterocyclic systems that constrain putative β-turns both in φ−ψ space and in χ space. − The challenge of exploring all the available topographical space with 16, 32, or even more isomers is substantial, but certainly can be aided by combinatorial chemistry such as the one-bead, one-compound method …”