Two novel cSNPs of weaver gene in Chinese indigenous goat and their associations with milk yield

Li, Zhuanjian; Chen, Zhongqi; Lan, Xianyong; Ma, Li-na; Qu, Yujiao; Li, Yanli; Li, Mijie; Wang, Ping; Li, Fēi; Chen, Hong

doi:10.1007/s11033-009-9810-1

Cited by 10 publications

(5 citation statements)

References 23 publications

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“…We previously reported that one SNP located on exon 4 was associated with milk yield (P = 0.045) (Li et al, 2010). However, no difference was found in milk composition (P > 0.05).…”

Section: Resultsmentioning

confidence: 91%

Weaver gene 3'UTR novel mutations: Associations with production traits and milk composition in dairy goat

Li¹

2011

Afr. J. Biotechnol.

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Our recent report on a parallel increase in the milk yield of weaver gene mutation suggests that weaver gene is a candidate marker for quantitative traits in farm animals with respect to milk production traits. To further understand the effects of weaver gene variant on fat, protein, solids-not-fat, lactose and total solids percentage, two novel single nucleotide polymorphisms (SNPs) located on the flanking 3'UTR region were investigated by TaqI polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and HhaI forced PCR-RFLP in a sample of 1,019 individuals from four Chinese indigenous goat breeds. In the TaqI and HhaI analyses, the frequencies of allele T 2 and H 2 in Xinong Sannen dairy (XNSN dairy) and Guanzhong dairy (GZ dairy) populations were significantly greater than those of Shanbei White Cashmere (SBWC) and Xinjiang White Cashmere (XJWC) goats, respectively. Relationships analyses between the two SNPs and milk performance traits and growth traits were performed. T 2 T 2 animals had significantly greater milk yield, protein and solids-not-fat percentage than those with the T 1 T 1 genotype. Thus, weaver/TaqI polymorphism appears to be a promising marker to improve milk production traits in goat.

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“…We previously reported that one SNP located on exon 4 was associated with milk yield (P = 0.045) (Li et al, 2010). However, no difference was found in milk composition (P > 0.05).…”

Section: Resultsmentioning

confidence: 91%

Weaver gene 3'UTR novel mutations: Associations with production traits and milk composition in dairy goat

Li¹

2011

Afr. J. Biotechnol.

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“…The identification of genomic variation is a main step for understanding the relationship between genotype and phenotype. Single nucleotide polymorphisms (SNPs) showed potential as molecular markers to link genotypes with desired traits in goats, such as milk quality and quantity [5][6][7], litter size [8,9], growth rate [8,10], fiber quality [11][12][13] and disease resistance [14].…”

Section: Introductionmentioning

confidence: 99%

Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection

Aboshady¹,

Mandonnet²,

Johansson³

et al. 2019

Preprint

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Background Gastrointestinal nematodes (GIN) are an important constraint in grazing small ruminant production. Genetic selection for resistant animals is a potential sustainable control strategy. Advances in molecular genetics have led to the identification of several molecular genetic markers associated with genes affecting economic relevant traits.Results In this study, the variants in the genome of Creole goats resistant or susceptible to GIN were discovered from RNA-sequencing. We identified SNPs, insertions and deletions that distinguish the two genotypes, resistant and susceptible and we characterized these variants through functional analysis. The T cell receptor signalling pathway was one of the top significant pathways that distinguish the resistant from the susceptible genotype with 78% of the genes involved in this pathway showing genomic variants.Conclusions These genomic variants are expected to provide useful resources especially for molecular breeding for GIN resistance in goats.

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“…Single nucleotide polymorphism (SNP) markers can be documented to link genotypes to functional phenotypes of interest ( Liao and Lee, 2010 ). Several studies have shown SNPs have potential as molecular markers for cashmere fiber quality ( Lan et al, 2009 ; Zhou et al, 2011 ; Wang et al, 2012 ), milk traits ( Li et al, 2010 ; Hou et al, 2013 ; Zhao et al, 2013 ; Hou et al, 2014 ), litter size ( Chu et al, 2011 ) and growth traits ( Cai et al, 2014 ) in goats. Traditionally, SNP discovery is achieved through comparing sequences of candidate genes or other genomic regions from a number of representative lines or individuals.…”

Section: Introductionmentioning

confidence: 99%

SNP Discovery from Transcriptome of Cashmere Goat Skin

Wang¹,

Zhang²,

Zhao³

et al. 2015

Asian Australas. J. Anim. Sci

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The goat Capra hircus is one of several economically important livestock in China. Advances in molecular genetics have led to the identification of several single nucleotide variation markers associated with genes affecting economic traits. Validation of single nucleotide variations in a whole-transcriptome sequencing is critical for understanding the information of molecular genetics. In this paper, we aim to develop a large amount of convinced single nucleotide polymorphisms (SNPs) for Cashmere goat through transcriptome sequencing. In this study, the transcriptomes of Cashmere goat skin at four stages were measured using RNA-sequencing and 90% to 92% unique-mapped-reads were obtained from total-mapped-reads. A total of 56,231 putative SNPs distributed among 10,057 genes were identified. The average minor allele frequency of total SNPs was 18%. GO and KEGG pathway analysis were conducted to analyze the genes containing SNPs. Our follow up biological validation revealed that 64% of SNPs were true SNPs. Our results show that RNA-sequencing is a fast and efficient method for identification of a large number of SNPs. This work provides significant genetic resources for further research on Cashmere goats, especially for the high density linkage map construction and genome-wide association studies.

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Two novel cSNPs of weaver gene in Chinese indigenous goat and their associations with milk yield

Cited by 10 publications

References 23 publications

Weaver gene 3'UTR novel mutations: Associations with production traits and milk composition in dairy goat

Weaver gene 3'UTR novel mutations: Associations with production traits and milk composition in dairy goat

Genomic variants from RNA-seq for goats resistant or susceptible to gastrointestinal nematode infection

SNP Discovery from Transcriptome of Cashmere Goat Skin

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