Two Novel Iridoids from <i>Morinda longifolia</i>

Nk, Ban; Vh, Giang; Tm, Linh; Q, Lien le; Nt, Ngoc; D, Dat le; Np, Thao; Nx, Nhiem; Nx, Cuong; C, Van Pham; Regalado, Jacinto C.; H, Van Keo; P, Van Kiem; C, Van Minh

doi:10.1177/1934578x1400900702

Cited by 4 publications

(1 citation statement)

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“…This seems to be the first report on the isolation of the flavonoid glycosides quercetin-3- O - β -glucopyranoside ( 11 ) and kaempferol 3- O - α -L-rhamnopyranoside-7- O - α -L-rhamnopyranoside ( 12 ) from a plant of the Psychotria genus although these secondary metabolites have already been found in the family Rubiaceae, precisely in Hedyotis diffusa and Hedyotis verticillata , respectively [ 31 ]. The iridoid borreriagenin ( 13 ) obtained during this work has already been isolated from some plants of the Rubiaceae family including Borreria verticillata [ 21 ] and Morinda longifolia [ 37 ], but to the best of our knowledge, this is the first report of its isolation from a plant of the genus Psychotria .…”

Section: Discussionmentioning

confidence: 99%

Chemotaxonomy and Antibacterial Activity of the Extracts and Chemical Constituents of Psychotria succulenta Hiern. (Rubiaceae)

Jouogo

Tamokou

Teponno

et al. 2022

BioMed Research International

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The use of natural products for medicinal purposes is becoming more and more common nowadays, as evidenced by the presence in plants of secondary metabolites with different potentials such as antioxidant and antibacterial properties. We evaluated in this work the antimicrobial activities of the extracts and some isolated compounds from the seeds of Psychotria succulenta Hiern. (Rubiaceae), a Cameroonian medicinal plant traditionally used to cure microbial infections. The ethanol extract was prepared by maceration and extracted with ethyl acetate and n-butanol. The EtOAc ( m = 168 g ) and n-BuOH ( m = 20 g ) extracts were further fractionated by silica gel column chromatography to isolation of compounds. Their structures were elucidated by spectroscopic analysis and by comparison with published data. The antibacterial activity of extracts and compounds was assessed by evaluating the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against pathogenic bacteria. Thirteen compounds including four alkaloids (veprisine (1), naucleofficine III (2), vepridimerine B (3), and vepridimerine C (4)), three triterpenes (barbinervic acid (5), 3-O-α-L-rhamnopyranosyl quinovic acid (6), and oleanolic acid (7)), one steroid (β-sitosterol-3-O-β-D-glucopyranoside (8)), four phenolic compounds (scopoletin (9), gallic acid (10), quercetin-3-O-β-D-glucopyranoside (11), and kaempferol 3-O-α-L-rhamnopyranoside-7-O-α-L-rhamnopyranoside (12)), and one iridoid (borreriagenin (13)) were isolated from the EtOAc and n-BuOH extracts. These compounds were identified by 1D and 2D NMR combined analysis as well as by melting point comparison. The EtOH, EtOAc, and n-BuOH extracts exhibited significant antibacterial activities ( MIC = 32 ‐ 128 μ g / mL ; MBC = 64 ‐ 256 μ g / mL ) against Staphylococcus aureus (Gram-positive bacterium), Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumonia (Gram-negative bacteria). Among the isolated compounds, scopoletin (9) showed a moderate activity against Klebsiella pneumoniae with MIC and MBC values of 16 μg/mL and 32 μg/mL, respectively. It appears that, chemotaxonomically, some of the isolated compounds have already been obtained from the genus Psychotria but to the best of our knowledge, this is the first report on the phytochemical investigation of P. succulenta. Although many other studies need to be achieved, our results support the use of P. succulenta in traditional medicine to cure infectious diseases particularly those caused by the tested bacteria.

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Section: Discussionmentioning

confidence: 99%