2020
DOI: 10.3390/toxins12090529
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Two Novel Peptide Toxins from the Spider Cyriopagopus longipes Inhibit Tetrodotoxin-Sensitive Sodium Channels

Abstract: Sodium channels play a critical role in the generation and propagation of action potentials in excitable tissues, such as nerves, cardiac muscle, and skeletal muscle, and are the primary targets of toxins found in animal venoms. Here, two novel peptide toxins (Cl6a and Cl6b) were isolated from the venom of the spider Cyriopagopus longipes and characterized. Cl6a and Cl6b were shown to be inhibitors of tetrodotoxin-sensitive (TTX-S), but not TTX-resistant, sodium channels. Among the TTX-S channels investigated,… Show more

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Cited by 6 publications
(2 citation statements)
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“…Site 3 toxins, like α-toxins (from scorpion, spider and sea anemone), slow fast inactivation and bind to the S3–S4 extracellular loop in domain IV ( Thomsen and Catterall 1989 ; Catterall et al, 2007 ). Site 4 peptide toxins (β-toxins) regulate activation kinetics by binding to the extracellular loop connecting the S3-S4 segments in DII ( Catterall et al, 2007 ; Xiao et al, 2008 ; Song et al, 2011 ; Zhang et al, 2020 ). It is known that the central pore of Na v channel-mediated ion flow and the DII VSD is associated with channel activation and the DIV VSD is responsible for fast inactivation of channels.…”
Section: Introductionmentioning
confidence: 99%
“…Site 3 toxins, like α-toxins (from scorpion, spider and sea anemone), slow fast inactivation and bind to the S3–S4 extracellular loop in domain IV ( Thomsen and Catterall 1989 ; Catterall et al, 2007 ). Site 4 peptide toxins (β-toxins) regulate activation kinetics by binding to the extracellular loop connecting the S3-S4 segments in DII ( Catterall et al, 2007 ; Xiao et al, 2008 ; Song et al, 2011 ; Zhang et al, 2020 ). It is known that the central pore of Na v channel-mediated ion flow and the DII VSD is associated with channel activation and the DIV VSD is responsible for fast inactivation of channels.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, it manifests quite interesting biological activity, promoting neurite outgrowth through the NGF/TrkA signaling pathway. Two new toxins inhibiting tetrodotoxin-sensitive sodium channels are isolated from the venom of the spider Cyriopagopus longipes and characterized [8]. Among several sodium channels investigated, the toxins showed the highest activity against NaV1.7 subtype.…”
mentioning
confidence: 99%