2024
DOI: 10.1021/acsomega.3c06348
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Two Novel Regioisomeric Series of Bis-pyrazolines: Synthesis, In Silico Study, DFT Calculations, and Comparative Antibacterial Potency Profile against Drug-Resistant Bacteria; MSSA, MRSA, and VRSA

Refaie M. Kassab,
Magdi E. A. Zaki,
Sami A. Al-Hussain
et al.

Abstract: Aims: Design and synthesis of antimicrobial prototypes that are capable of eradicating bacterial biofilm formation that is responsible for many health challenges particularly with antibioticresistant bacterial species. Materials and Methods: The utility of 1,3diarylenones, aka chalcones, 3a−i and 8a−j as building blocks to construct the corresponding bis-pyrazoline derivatives 5aa-bh and 9ad-bj. Screening the antibacterial behavior of the novel bispyrazoline derivatives against methicillin-sensitive Staphyloco… Show more

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