Two Novel Sesquiterpene Lactones, Cytotoxic Vernolide-A and -B, from Vernonia cinerea.

Kuo, Yao‐Haur; Kuo, Yu‐Jen; Yu, Ang-Su; Wu, Ming-Der; Ong, Chi Wi; Kuo, Li Jen; Huang, Jo-Ti; Chen, Chieh-Fu; Li, Shyh-Yuan

doi:10.1248/cpb.51.425

Cited by 67 publications

(42 citation statements)

References 5 publications

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“…Because of the strong presence of sesquiterpene lactones in this fraction, it was selected to perform this study. Acetylated sesquiterpene lactones are commonly found in Vernonia species (Kuo et al, 2003). The subfraction used in this experiment, SF2125, was obtained from DCM fraction, confirms the toxic properties of these compounds.…”

Section: Discussionsupporting

confidence: 71%

“…The fact of the intravenous treatment did not reduce the ascitic tumor volume, suggest that some enzymatic route could be deactivating the systemic via, according with previous results, where mice treated by oral via with DCM fraction of V. scorpioides did not reduce Ehrlich´s ascitic or solid tumor (Pagno et al, 2006). Among the Vernonia species, some cytotoxicity has been described for isolated sesquiterpene lactones from V. cinerea (Kuo et al, 2003) and V. lasiopus (Koul et al, 2003). Vernonia Cytotoxic activity of the sub-fraction 2125 from Vernonia scorpioides against Sarcoma 180 tumor cells in mice scorpioides has been studied in different biological tests and has shown cytotoxic effects in most of these.…”

Section: Discussionmentioning

confidence: 58%

“…Pers., Asteraceae, popularly known as Piracá, Enxuga or Erva-de-São-Simão in Portuguese, is very common in Brazil, and usually grows in poor and deforested neotropical soils (Cabrera,1980). The genus Vernonia produces characteristic compounds such as sesquiterpene lactones, with several reported biological activities, such as fungistatic (Krishna Kumari et al, 2003), and cytotoxic activities (Kuo et al, 2003). Previous studies of the Vernonia scorpioides crude extract have shown moderate bactericide activity and mild wound healing effects (Leite et al, 2002;Biavatti et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic activity of the sub-fraction 2125 from Vernonia scorpioides against Sarcoma 180 tumor cells in mice

Kreuger¹,

Biavatti²,

Pacheco³

et al. 2009

Rev. bras. farmacogn.

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RESUMO: "Ação citotóxica da sub-fração 2125 de Vernonia scorpioides contra células do Sarcoma 180 em camundongos". O efeito da sub-fração SF-2125 obtida do extrato das folhas de Vernonia scorpioides foi investigado em camundongos portadores do tumor ascítico Sarcoma 180 (S180). Os animais foram tratados com SF-2125 na concentração de 5 mg/kg, administrada por vias intraperitoneal e intravenosa durante o desenvolvimento do tumor. O tratamento com SF-2125 5 mg/kg i.p. aumentou o tempo de vida dos animais, manteve seu peso corporal e o tumor na forma ascítica não teve desenvolvimento. O tratamento intravenoso não reduziu o volume do tumor. Unitermos: Sarcoma 180, sub-fração 2125, Vernonia scorpioides.ABSTRACT: The effect of the selected sub-fraction SF-2125 of the Vernonia scorpioides leaf extract on Sarcoma 180 (S180) ascitic tumor-bearing mice was investigated. The animals were treated with SF-2125 at a concentration of 5 mg/kg, administered intraperitoneally and intravenous during the development of the tumor. Treatment with SF-2125 5 mg/kg i.p. increased the lifespan of the animals, maintained their body and the ascitic tumor showed no development. Intravenous treatment did not reduce the tumor volume.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

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Cytotoxic activity of the sub-fraction 2125 from Vernonia scorpioides against Sarcoma 180 tumor cells in mice

Kreuger¹,

Biavatti²,

Pacheco³

et al. 2009

Rev. bras. farmacogn.

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“…The genus Vernonia produces characteristic compounds such as sesquiterpene lactones, with several reported biological activities, such as fungistatic (14), and cytotoxic activities (15,16) and also acts as a smooth muscle relaxant (17). Some other compounds have been isolated from Vernonia, such as flavonoids (18), steroids (19) and polysaccharides (20).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic activity of the dichloromethane fraction from Vernonia scorpioides (Lam.) Pers. (Asteraceae) against Ehrlich's tumor cells in mice

Pagno

Blind

Biavatti

et al. 2006

Braz J Med Biol Res

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Vernonia scorpioides has been widely used in Brazil to treat skin problems and chronic wounds, such as ulcers of the lower limbs and diabetic lesions. In the present study, we investigated the effect of a dichloromethane (DCM) fraction of V. scorpioides leaf extract on Ehrlich ascitic and solid tumor-bearing mice. The animals were treated once a day with the DCM fraction at a concentration of 5 mg/kg, administered ip during and after the development of the tumor. The lifespan, weight, number and type of leukocytes, number of tumor cells, volume of solid and ascitic tumors were measured. The development of the tumor with pre-treated tumor cells in vitro with the DCM fraction (5 mg/kg) was analyzed and the animals were sacrificed after 7 days. The DCM fraction (5 mg/kg) totally inhibited tumor development when in direct contact with tumor cells, and also ascitic tumor development with in vitro treatment or when administered ip, in loco (after 7 days). Animals treated with the DCM fraction increased their lifespan ca. 2 weeks and maintained their body weight for 30 days. When applied immediately after the inoculation of the tumor cells in vivo, it totally abolished tumor development, with tumor development only decreasing when treatment was started 3 days after the tumor challenge. These data suggest an antineoplastic activity of the fraction. Oral or ip administration of DCM fraction (5 mg/kg) for 7 days did not reduce the solid tumor volume. The cytotoxic activity described here differs from the conventional immune suppressing profile of standard chemotherapy because it increases neutrophil influx to the peritoneal cavity. These results show that, besides exhibiting a tumoricidal activity, the DCM fraction also exhibits inflammatory activity.

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“…17 Literature evidences reveal that the root decoction and stem of V. cinerea have been used in the treatment of diabetes mellitus and human breast cancer. 18,19 The bark juice of V. arborea is used for treating worms and chewed on the first signs of sprue in southern Sumatra. 20 The plant also has a very good antifungal activity due to the presence of a sesquiterpene Zaluzanin D. 21 Leaf juice is used to treat worms; decoction of bark in fever, leaf extract is also used for treating septic wounds, jaundice fever, wound healing and rheu matic pains.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory screening of ethanolic leaf extract of Vernonia arborea Buch. –Ham.in formalin induced albino wistar rats

Sridharan¹,

Venkatramani²,

Janakiraman³

et al. 2016

IJPER

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Context:The therapeutic potential of the genus Vernonia has been well documented over the years. However the pharmacological potential of the plant Vernonia arborea (Asteraceae) has been relatively less explored. Objective: To investigate the antiinflammatory effect of the ethanol leaf extract of V. arborea against formalin induced inflammation in rats. Materials and methods: Formalin induced inflammation method was used to induce inflammation in rats.0.1 ml/kg body weight (b.w.) of formalin was administered to the rats via sub-plantar injection to induce inflammation. The rats were pretreated with ethanol leaf extract of V. arborea at concentrations of 100, 200 and 300 mg/kg b.w. once daily for 30 days. Indomethacin (25 mg/kg b.w.) was used as standard drug. Biochemical and hematological parameters along with levels of antioxidant enzymes were evaluated. Results: Administration of formalin reduced antioxidant enzyme levels, total RBC and Hb. Pretreatment with ethanol leaf extract of V.arborea at dose dependent levels significantly increased (p<0.05)the levels of the above parameters. A significant increase (p<0.05) in paw thickness, level of serum enzymes (Aspartate transaminase, Alanine transaminase, Alkaline phosphatase and Creatine kinase), Lipid peroxide and leucocytes was observed in the rats induced with formalin, while these levels were normalized on pretreatment with ethanol leaf extract of V.arborea. Conclusion: The results of the present investigation demonstrate the antioxidant and anti-inflammatory potential of the ethanol leaf extract of V.arborea. However, it is imperative to isolate and purify the active principles involved in the pharmacological potency of this plant and determine its mechanism of action.

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Two Novel Sesquiterpene Lactones, Cytotoxic Vernolide-A and -B, from Vernonia cinerea.

Cited by 67 publications

References 5 publications

Cytotoxic activity of the sub-fraction 2125 from Vernonia scorpioides against Sarcoma 180 tumor cells in mice

Cytotoxic activity of the sub-fraction 2125 from Vernonia scorpioides against Sarcoma 180 tumor cells in mice

Cytotoxic activity of the dichloromethane fraction from Vernonia scorpioides (Lam.) Pers. (Asteraceae) against Ehrlich's tumor cells in mice

Anti-inflammatory screening of ethanolic leaf extract of Vernonia arborea Buch. –Ham.in formalin induced albino wistar rats

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