Two novel steroidal derivatives from chloroform-soluble extract of <i>Hoya longifolia</i>

Srivastava, Pawan Kumar; Gupta, M.; Khare, Naveen K.

doi:10.1080/14786419.2015.1052066

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…Naturally occurring terpenoids, functionalized terpene derivatives, are not just a structural curiosity, but play a central role in medicinal chemistry [1,3]. Their biological activity can range from anti-tumor activity to effects on cardiovascular systems (cardiac glycosides) to anti-inflammation [4][5][6][7][8][9]. Due to these far ranging biological activities, the hydrindane scaffolds often become the target for development into drug-like molecules for the treatment of disease [10,11].…”

Section: Introductionmentioning

confidence: 99%

Methodology for the Construction of the Bicyclo[4.3.0]nonane Core

Eddy

Ichalkaranje

2016

Molecules

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Abstract:The bicyclo[4.3.0]nonane scaffold, commonly known as a hydrindane, is a common structural motif found in many terpenoid structures and one that remains a challenge for synthetic chemists to elaborate with appropriate regio-and stereo-selectivity. Over the course of the study of terpene natural products, the elaboration of the hydrindane structure has seen progress on the utilization of both old and newer methods to achieve the desired outcomes. This review seeks to serve as a general overview of these methods, and detail specific examples.

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Section: Introductionmentioning

confidence: 99%

Methodology for the Construction of the Bicyclo[4.3.0]nonane Core

Eddy

Ichalkaranje

2016

Molecules

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Isolation and identification of two novel compounds from Marsdenia roylei and their quantum chemical calculations

Gupta

Kumar

Khare

2016

Natural Product Research

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Two new compounds 1 (Methyl 26-di-deoxy-6-methyl-β-D-allohexopyranoside) and 3 (3, 11, 12, 20 tetra-O-acetyl-pregn-5-ene-14β-ol) have been isolated from the chloroform-soluble extract of the whole plant of Marsdenia roylei (family: Asclepiadaceae) and their structures were determined by 1D, 2D NMR and ESI-MS as well as by chemical modification. We have calculated the molecular geometries, local reactivity descriptors by the density functional theory with B3LYP functional with basis set 6-311G+(d,2p) of 1, 3 and 4 (deacylated 3). The H andC NMR chemical shifts of 1, 3 and 4 were calculated using Gauge-Including Atomic Orbital approach and these values are correlated with the experimental observations.

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Two novel steroidal derivatives from chloroform-soluble extract of Hoya longifolia

Cited by 2 publications

References 30 publications

Methodology for the Construction of the Bicyclo[4.3.0]nonane Core

Methodology for the Construction of the Bicyclo[4.3.0]nonane Core

Isolation and identification of two novel compounds from Marsdenia roylei and their quantum chemical calculations

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