Two Offset Printing Workers with Cholangiocarcinoma

Kumagai, Shinji

doi:10.1539/joh.13-0262-cs

Cited by 15 publications

(7 citation statements)

References 14 publications

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“…The estimated exposure concentrations of 1,2-DCP during the ink removal operation were 150−620 ppm, and the shift TWAs were 62−240 ppm, which were similar levels of exposure to those at the Osaka printing plant. For Subject C, Kumagai previously reported the estimated working environment concentration of 1,2-DCP to be 36 ppm using the well-mixed model 11) , which is nearly equal to the current estimated values (17−58 ppm, Table 2). Assuming that the exposure concentration was twice that of the working environment concentration, Kumagai also reported an estimated exposure concentration of 72 ppm 11) , which is within the range of the current estimated values (62−170 ppm, Table 2).…”

Section: Discussionsupporting

confidence: 59%

Chemical Exposure Levels in Printing Workers with Cholangiocarcinoma

Yamada

Kumagai

Nagoya

et al. 2014

Journal of Occupational Health

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Section: Discussionsupporting

confidence: 59%

Chemical Exposure Levels in Printing Workers with Cholangiocarcinoma

Yamada

Kumagai

Nagoya

et al. 2014

Journal of Occupational Health

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“…Other solvents, such as dichloromethane and 1,1,1-trichloroethane, were also components used in the cleaner at different periods of time. However, 1,2-DCP was the only chemical that coincided with the occurrence of all cholangiocarcinoma cases, either as a single solvent or in a mixture with dichloromethane or 1,1,1-trichloroethane (Kumagai, 2014). The large quantities of 1,2-DCP used and the high rate of evaporation of 1,2-DCP, as well as the poor ventilation in the facilities, resulted in high concentrations of this solvent in workplaces, as demonstrated in an experiment that reproduced the working environment of the proof-printing room in that factory (Ministry of Health, Labour and Welfare, Japan, 2012, 2013b).…”

Section: Introductionmentioning

confidence: 99%

Cytochrome P450 2E1 is responsible for the initiation of 1,2-dichloropropane-induced liver damage

et al. 2016

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1,2-Dichloropropane (1,2-DCP), a solvent, which is the main component of the cleaner used in the offset printing companies in Japan, is suspected to be the causative agent of bile duct cancer, which has been recently reported at high incidence in those offset printing workplaces. While there are some reports about the acute toxicity of 1,2-DCP, no information about its metabolism related to toxicity in animals is available. As part of our efforts toward clarifying the role of 1,2-DCP in the development of cancer, we studied the metabolic pathways and the hepatotoxic effect of 1,2-DCP in mice with or without cytochrome P450 2E1 (CYP2E1) activity. In an in vitro reaction system containing liver homogenate, 1,2-DCP was only metabolized by liver tissue of wild-type mice but not by that of cyp2e1-null mice. Furthermore, the kinetics of the solvent in mice revealed a great difference between the two genotypes; 1,2-DCP administration resulted in dose-dependent hepatic damage, as shown biochemically and pathologically, but this effect was only observed in wild-type mice. The nuclear factor κB p52 pathway was involved in the liver response to 1,2-DCP. Our results clearly indicate that the oxidative metabolism of 1,2-DCP in mice is exclusively catalyzed by CYP2E1, and this step is indispensable for the manifestation of the hepatotoxic effect of the solvent.

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“…Although some companies mistakenly consider 1,2-DCP to be an eco-friendly industrial detergent, the chemical is known to cause hepatic and renal dysfunction, inhibition of the central nervous system (CNS), hemolytic anemia, and thrombosis 1 , 2 , 3 , 4 ) . Many cases of cholangiocarcinoma occurred in workers at offset printing plants in Osaka, Japan, where 1,2-DCP was used in large quantities 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ) . The IARC designated 1,2-DCP as a group 1 carcinogen in 2014 13 ) .…”

Section: Introductionmentioning

confidence: 99%

Acute toxic encephalopathy induced by occupational exposure to 1,2-dichloropropane

et al. 2018

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1,2-Dichloropropane (1,2-DCP) is used widely in Korea as a substitute for trichloroethylene or methylene chloride. Some companies mistakenly consider that 1,2-DCP is an eco-friendly detergent because its use is not regulated, but 1,2-DCP is known to inhibit the central nervous system in animals; a few cases of accidental exposure have been reported in humans. We present a case of acute encephalopathy caused by exposure to 1,2-DCP. A 41 yr-old male presented with dizziness, headache, and diplopia after exposure to the detergent without protective equipment. Brain magnetic resonance imaging suggested metabolic encephalopathy, but the patient had no thiamine deficiency and no other metabolic disorder. As the symptoms had commenced after exposure to a large amount of solvent while skimming rust from the surface, and as the symptoms were more severe during the work week, improved on weekends, and disappeared after solvent exposure ceased, the toxic encephalopathy was likely induced by inhalation of the detergent.

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Two Offset Printing Workers with Cholangiocarcinoma

Abstract: Two Offset Printing Workers with Cholangiocarcinoma: Shinji KUMAGAI.

Cited by 15 publications

References 14 publications

Chemical Exposure Levels in Printing Workers with Cholangiocarcinoma

Chemical Exposure Levels in Printing Workers with Cholangiocarcinoma

Cytochrome P450 2E1 is responsible for the initiation of 1,2-dichloropropane-induced liver damage

Acute toxic encephalopathy induced by occupational exposure to 1,2-dichloropropane

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