Two pediatric cases of gastric adenocarcinoma and review of the literature

Abstract

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Pediatric Gastric Adenocarcinoma Presenting As Hip Pain

“…Our case presented with non-specific symptoms such as hip pain, with multiple metastases at the time of diagnosis. Interestingly, there is a case reported with a similar presentation [ 1 ]. There have been other presentations reported for pediatric gastric cancer including ascites and gastric outlet obstruction [ 13 , 14 ].…”

“…The chance of long-term survival in patients with gastric adenocarcinoma is only possible with total surgical resection of the tumor, but patients are not always candidates for surgery because of their widespread metastases during diagnosis [ 1 ]. Young people at risk of hereditary diffuse gastric cancer may benefit, however, from prophylactic gastrectomy [ 7 ].…”

“…Gastric adenocarcinoma is a rare diagnosis in children but it is the third deadliest cancer worldwide [ 1 ]. It constitutes 0.05% of all gastrointestinal cancers in childhood, and it accounts for only 5% of all pediatric neoplasms [ 2 , 3 ].…”

“…It constitutes 0.05% of all gastrointestinal cancers in childhood, and it accounts for only 5% of all pediatric neoplasms [ 2 , 3 ]. Patients with gastric adenocarcinoma commonly present with complaints of vomiting, abdominal pain, anemia, and weight loss [ 1 ]. The prognosis is poor in patients with metastasis at the time of diagnosis, with a mean survival of approximately three months [ 1 ].…”

“…Patients with gastric adenocarcinoma commonly present with complaints of vomiting, abdominal pain, anemia, and weight loss [ 1 ]. The prognosis is poor in patients with metastasis at the time of diagnosis, with a mean survival of approximately three months [ 1 ]. The exact cause of stomach cancer in children is still unknown, despite the knowledge that several environmental and genetic variables, in particular nutrition and lifestyle, are risk factors in adults [ 4 ].…”