Two Peptide Receptor Ligands 99mTc-EDDA/HYNIC-Tyr3-Octreotide and 99mTc-EDDA/HYNIC-DGlu-Octagastrin for Scintigraphy of Medullary Thyroid Carcinoma

Kosowicz, J; Mikołajczak, Renata; Czepczyński, Rafał; Ziemnicka, Katarzyna; Gryczyńska, Maria; Sowiński, Jerzy

doi:10.1089/cbr.2006.368

Cited by 15 publications

(13 citation statements)

References 26 publications

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“…Gastrin receptor scintigraphy seemed to have higher specificity and positive predictive value, but lower sensitivity than SRS. This could be related to peptide structure and purification [5].…”

Section: Opis Przypadkumentioning

confidence: 99%

“…Cholecystokinin-2/gastrin receptor (CCK2R) is overexpressed in most tumours, such as MTC (>90%), astrocytomas (> 65%), and stromal ovarian cancers (100%). In such cases, gastrin receptor scintigraphy gives a higher tumour detection rate than SRS [4,5]. Therefore, CCK2-scintigraphy parallel to SRS may improve the detection rate of MTC.…”

Section: Opis Przypadkumentioning

confidence: 99%

“…The presence of CCK-2 receptors was used for localising MTC and its metastases in different scintigraphic techniques. In some studies, gastrin receptor scintigraphy was used to enhance the sensitivity of SRS, especially in situations where the SRS scans were negative in the presence of advanced MTC or other neuroendocrine tumours [4,5,15]. Gastrin receptor scintigraphy seemed to have higher specificity and positive predictive value, but lower sensitivity than SRS.…”

Section: Opis Przypadkumentioning

confidence: 99%

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Rak rdzeniasty tarczycy — badanie PET/CT ze znakowanymi 68Ga analogami gastryny i somatostatyny

Kunikowska

Ziemnicka

Pawlak

et al. 2016

Endokrynologia Polska

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Case presentation: a 75-year-old man with a 10-year history of nodular goitre was referred for clinical evaluation. The ultrasound scan revealed enlarged thyroid right lobe almost fully filled with a heterogeneous nodule with numerous calcifications. Fine-needle aspiration biopsy suggested medullary thyroid carcinoma (MTC). Before the surgery the patient was referred to the nuclear medicine department and somatostatin receptor imaging (SRS; 68Ga-DOTATATE) with PET/CT was performed. The scan demonstrated an increased uptake within the right thyroid mass. Subsequent PET/CT with 68 Ga-gastrin analogue (MG48) revealed the same indications as the SRS: an increased alveolar uptake in the right thyroid mass without the signs of lymph node metastases. The patient underwent total thyroidectomy and central lymph nodes dissection. Histopathology examination confirmed the presence of MTC with vascular invasion, but without lymph node metastases (pT3NoMx according to the 7 th edition of the AJCC Cancer Staging Manual). Immunohistochemical staining revealed positive reaction to calcitonin and CD56, whereas the reaction to thyroglobulin remained negative. The Ki-67 was 1%. Staining for SSTR2 and CCK2 showed high cytoplasmic expression in both cases. Knowledge of the presence of CCK2 receptor in MTC patients may be an important indication for the choice of diagnostic and therapeutic procedures. The presence of both the receptor types, cholecystokinin-2/gastrin and somatostatin, is possibly an interesting combination as far as the therapeutic target is concerned. StreszczenieW pracy przedstawiono opis 75-letniego mężczyzny z dziesięcioletnią historią wola guzkowego skierowanego do Kliniki w celu badań kontrolnych. W badaniu USG stwierdzono powiększenie prawego płata tarczycy, wypełnionego prawie całkowicie niejednorodnym guzkiem z licznymi zwapnieniami. W biopsji aspiracyjnej cienkoigłowej wysunięto podejrzenie raka rdzeniastego tarczycy (MTC). Przed zabiegiem pacjenta skierowano do Zakładu Medycyny Nuklearnej w celu scyntygrafii receptorów somatostatynowych (SRS; 68 Ga-DOTATATE) wykonanej techniką PET/CT. W badaniu stwierdzono zwiększone gromadzenie znacznika w zmianie prawego płata tarczycy. Następnie wykonano badanie PET/CT z 68 Ga-analogiem gastryny(MG48), stwierdzając podobnie jak w SRS, zwiększone gromadzenie znacznika w guzku prawego płata tarczycy, nie stwierdzono przerzutów do węzłów chłonnych. Wykonano całkowite wycięcie tarczycy i centralnych węzłów chłonnych. Badanie histopatologiczne potwierdziło obecność MTC z cechami inwazji naczyniowej, ale bez przerzutów do węzłów chłonnych (pT3NoMx według 7. edycji AJCC stopnia złośliwości). Barwienie immunohistochemiczne ujawniło pozytywną reakcję na kalcytoninę i CD56, podczas gdy reakcja Tg była negatywna. Ki-67 wynosiło 1%. Barwienie na obecność receptorów SSTR2 oraz CCK2 wykazało wysokie poziomy ekspresji cytoplazmatycznej, w obu przypadkach. Znajomość obecności receptora CCK2 u pacjentów z MTC może być ważna w trakcie wyboru procedur diagnostycznych i terapeutycz...

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Section: Opis Przypadkumentioning

confidence: 99%

Section: Opis Przypadkumentioning

confidence: 99%

Section: Opis Przypadkumentioning

confidence: 99%

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Rak rdzeniasty tarczycy — badanie PET/CT ze znakowanymi 68Ga analogami gastryny i somatostatyny

Kunikowska

Ziemnicka

Pawlak

et al. 2016

Endokrynologia Polska

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“…Imaging of cholecystokinin 2/ gastrin receptors in human with medullary thyroid carcinoma [180] 99m Tc [HYNIC 0 ,DGlu 1 ,desGlu [2][3][4][5][6] minigastrin ( 99m Tc-HYNIC-MG11)…”

Section: Peptidementioning

confidence: 99%

Tumor targeting with ^99mTc radiolabeled peptides: Clinical application and recent development

Rezazadeh

Sadeghzadeh

2018

Chem Biol Drug Des

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Targeting overexpressed receptors on the cancer cells with radiolabeled peptides has become very important in nuclear oncology in the recent years. Peptides are small and have easy preparation and easy radiolabeling protocol with no side-effect and toxicity. These properties made them a valuable tool for tumor targeting. Based on the successful imaging of neuroendocrine tumors with 111 In-octreotide, other receptor-targeting peptides such as bombesin (BBN), cholecystokinin/gastrin analogues, neurotensin analogues, glucagon-like peptide-1, and RGD peptides are currently under development or undergoing clinical trials. The most frequently used radionuclides for tumor imaging are 99m Tc and 111 In for single-photon emission computed tomography and 68 Ga and 18 F for positron emission tomography imaging. This review presents some of the 99m Tc-labeled peptides, with regard to their potential for radionuclide imaging of tumors in clinical and preclinical application. K E Y W O R D S 99m Tc, radiolabeled peptides, SPECT, tumor targeting 206 | REZAZADEH AnD SADEGHZADEH some of them are currently under development or undergoing clinical trials. [13] Some of the most important peptides and their overexpressed receptors on tumors are listed in Table 1. 99m Tc is used for medical imaging in 80% of cases all over the world due to its near ideal nuclear characteristics of 6-hr half-life and γ-ray emission energy of 142 keV. Therefore, 99m Tc-labeled peptides with specific and high receptor affinity are very useful for tumor targeting. [14] The focus of this article remains the main applications of 99m Tc radiolabeled peptides in cancer research and development, which have been used in clinic and most promising candidates for future clinical use.

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“…11 C-5-HTP (hydroxytryptophan) have shown promising results in detection of NENs, but further studies are necessary to confirm its utility [45]. Medullary thyroid cancer has an ability to take up gastrin and CCK-2 analogs which can be potential tools for diagnostic approach in that malignancy [46,47].…”

Section: Other Nens Specific Tracersmentioning

confidence: 99%

NEN — the role of somatostatin receptor scintigraphy in clinical setting

Opalińska

Hubalewska‐Dydejczyk²,

Sowa‐Staszczak

et al. 2016

Nucl. Med. Rev.

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Detection of neuroendocrine neoplasms (NENs) and monitoring of their response to therapy is still challenging due to huge heterogeneity of that group of tumors. Actually, NENs visualization is mainly based on molecular imaging while in the past it was relied on less effective structural imaging including CT and MRI. Molecular imaging techniques in combination with structural imaging (hybrid imaging), especially in patients with well-differentiated NENs, in addition to morphological provide the functional information about tumor which benefits in a more accurate patient management, including more sensitive visualization of primary tumors, more precise staging and better therapy follow-up.Overexpression of somatostatin receptors (SSTR) on NENs' cell membrane was a basis for development of somatostatin receptor scintigraphy (SRS) using single photon emission tomography SPECT, which is today a well-established standard in molecular imaging of NENs, and further imaging improvement in the field of positron emission tomography (PET). Use of hybrid imaging (SPECT/CT, PET/CT) increased sensitivity of examination, mainly resulting in better detection of small lesions.

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Two Peptide Receptor Ligands ^99mTc-EDDA/HYNIC-Tyr³-Octreotide and ^99mTc-EDDA/HYNIC-_DGlu-Octagastrin for Scintigraphy of Medullary Thyroid Carcinoma

Cited by 15 publications

References 26 publications

Rak rdzeniasty tarczycy — badanie PET/CT ze znakowanymi 68Ga analogami gastryny i somatostatyny

Rak rdzeniasty tarczycy — badanie PET/CT ze znakowanymi 68Ga analogami gastryny i somatostatyny

Tumor targeting with ^99mTc radiolabeled peptides: Clinical application and recent development

NEN — the role of somatostatin receptor scintigraphy in clinical setting

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Two Peptide Receptor Ligands 99mTc-EDDA/HYNIC-Tyr3-Octreotide and 99mTc-EDDA/HYNIC-DGlu-Octagastrin for Scintigraphy of Medullary Thyroid Carcinoma

Cited by 15 publications

References 26 publications

Rak rdzeniasty tarczycy — badanie PET/CT ze znakowanymi 68Ga analogami gastryny i somatostatyny

Rak rdzeniasty tarczycy — badanie PET/CT ze znakowanymi 68Ga analogami gastryny i somatostatyny

Tumor targeting with 99mTc radiolabeled peptides: Clinical application and recent development

NEN — the role of somatostatin receptor scintigraphy in clinical setting

Contact Info

Product

Resources

About

Two Peptide Receptor Ligands ^99mTc-EDDA/HYNIC-Tyr³-Octreotide and ^99mTc-EDDA/HYNIC-_DGlu-Octagastrin for Scintigraphy of Medullary Thyroid Carcinoma

Tumor targeting with ^99mTc radiolabeled peptides: Clinical application and recent development