Entropy generation investigation of hybrid nanofluidic transport over an unsteady spinning disk is reported in this analysis. The magnetic influence, velocity slips, and thermal radiative effects are included within the flow. Ferrous oxide (Fe3O4) and graphene oxide (GO) are used as tiny nano ingredients, and water (H2O) is the base medium. The dimensional leading equations are settled to dimensionless nonlinear ordinary differential equations (ODEs) by significant similarity transformations. Then, classical RK-4 scheme with a shooting process has been initiated to execute the numerical simulation. The software MAPLE-18 is used to run the entire simulation with an indispensable accuracy rate. Several streamlines, graphs, and requisite tables are executed to divulge the parametric impact on the nanofluidic stream. Entropy generation–related figures are depicted for diverse parameters, and parametric effects on Bejan number are also analyzed. Moreover, the corresponding physical consignments like the measure of the frictional hindrance, heat transport are calculated and reviewed. The entropy generation augments for higher magnetic value but reduces for velocity slip, radiation, and nanoparticle concentration. Hybrid nanofluid gives a lower magnitude in entropy production as compared to the usual nanofluid. Magnetic parameter reduces the Bejan number, while slip factor and nanoparticle concentration amplify such effects. Heat transfer ultimately seems to increase for nanoparticle volume fraction, and the increase rate is 4.01685 for usual nanofluid, but it is 6.7557 for hybrid nanofluid. Also, the numerical fallouts address the possibility of using magnetized spinning disks in space engines and nuclear propulsion, and such a model conveys significant applications in heat transport improvement in so many industrial thermal management equipment and renewable energy systems.