Two Phenylpropanoid Glycosides from Neopicrorhiza scrophulariiflora

Kim, Ik Hwi; Kaneko, Noriko; Uchiyama, Nahoko; Lee, Ji Ean; Takeya, Koichi; Kawahara, Nobuo; Goda, Yukihiro

doi:10.1248/cpb.54.275

Cited by 16 publications

(7 citation statements)

References 6 publications

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“…Its molecular formula was determined to be C 28 3 The relatively large J value (6.9 Hz) of the anomeric proton (d 4.94) of glucose indicated that the anomeric configuration was b. The point of linkage of two sinapoyl moieties with the glucose was solved by analysis of the HMBC experiment, in which the cross peaks between H-1 0 (d 4.94) and C-4 (d 136.0), H-6 0 (d 4.25 and 4.17) and C-9 00 (d 166.6) were observed.…”

Section: Resultsmentioning

confidence: 99%

Two new compounds fromCynanchum amplexicaule

Chen¹,

Zhou²,

Liao³

et al. 2008

Journal of Asian Natural Products Research

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Section: Resultsmentioning

confidence: 99%

Two new compounds fromCynanchum amplexicaule

Chen¹,

Zhou²,

Liao³

et al. 2008

Journal of Asian Natural Products Research

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“…Up to now, there has been no detailed research on the extraction procedures for these chemical constituents. Generally, the crude extracts wer prepared with different concentrations of methanol, ethanol or acetone-water solution by the impregnation method, refluxing extraction or decoction method [10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,…”

Section: Chemical Constituentsmentioning

confidence: 99%

“…The 27 monosaccharide [16,18,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35] esters 1 – 10 , 21 – 27 represent the simplest structures found among CASEDs (Figure 1, Figure 2, Figure 3, Figure 4 and Figure 5). The main structural moiety of these compounds (Figure 2 and Figure 5), is a β- d -glucose ester, or an α- l -rhamnose ester in compounds 11 – 15 (Figure 3).…”

Section: Chemical Constituentsmentioning

confidence: 99%

Naturally Occurring Cinnamic Acid Sugar Ester Derivatives

Tian

Liu

et al. 2016

Molecules

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Cinnamic acid sugar ester derivatives (CASEDs) are a class of natural product with one or several phenylacrylic moieties linked with the non-anomeric carbon of a glycosyl skeleton part through ester bonds. Their notable anti-depressant and brains protective activities have made them a topic of great interest over the past several decades. In particular the compound 3 ,6-disinapoylsucrose, the index component of Yuanzhi (a well-known Traditional Chinese Medicine or TCM), presents antidepressant effects at a molecular level, and has become a hotspot of research on new lead drug compounds. Several other similar cinnamic acid sugar ester derivatives are reported in traditional medicine as compounds to calm the nerves and display anti-depression and neuroprotective activity. Interestingly, more than one third of CASEDs are distributed in the family Polygalaceae. This overview discusses the isolation of cinnamic acid sugar ester derivatives from plants, together with a systematic discussion of their distribution, chemical structures and properties and pharmacological activities, with the hope of providing references for natural product researchers and draw attention to these interesting compounds.

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“…In Nepal, a number of ethnobotanical uses of its unprocessed rhizomes have well been documented to treat common cold, fever, sinusitis, headache, diarrhea, paralysis, hysteria, anemia, high blood pressure, sore throat, gastritis, intestinal pains, snake and scorpion sting, abdominal pain, indigestion, liver troubles, bile disorders, continuous pain in the chest and heart, increased heartbeat, difficulty in breathing, jaundice, cuts, wounds, and conjunctivitis [ 10 – 18 ]. Chemical constituents of rhizomes of Neopicrorhiza are well studied which comprise iridoid glycosides [ 19 – 21 ], triterpenoids [ 22 ], phenolic glycosides [ 23 ], phenylethanoid glycosides [ 24 ], cucurbitacin glycoside [ 25 , 26 ], and phenylpropanoid glycosides [ 27 ] having a wide range of biological activities.…”

Section: Introductionmentioning

confidence: 99%

Demand, End‐Uses, and Conservation of Alpine Medicinal Plant Neopicrorhiza scrophulariiflora (Pennell) D. Y. Hong in Central Himalaya

Kafle

(Sharma)

Siwakoti

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Neopicrorhiza scrophulariiflora (Pennell) D. Y. Hong of Scrophulariaceae family (hereinafter referred to as Neopicrorhiza) has medicinally important rhizomes with high levels of trade. What factors drive demand for Neopicrorhiza in Central Himalaya is unknown. In this context, a nationwide comprehensive survey was conducted from September 2016 to March 2017 to assess demand, end-uses, and conservation of dry Neopicrorhiza rhizomes in Nepal. A total of 2313 herbal products were surveyed for Neopicrorhiza as an ingredient in 38 retailer shops. Processing industries of Neopicrorhiza in Nepal were interviewed using structured questionnaire. There were 23 herbal industries manufacturing 45 types of ayurvedic medicines as end-products containing Neopicrorhiza. The volume and value of annual demand for dry rhizomes of Neopicrorhiza in Nepal were found as 6076 kg and NRs 8573236 (USD 83235.30), respectively, in 2015/016 with average 264.17 kg/industry and NRs 1410.87 (USD 13.69) per kg. The major uses of ayurvedic medicines containing Neopicrorhiza were to treat a number of disease categories: cardiovascular system/liver (17), cardiovascular system/blood (6), nervous system (6), dermatological system (4), musculoskeletal system (3), digestive system (2), respiratory system (2), genitourinal system (4), and others (1). Despite changing legal regulation, trade and consumption of Neopicrorhiza exist in Nepal. It can be concluded that domestic consumption is not the major cause of resource depletion of Neopicrorhiza in Nepal.

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Two Phenylpropanoid Glycosides from Neopicrorhiza scrophulariiflora

Abstract: Neopicrorhiza scrophulariiflora (PENNELL) HONG (basionym. Picrorhiza scrophulariiflora PENNELL) is distributed throughout the high altitude (Ͼ4400 m) regions in southeastern Tibet and the northwestern Yunnan Province of China.

Cited by 16 publications

References 6 publications

Two new compounds fromCynanchum amplexicaule

Two new compounds fromCynanchum amplexicaule

Naturally Occurring Cinnamic Acid Sugar Ester Derivatives

Demand, End‐Uses, and Conservation of Alpine Medicinal Plant Neopicrorhiza scrophulariiflora (Pennell) D. Y. Hong in Central Himalaya

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