Two-photon absorption-based delivery of nitric oxide from ruthenium nitrosyl complexes

Abstract

Since the discovery of the numerous physiological roles exhibited by nitric oxide (NO), ruthenium nitrosyl (RuNO) complexes have been regarded as one of most promising NO donors, stable, well tolerated...

Insight into novel anti-mucormycosis therapies: investigation of new anti-mucormycosis laser-induced photodynamic therapy based on a sulphone bis-compound loaded silica nanoemulsion

“…The studied optical properties verified that, SBDMP -loaded silica nanoemulsion exhibits very deep penetration into biological tissues due to the TAP mechanism. 42,43 This directs the study to the fact that the liberation of ROS inside the cell is considered to be the dominant influence in this phenomenon, as it will be studied in detail in the following.…”

“…TPA is based on substituting the one-photon absorption (OPA) from the ground state to an excited state in one step via two absorption steps concurrently throughout the lifetime of the rst excited state. 42,43 In addition to its limited destroying effects, perfect regional selectivity, enhanced LIPDT, and deep penetration into biological tissues, TPA has become an effective strategy in life sciences. [42][43][44][45] 3.3.2.…”

“…42,43 In addition to its limited destroying effects, perfect regional selectivity, enhanced LIPDT, and deep penetration into biological tissues, TPA has become an effective strategy in life sciences. [42][43][44][45] 3.3.2. PL characterization.…”

“…The studied optical properties veried that, SBDMPloaded silica nanoemulsion exhibits very deep penetration into biological tissues due to the TAP mechanism. 42,43 This directs the study to the fact that the liberation of ROS inside the cell is considered to be the dominant inuence in this phenomenon, as it will be studied in detail in the following. Opportunistic fungi such as Mucorales strains still exhibit a signicant medical hindrance due to their high infection rates among immunocompromised patients as a result of their rapid proliferation and remarkable resistance to classical broadspectrum antibiotics.…”

A Trojan horse approach for enhancing the cellular uptake of a ruthenium nitrosyl complex

“…Our research group has been actively involved in the development of RuNO complexes that can be activated using the two-photon absorption technique, which allows the efficient photorelease of NO • under near-infrared (NIR) excitation. 34,35 While significant advances have provided us with highly photoreactive systems that deliver biologically relevant amounts of NO • , 36,37 the question of whether such highly polar and relatively large molecules are efficiently incorporated by cells remains unanswered. In this context, we decided to investigate the influence of attaching a biological recognition fragment on the cellular uptake efficiency of a RuNO complex.…”