Two Pink Nodules in a Patient with Acute Myeloid Leukemia

Bird, Jayne; Telang, Gladys H.; Robinson‐Bostom, Leslie

doi:10.1111/cup.12337

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…(b) PCM involving immunocompetent patients: This typically arises after fungal traumatic implantation; trauma is mostly due to traffic accidents and farm working accidents. To a lesser proportion, trauma can be related to natural disasters-e.g., tornado, hurricane, and volcanic eruption-domestic accidents, animal and insect bites, explosions, and burns [13,14,48 [59,60], papules and vesicles [14,61], abscesses, erythemanodosum-like lesions [62], panniculitis [63], verrucous plaques [24], chronic erythematous, and scaly plaques (simulating tinea corporis or Majocchi granuloma) [23]. Mucorales may colonize wounds of burned patients and chronic ulcers, similarly to Aspergillus spp., developing a moldy appearance [29•, 48••]; furthermore, some cases may be secondary to minor trauma or even develop [8•, 64, 65].…”

Section: Clinical Aspectsmentioning

confidence: 99%

Cutaneous Mucormycosis: Mycological, Clinical, and Therapeutic Aspects

Bonifáz

Tirado‐Sánchez

Calderón

et al. 2015

Curr Fungal Infect Rep

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Cutaneous mucormycosis (CM) is caused by ubiquitous filamentous fungi belonging to the order Mucorales. It is a rare, emerging mycosis, with increasing incidence since the last two decades, only surpassed by rhinocerebral and pulmonary mucormycosis. CM can be further classified in primary and secondary clinical forms. Primary cases can be seen on immunocompetent patients, frequently due to traumatic injuries, while in immunocompromised patients (those with diabetes mellitus or hematologic malignancies), lesions can arise at catheter insertion sites or after the use of contaminated adhesive tapes. Clinical features of primary cutaneous mucormycosis (PCM) are necrosis, followed by ulceration, generally associated to good prognosis. Secondary cutaneous mucormycosis (SCM) is related to rhinocerebral and/or disseminated forms. SCM usually starts as a palpebral fistula, as an erythematous area that rapidly evolves to necrosis and ulceration, related to worse prognosis. Direct examination, cultures, skin biopsies, and molecular tests are performed to diagnose both clinical forms. Liposomal amphotericin B (LAmB) in combination with surgical debridement constitutes the treatment of choice; however, for SCM, the addition of posaconazole or caspofungin is recommended.

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Section: Clinical Aspectsmentioning

confidence: 99%

Cutaneous Mucormycosis: Mycological, Clinical, and Therapeutic Aspects

Bonifáz

Tirado‐Sánchez

Calderón

et al. 2015

Curr Fungal Infect Rep

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“…Ghost-like adipocytes are highly suggestive of pancreatic panniculitis, though they have also been reported in fungal panniculitis. 2 The mechanism of ghost cell formation is unknown;…”

Section: Discussion Follows On Page 78mentioning

confidence: 99%

“…The adipocytes were described as shadowy in two patients and ghost‐like in three patients because they were pale, devoid of nuclei, and possessed thick hazy outer membranes. Ghost‐like adipocytes are highly suggestive of pancreatic panniculitis, though they have also been reported in fungal panniculitis . The mechanism of ghost cell formation is unknown; it has been postulated that circulating pancreatic enzymes stimulate fat necrosis, but investigators have been unable to induce ghost cell change in adipocytes incubated with pancreatic enzymes .…”

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confidence: 99%