2005
DOI: 10.1105/tpc.104.027821
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Two Plant–Viral Movement Proteins Traffic in the Endocytic Recycling Pathway

Abstract: Many plant viruses exploit a conserved group of proteins known as the triple gene block (TGB) for cell-to-cell movement. Here, we investigated the interaction of two TGB proteins (TGB2 and TGB3) of Potato mop-top virus (PMTV), with components of the secretory and endocytic pathways when expressed as N-terminal fusions to green fluorescent protein or monomeric red fluorescent protein (mRFP). Our studies revealed that fluorophore-labeled TGB2 and TGB3 showed an early association with the endoplasmic reticulum (E… Show more

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Cited by 195 publications
(191 citation statements)
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References 83 publications
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“…Indirect support for this hypothesis comes also from the evidence that Arabidopsis PRA1, the small Rab GTPase interacting with MP (Huang et al, 2001), resides entirely in endosomal compartments/PVCs and colocalizes perfectly with ARA7 (Alvim Kamei et al, 2008). Taken together, these results suggest that CaMV MP becomes part of MVBs on the way to the vacuole, and evidence that Potato mop-top virus (PMTV) triple gene block2 also colocalizes in vesicles with ARA7 (Haupt et al, 2005) supports the hypothesis that viral proteins can exploit the endomembrane system for degradation.…”
Section: Discussionsupporting
confidence: 53%
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“…Indirect support for this hypothesis comes also from the evidence that Arabidopsis PRA1, the small Rab GTPase interacting with MP (Huang et al, 2001), resides entirely in endosomal compartments/PVCs and colocalizes perfectly with ARA7 (Alvim Kamei et al, 2008). Taken together, these results suggest that CaMV MP becomes part of MVBs on the way to the vacuole, and evidence that Potato mop-top virus (PMTV) triple gene block2 also colocalizes in vesicles with ARA7 (Haupt et al, 2005) supports the hypothesis that viral proteins can exploit the endomembrane system for degradation.…”
Section: Discussionsupporting
confidence: 53%
“…With endocytosis established as a fundamental plant transport process, it is conceivable that, due to their obligate nature, plant viruses use such mechanisms to support essential functions like replication and movement. Although a few plant viral proteins have been shown to interact or colocalize with components of the endocytic pathway (Haupt et al, 2005;Lewis and Lazarowitz, 2010), the crucial interaction with an AP-2-like complex, which mediates protein internalization from the PM, remains to be proved not only for plant virus proteins but for any protein in plants.…”
Section: Discussionmentioning
confidence: 99%
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“…In the CiLV-C pathosystem, there is a particular interest to follow the MP expression and its fate in the plant cells to understand why the infection is localized and not systemic. It is important to point out that most of the studies related to MPs are concentrated in their function or loss of function through mutations, production of transgenic plants, cellular localization and increasing of the size exclusion limit of the plasmodesmata, and interaction with other proteins in protoplasts cells (Wolf et al, 1989;Deom et al, 1990;Haupt et al, 2005;Akamatsu et al, 2007). Moreover, the peculiarity of MPs as non structural proteins contributes to the scarcity of studies related to antibody production and in vivo detection.…”
mentioning
confidence: 99%
“…MPs are present in the genomes of most plant viruses and are implicated in cell-to-cell movement of the infectious material associated with the plasmodesmata (Wolf et al, 1989;Deom et al, 1990;Haupt et al, 2005;Akamatsu et al, 2007). In the CiLV-C pathosystem, there is a particular interest to follow the MP expression and its fate in the plant cells to understand why the infection is localized and not systemic.…”
mentioning
confidence: 99%