Two-ply biodegradable nerve guide: basic aspects of design, construction and biological performance

Hoppen, Hj; Leenslag, Jw; Pennings, A. J.; Vanderlei, B; Robinson, P. H.

doi:10.1016/0142-9612(90)90012-f

Cited by 78 publications

(41 citation statements)

References 19 publications

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“…As the degradation products are nontoxic, the use of this aliphatic polyester copolymer is preferable. Hoppen et al [127] have reported constructing a nerve guide using PLCL as the inner microporous layer with a pore size range of 0.5-1.0 μm. The potential for combining PLCL sponges with collagen, whether by filling or by coating, has been investigated by Taira et al [128] for use as a future dental biomaterial.…”

Section: Scaffold Design Concepts and Strategiesmentioning

confidence: 99%

Design concepts and strategies for tissue engineering scaffolds

Chung

King

2011

Biotech and App Biochem

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In the emerging field of tissue engineering and regenerative medicine, new viable and functional tissue is fabricated from living cells cultured on an artificial matrix in a simulated biological environment. It is evident that the specific requirements for the three main components, cells, scaffold materials, and the culture environment, are very different, depending on the type of cells and the organ‐specific application. Identifying the variables within each of these components is a complex and challenging assignment, but there do exist general requirements for designing and fabricating tissue engineering scaffolds. Therefore, this review explores one of the three main components, namely, the key concepts, important parameters, and required characteristics related to the development and evaluation of tissue engineering scaffolds. An array of different design strategies will be discussed, which include mimicking the extra cellular matrix, responding to the need for mass transport, predicting the structural architecture, ensuring adequate initial mechanical integrity, modifying the surface chemistry and topography to provide cell signaling, and anticipating the material selection so as to predict the required rate of bioresorption. In addition, this review considers the major challenge of achieving adequate vascularization in tissue engineering constructs, without which no three‐dimensional thick tissue such as the heart, liver, and kidney can remain viable.

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Section: Scaffold Design Concepts and Strategiesmentioning

confidence: 99%

Design concepts and strategies for tissue engineering scaffolds

Chung

King

2011

Biotech and App Biochem

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“…This type of construction allows support and retention. 22,161,182,183 Nonporous thin skin on the inner surface of the tube is the primary permeability barrier and serves to retain neurotrophic factor. An external layer of thicker porosity external layer provides structural of anisotropic ultrafiltration membranes used for separating proteins from cells and/or smaller molecules.…”

Section: Bioartificial Nerve Grafts and Neural Tissue Engineeringmentioning

confidence: 99%

“…28,85,92,94,171 It is possible to increase the axonal elongation and accelerate the nerve generation by the Schwann cell production. 133,181,92,182,183 Many components are used and comparative studies are carried on in the scaffold technology. 178 The comparative studies are also carried out between the ''isotropic'' scaffolds with a homogenous content and between the ''anisotropic'' scaffolds which are not homogenous and with an irregular settlement of intraluminal content.…”

Section: Intraluminal Conduit Components/scaffoldsmentioning

confidence: 99%

Regeneration and repair of peripheral nerves with different biomaterials: Review

2010

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Peripheral nerve injury may cause gaps between the nerve stumps. Axonal proliferation in nerve conduits is limited to 10-15 mm. Most of the supportive research has been done on rat or mouse models which are different from humans. Herein we review autografts and biomaterials which are commonly used for nerve gap repair and their respective outcomes. Nerve autografting has been the first choice for repairing peripheral nerve gaps. However, it has been demonstrated experimentally that tissue engineered tubes can also permit lead to effective nerve repair over gaps longer than 4 cm repair that was previously thought to be restorable by means of nerve graft only. All of the discoveries in the nerve armamentarium are making their way into the clinic, where they are, showing great potential for improving both the extent and rate of functional recovery compared with alternative nerve guides.

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“…It is difficult to acquire donor nerves for grafting. Thus, considerable research has been conducted on peripheral nerve repair using the nerve bridge technique (Rosen et al, 1983Jenq and Coggeshall, 1984, 1987Seckel et al, 1984;Satou et al, 1986;Le Beau et al, 1988;Gibson and Daniloff, 1989;Hoppen et al, 1990;Aldini et al, 1996;Lundborg and Kanje, 1996). A nerve bridge technique is the introduction of the proximal and distal ends of a severed nerve into a tubular structure, which may or may not contain substances or other adjuncts for experimental purposes or to further promote healing.…”

Section: Statement Of the Problemmentioning

confidence: 99%

Development of a Multiple-Lumen Nerve Cuff Utilizing Growth Stimulant Patterns for Controlled Regeneration

et al. 1998

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This manuscript has been reproduced from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer. In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book.

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Two-ply biodegradable nerve guide: basic aspects of design, construction and biological performance

Cited by 78 publications

References 19 publications

Design concepts and strategies for tissue engineering scaffolds

Design concepts and strategies for tissue engineering scaffolds

Regeneration and repair of peripheral nerves with different biomaterials: Review

Development of a Multiple-Lumen Nerve Cuff Utilizing Growth Stimulant Patterns for Controlled Regeneration

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