Two-Pronged Strategy of Biomechanically Active and Biochemically Multifunctional Hydrogel Wound Dressing To Accelerate Wound Closure and Wound Healing

Abstract

A two-pronged strategy of biomechanically active and biochemically functional hydrogel wound dressing which can assist wound closure and have multiple functions to promote wound healing has been rarely reported. Herein, we designed a series of biomechanically active injectable self-healing hydrogels based on quaternized chitosan (QCS), polydopamine-coated reduction graphene oxide (rGO-PDA), and poly­(N-isopropylacrylamide) (PNIPAm) as multifunctional wound dressings to promote wound closure and wound healing. These biomechanically active wound dressings have excellent thermoresponsive self-contraction and tissue adhesion properties. They adhere strongly to the skin and assist wound closure by actively contracting wounds through self-contraction. Moreover, these hydrogels exhibit biochemical multifunctions that are beneficial to wound healing, including good self-healing property, temperature-dependent drug release ability, anti-infection, antioxidation, and conductivity. The in vivo full-thickness skin defect model demonstrates that the hydrogel dressings significantly promoted wound closure with accelerated wound contraction and promoted the wound-healing process with higher granulation tissue thickness, collagen disposition, and enhanced vascularization. In summary, the biomechanically active injectable self-healing conductive adhesive hydrogels promoted wound healing by assisting wound closure and biochemical functions, opening a two-pronged strategy approach to wound management through combining biomechanical and biochemical functions together.

Exosome loaded genipin crosslinked hydrogel facilitates full thickness cutaneous wound healing in rat animal model

“…Li et al. first invented and reported a series of antioxidant conductive injectable self-healing hydrogels, aiming to synchronize biomechanical and biochemical activity of the hydrogels for wound healing acceleration effect (Li et al., 2020 ). Furthermore, the synergistic effect of multi-functional hydrogel and therapeutic active factors is a fascinating approach for full-thickness wounds therapy (Shi et al., 2017 ; Qu et al., 2018 ; Liang et al., 2019 ).…”

Synergistic enhancement of tendon-to-bone healing via anti-inflammatory and pro-differentiation effects caused by sustained release of Mg2+/curcumin from injectable self-healing hydrogels

“…The hydrogels were evaluated by Fourier transform infrared spectroscopy (FT-IR) 23 and their morphology 24 - 26 , injectability 27 , adhesive ability 28 , 29 , self-healing performance 30 , 31 , rheological properties 32 , 33 , and in vitro and in vivo degradation profiles 28 were tested. The details are available in the supplementary information .…”

Preparation of Polyurethane/Pluronic F127 Nanofibers Containing Peppermint Extract Loaded Gelatin Nanoparticles for Diabetic Wounds Healing: Characterization, In Vitro, and In Vivo Studies

“…Also, the presence of necrosis was detected for all samples. For sample covered with PU/F/15/10 nanofibers, regenerative responses and tissue granulation were observed on day 7. e granulation tissue is an important indicator for evaluating wound healing [57]. For PU/F/15 treated wound, the crusty scab covered the wound area, and the inflammation was also evident in the defect on day 14.…”