2014
DOI: 10.1016/j.jaap.2014.10.007
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Two pyrolysate products from Omani frankincense smoke: First evidence of thermal aromatization of boswellic acids

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Cited by 11 publications
(9 citation statements)
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“…10,11 Recently, AKBA was also found to exhibit antitumor effects in human cell lines established from prostate cancer, breast cancer and glioblastoma. [12][13][14] Csuk et al demonstrated that boswellic acid and its derivatives induce apoptosis in breast and cervical cancers cells. 15 Liu indicated that AKBA inhibits the proliferation and cancer stem cell-like properties of docetaxel resistant prostate cancer cells in vitro and in vivo via blocking Akt and Stat3 signaling.…”
Section: Introductionmentioning
confidence: 99%
“…10,11 Recently, AKBA was also found to exhibit antitumor effects in human cell lines established from prostate cancer, breast cancer and glioblastoma. [12][13][14] Csuk et al demonstrated that boswellic acid and its derivatives induce apoptosis in breast and cervical cancers cells. 15 Liu indicated that AKBA inhibits the proliferation and cancer stem cell-like properties of docetaxel resistant prostate cancer cells in vitro and in vivo via blocking Akt and Stat3 signaling.…”
Section: Introductionmentioning
confidence: 99%
“…In contrast, boscartin M, isoincensole oxide, incensole oxide, and incensole oxide acetate had a mild hepatoprotective effect at 10 μM [25]. In the other report by Wang et al, the investigation of B. sacra led to the isolation of ten new cembrane-type diterpenes, including boscartins AL-AU (25)(26)(27)(28)(29)(30)(31)(32)(33)(34) and five known analogs (35)(36)(37)(38)(39). Moreover, biological evaluations revealed that compounds 27, 29, 36, and 37 displayed hepatoprotective activities against paracetamol-induced HepG2 cell damage at 10 μM.…”
Section: Diterpenoidsmentioning
confidence: 98%
“…Two compounds, namely, 1,2,4a,9tetramethyl-1,2,3,4,4a,5,6,14b-octahydropicene (70) and 2,9-dimethylpicene (71) were isolated from an n-hexane extract of the smoke-saturated water. Compounds 70 and 71 were evaluated for their antiproliferative activity against MDA-MB-231 breast cancer cells, and it was observed that these pyrolysate products were able to inhibit cancer cell growth [31]. A new ursane-type triterpene, namely, nizwanone (72) was reported from Omani frankincense B. sacra Flueck along with two known compounds papyriogenin B (73) and rigidenol (74) by Al-Harrasi et al [32].…”
Section: Diterpenoidsmentioning
confidence: 99%
“…The resin in the market is mostly taken from the Boswellia sacra, Boswellia carteri, Boswellia serrata, and Boswellia papyrifera. Several phytochemicals have been isolated from frankincense which include the boswellic acid type, triterpenoids, and nonterpenoids.These phytochemicals exhibit anti-inflammatory, antioxidant, and anti-cancer activity, among others (Al-Harrasi and Al-Saidi, 2008;Al-Harrasi et al, 2014;and Khajehdehi et al, 2022).…”
Section: Introductionmentioning
confidence: 99%