Two randomized controlled trials for colorectal cancer screening invitations developed using a behavioral science approach

Tinmouth, Jill; Llovet, Diego; Sutradhar, Rinku; Tsiplova, Kate; Roushani, Jian; Lee, Alex; Hader, Joanne; Rabeneck, Linda; Paszat, Lawrence

doi:10.1016/j.ypmed.2021.106918

Cited by 2 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…45 This evidence supports a population-based targeted OC screening program in these high-prevalence countries, with 3 years being an established maximum time gap between 2 tests to ensure the protective effect of screening. 46 As adherence is critical to successful repeated screenings, adherence-enhancing interventions, such as routinely mailed invitations, 47 should be explored. To further increase screening uptake and adherence, novel examination methods, including telescreening, may represent cost-effective and sensitive alternatives to clinician-conducted examinations, especially in more resource-restrained settings, although the limitations of this approach (eg, poor image quality) need to be thoroughly examined.…”

Section: Discussionmentioning

confidence: 99%

Methods, Detection Rates, and Survival Outcomes of Screening for Head and Neck Cancers

Sykes,

Weisbrod,

Rival

et al. 2023

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

ImportanceHead and neck cancers (HNCs) are often diagnosed at advanced clinical stages during their symptomatic phase, leading to a reduced treatment window and poor survival. Screening programs have been suggested as a mitigation strategy.ObjectiveTo examine the effectiveness of current HNC screening programs in improving diagnosis and survival in adults.Evidence ReviewThis Preferred Reporting Items for Systematic Reviews and Meta-analyses–guided systematic review involved use of peer-reviewed, English-language journal articles identified from MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials between January 1, 2001, and July 15, 2022. Snowballing was applied to retrieve more studies. Eligible articles were original clinical trials and observational studies presenting a universal or risk-targeted screening program of primary HNC in the adult population. Reporting quality was assessed using the JBI’s critical appraisal tools.FindingsDatabase searches yielded 3646 unique citations with an additional 8 studies found via snowballing. Five reviewers assessed the full text of 106 studies. Sixteen articles were ultimately included in the review, involving 4.7 million adults (34.1%-100% male; median age, 30-59 years). Fifteen studies were based in Asia and 1 in Europe (Portugal). Five reported data from randomized clinical trials. An oral inspection conducted once or once every 2 to 3 years was described in 11 studies for screening oral cancer, while multistep screening involving Epstein-Barr virus serologic testing for nasopharyngeal carcinoma delivered every 1 to 4 years was presented in 5. In 4 trials and 6 observational studies, screening significantly increased the detection of localized (stage I/II) tumor or was associated with an increased proportion of diagnoses, respectively, regardless of the population and cancer subsites. Universal screening of asymptomatic adults improved 3- to 5-year overall survival but did not increase cancer-specific survival in 4 trials. Targeted screening improved overall and cancer-specific survival or was associated with improved survival outcomes in 2 trials and 2 observational studies, respectively. Studies had low to medium risks of bias.Conclusions and RelevanceEvidence from the existing literature suggests that a risk-targeted screening program for oral and nasopharyngeal cancers could improve diagnosis and patient survival. Screening adherence, societal cost-effectiveness, and optimal risk stratification of such a program warrant future research, especially in low-incidence settings outside Asia.

show abstract

Section: Discussionmentioning

confidence: 99%

Methods, Detection Rates, and Survival Outcomes of Screening for Head and Neck Cancers

Sykes,

Weisbrod,

Rival

et al. 2023

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…Focus group participants shared their views on the minimum requirements for informing and engaging the target population in a personalised CRC screening programme. The organisational structure may already be optimal: sending a pre-invitation letter, then mailing an invitation including a test kit and a reminder letter if necessary ( Tinmouth et al, 2022 , Toes-Zoutendijk et al, 2020 ). Despite the success of the media campaign when CRC screening started in 2014, focus group participants indicated that there is no general awareness of the CRC screening programme at present and a hardcopy letter is insufficient.…”

Section: Discussionmentioning

confidence: 99%

Personalised colorectal cancer screening strategies: Information needs of the target population

Toes‐Zoutendijk

Jonge

Breekveldt

et al. 2023

Preventive Medicine Reports

View full text Add to dashboard Cite

Two randomized controlled trials for colorectal cancer screening invitations developed using a behavioral science approach

Cited by 2 publications

References 20 publications

Methods, Detection Rates, and Survival Outcomes of Screening for Head and Neck Cancers

Methods, Detection Rates, and Survival Outcomes of Screening for Head and Neck Cancers

Personalised colorectal cancer screening strategies: Information needs of the target population

Contact Info

Product

Resources

About