Two rare cases of oral metastasis arising from lung adenocarcinoma and esophageal carcinoma

Abstract

Metastasis to the oral cavity are rare, representing only 1% of all oral malignancies, and originate from various sites such as the breast, prostate, lung and kidney. Clinically, they can simulate reactive and inflammatory lesions common in the oral cavity, and the clinical and microscopic diagnosis of these metastasis is a challenge. In this article, we report two new cases of esophageal and lung metastasis to oral tissues, highlighting their clinical characteristics and the process of diagnostic elucidation. We emphasize the importance for clinicians to consider the possibility of metastatic lesions in the oral cavity in patients previously diagnosed with malignant lesions in distant tissues and organs. Key words: Diagnosis, esophageal squamous cell carcinoma, adenocarcinoma of lung, oral cavity, metastasis.

Rare Metastasis of Esophageal Adenocarcinoma to the Female Reproductive Tract

“…3 Recent literature has shown metastases to unusual sites. [4][5][6][7] Shaheen et al 10 found the most common unexpected metastatic site group was the head and neck, and of specific organs, skin was most common. Within abdominopelvic, the kidneys, pancreas, and spleen were most common.…”

“… 3 Reports indicating uncommon metastatic sites include maxillary bone, 4 skeletal muscle, 5 subcutaneous tissue, 6 and the oral cavity. 7 However, scant literature has been published regarding metastasis to the female reproductive tract, with only 2 published cases demonstrating esophageal metastasis to the ovaries. 8 , 9 Early detection may prevent unproductive treatment and improve prognosis.…”