Objective: This case improves the early etiologic diagnosis of recurrent and refractory secretory otitis media, avoiding missed diagnosis and misdiagnosis.Methods: Collecting the clinical manifestations of this case, fiberoptic otoscopy + fiber nasopharyngoscopy and imaging features.Results: This patient was admitted to the hospital with hearing loss and ear suffocation. He did not find the cause at the beginning of the disease. Before the hospital, he underwent the treatment of tympanic incision and eustachian tube balloon expansion with simple secretory otitis media, but still recurrent, he came into our hospital through imaging and other further examination this time, having the clear cause that the secretory otitis media recurrent episodes due to tumor lesions in the pterygopalatine. Under the general anesthesia, the navigation system assisted the endoscopic sinus combined with the cryo-plasma wing axillary tumor resection, and the right ear tympanic membrane incision was performed under the microscope.Conclusions: Clinicians need to be cautious and consider the causes in order to reduce missed diagnosis and misdiagnosis, and provide early diagnosis and early treatment to improve the quality of life of patients.