Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists

Troncoso, Julieta; Maldonado, Héctor

doi:10.1016/s0091-3057(01)00779-1

Cited by 31 publications

(28 citation statements)

References 53 publications

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“…In summary, our results obtained with honeybees, together with the recent report on Drosophila, provide independent evidence for the role of glutamate in memory formation in insects; this data furthermore supports the notion that glutamatergic neurotransmission is a conserved key element in neural plasticity, as demonstrated previously for other species and phyla (Troncoso and Maldonado, 2002;Riedel et al, 2003;Roberts and Glanzman, 2003).…”

Section: Discussionsupporting

confidence: 90%

Focal and Temporal Release of Glutamate in the Mushroom Bodies Improves Olfactory Memory inApis mellifera

Locatelli

Bundrock²,

Müller³

2005

J. Neurosci.

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In contrast to vertebrates, the role of the neurotransmitter glutamate in learning and memory in insects has hardly been investigated. The reason is that a pharmacological characterization of insect glutamate receptors is still missing; furthermore, it is difficult to locally restrict pharmacological interventions. In this study, we overcome these problems by using locally and temporally defined photo-uncaging of glutamate to study its role in olfactory learning and memory formation in the honeybee, Apis mellifera. Uncaging glutamate in the mushroom bodies immediately after a weak training protocol induced a higher memory rate 2 d after training, mimicking the effect of a strong training protocol. Glutamate release before training does not facilitate memory formation, suggesting that glutamate mediates processes triggered by training and required for memory formation. Uncaging glutamate in the antennal lobes shows no effect on memory formation. These results provide the first direct evidence for a temporally and locally restricted function of glutamate in memory formation in honeybees and insects.

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Section: Discussionsupporting

confidence: 90%

Focal and Temporal Release of Glutamate in the Mushroom Bodies Improves Olfactory Memory inApis mellifera

Locatelli

Bundrock²,

Müller³

2005

J. Neurosci.

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“…This drug has been widely used as anamnesic agent in several memory tasks in different species (Morris et al 1986;Tan et al 1989;Miserendino et al 1990;Lin and Glanzman 1994;Rickard et al 1994;Weldon et al 1997;Gutiérrez et al 1999;Roberts and Glanzman 2003;Si et al 2004;Xia et al 2005;Wu et al 2007;Kano et al 2008;Müssig et al 2010;Rosenegger and Lukowiak 2010;Amano and Maruyama 2011). Moreover, MK801 caused amnesic effects in consolidation (Troncoso and Maldonado 2002), reconsolidation and extinction (Pérez-Cuesta and Maldonado 2009) in Chasmagnathus, consistent with the presence of NMDAR in the crab CNS (Hepp et al 2013). During the training session on Day 1, we established three pairs of CT-TR groups.…”

Section: Inhibition Of the Ups Blocks The Action Of Mk801 And Bicuculmentioning

confidence: 79%

Protein degradation by ubiquitin–proteasome system in formation and labilization of contextual conditioning memory

et al. 2014

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The ubiquitin -proteasome system (UPS) of protein degradation has been evaluated in different forms of neural plasticity and memory. The role of UPS in such processes is controversial. Several results support the idea that the activation of this system in memory consolidation is necessary to overcome negative constrains for plasticity. In this case, the inhibition of the UPS during consolidation impairs memory. Similar results were reported for memory reconsolidation. However, in other cases, the inhibition of UPS had no effect on memory consolidation and reconsolidation but impedes the amnesic action of protein synthesis inhibition after retrieval. The last finding suggests a specific action of the UPS inhibitor on memory labilization. However, another interpretation is possible in terms of the synthesis/degradation balance of positive and negative elements in neural plasticity, as was found in the case of long-term potentiation. To evaluate these alternative interpretations, other reconsolidation-interfering drugs than translation inhibitors should be tested. Here we analyzed initially the UPS inhibitor effect in contextual conditioning in crabs. We found that UPS inhibition during consolidation impaired long-term memory. In contrast, UPS inhibition did not affect memory reconsolidation after contextual retrieval but, in fact, impeded memory labilization, blocking the action of drugs that does not affect directly the protein synthesis. To extend these finding to vertebrates, we performed similar experiments in contextual fear memory in mice. We found that the UPS inhibitor in hippocampus affected memory consolidation and blocked memory labilization after retrieval. These findings exclude alternative interpretations to the requirement of UPS in memory labilization and give evidence of this mechanism in both vertebrates and invertebrates.

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“…Instead, it has no effect on CS-US memory acquisition nor on its retrieval (Troncoso and Maldonado 2002). These findings suggested a role for NMDA-like receptors in the storage of long-term memory in the crab.…”

Section: Activity Of Nmda-like Receptors Is Required For Acquisition mentioning

confidence: 79%

“…Prior experiments in our laboratory showed that an injection of 1 µg/g of MK-801, the vertebrate noncompetitive antagonist of NMDA receptors, disrupts the crab's CS-US memory consolidation (Troncoso and Maldonado 2002) and reconsolidation (Pedreira et al 2002). Instead, it has no effect on CS-US memory acquisition nor on its retrieval (Troncoso and Maldonado 2002).…”

Section: Activity Of Nmda-like Receptors Is Required For Acquisition mentioning

confidence: 94%

Memory is not extinguished along with CS presentation but within a few seconds after CS-offset

Pérez-Cuesta¹,

Hepp²,

Pedreira³

et al. 2007

Learn. Mem.

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Prior work with the crab's contextual memory model showed that CS-US conditioned animals undergoing an unreinforced CS presentation would either reconsolidate or extinguish the CS-US memory, depending on the length of the reexposure to the CS. Either memory process is only triggered once the CS is terminated. Based on these results, the following questions are raised. First, when is extinction memory acquired, if not along extinction training, and how long does it take? Second, can acquisition and consolidation of extinction memory be pharmacologically dissected? Here we address these questions performing three series of experiments: a first one aimed to study systematically the relationship between extinction and increasing periods of unreinforced CS presentations, a second one to determine the time boundaries of the extinction memory acquisition, and the third one to assay the requirement for protein synthesis and NMDA-like receptors of acquisition and consolidation of extinction memory. Our results confirm that it is CS-offset and not the mere retrieval (CS-onset) that triggers acquisition of extinction memory and that it is completed in less than 45 sec after CS-offset. In addition, protein synthesis is required for consolidation but not for acquisition of this memory and, conversely, NMDA-like receptor activity is required for its acquisition but not for its consolidation. Finally, we offer an interpretative scheme of our results and we discuss to what extent it could apply to multitrial extinction.

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Two related forms of memory in the crab Chasmagnathus are differentially affected by NMDA receptor antagonists

Cited by 31 publications

References 53 publications

Focal and Temporal Release of Glutamate in the Mushroom Bodies Improves Olfactory Memory inApis mellifera

Focal and Temporal Release of Glutamate in the Mushroom Bodies Improves Olfactory Memory inApis mellifera

Protein degradation by ubiquitin–proteasome system in formation and labilization of contextual conditioning memory

Memory is not extinguished along with CS presentation but within a few seconds after CS-offset

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