Two siblings below the age of 20 years with diverticular disease

The TNFSF15 Gene Single Nucleotide Polymorphism rs7848647 Is Associated With Surgical Diverticulitis

“…[23][24][25][26][27] Twin studies, perhaps the best human model for assessing genetic influence on disease, show significant concordance of early onset of severe diverticular disease in identical twins that decreases when fraternal twins are studied. Several familial case studies have reported multiple siblings with diverticular disease, similar to the family in this study.…”

The genetic influence on diverticular disease – a twin study

“…Little research has been done on describing the influence of a genetic component. Several case reports describing DD within families have been published but to the best of our knowledge this is the first population‐based twin study that has studied genetic risk factors of DD.…”

“…Other life style factors have been suggested to be of importance, such as smoking, excessive nutritional intake and physical inactivity but it is largely unknown whether or not genetic susceptibility plays an important role in the development of DD . A number of case reports have been published describing families with DD . Moreover, clinical observations relate several genetic disorders such as Ehlers‐Dannlos syndrome, autosomal dominant polycystic kidney disease and Williams‐Beuren syndrome with a strong predisposition towards diverticula formation .…”

Diet, ageing and genetic factors in the pathogenesis of diverticular disease

“…Perez-Atayde et al [94] observed a duodenal diverticulum in a 14-year-old with mitochondrial neurogastrointestinal encephalomyopathy which suggests that mitochondrial neuromuscular dysfunction may be associated with DD. On a different note, clinical case reports hint at familial risk factors for DD in the general population; Schlotthauer reported DD in seven American brothers (aged 40-70), but not in their two sisters (ages not given) [95] ; Omojola and Mangete [96] observed DD in three siblings in a Nigerian population with a traditionally low incidence of DD and Claassen et al [97] observed DD in two teenage siblings in Holland, in whom they also noted joint hypermobility, perhaps indicating a collagen disorder. Siblings share similar environmental exposure which may help explain familial clustering of DD but does not account for observations in populations where the prevalence is low or in the very young.…”