In this paper the notion of derivations on Γ-generalized Boolean semiring are established, namely Γ-( f, g) derivation and Γ-( f, g) generalized derivation. We also investigate the commutativity of prime Γ-generalized Boolean semiring admitting Γ-( f, g) derivation and Γ-( f, g) generalized derivation satisfying some conditions.