1998
DOI: 10.1074/jbc.273.17.10556
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Two Signaling Mechanisms for Activation of αMβ2 Avidity in Polymorphonuclear Neutrophils

Abstract: Circulating polymorphonuclear neutrophils (PMN) are quiescent, nonadherent cells that rapidly activate at sites of inflammation, where they develop the capacity to perform a repertoire of functions that are essential for host defense. Induction of integrin-mediated adhesion, which requires an increase in integrin avidity, is critical for the development of these effector functions. Although a variety of stimuli can activate integrins in PMN, the signaling cascades involved are unclear. Phosphatidylinositol (PI… Show more

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Cited by 132 publications
(133 citation statements)
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“…We reported previously that cervical infection by gonococci elicits membrane ruffling that is accompanied by a concentrated accumulation of the actin-associated proteins ezrin and vinculin . Jones et al (1998) have described two CR3 signalling pathways, both of which lead to the activation of p21 activating kinase 1 (PAK1). PAK1 is a serine/threonine kinase that can regulate the formation of vinculin-containing focal complexes and membrane ruffling both independently of and dependent on the action of Rac (Sells et al, 1997;Obermeier et al, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…We reported previously that cervical infection by gonococci elicits membrane ruffling that is accompanied by a concentrated accumulation of the actin-associated proteins ezrin and vinculin . Jones et al (1998) have described two CR3 signalling pathways, both of which lead to the activation of p21 activating kinase 1 (PAK1). PAK1 is a serine/threonine kinase that can regulate the formation of vinculin-containing focal complexes and membrane ruffling both independently of and dependent on the action of Rac (Sells et al, 1997;Obermeier et al, 1998).…”
Section: Discussionmentioning
confidence: 99%
“…We have reported that PAK1 activity in human neutrophils is stimulated by immune complex activation of FcRII receptors [26]. As a first step in determining the role of PAK1 in the complement (C3b) receptor-mediated phagocytic process, PAK1 and F-actin distribution was monitored after addition of OZ particles (Fig.…”
Section: Pak1 Localizes To Pseudopodia and Phagocytic Cups During Phamentioning
confidence: 99%
“…The binding of PAKs to the active GTP forms of Rac and Cdc42 stimulates PAK activity toward exogenous substrates. Both G-protein-coupled chemoattractant receptors and Fc receptors regulate PAK activity in human leukocytes [25,26]. In non-immune cells, PAKs have been implicated in the regulation of the stress-activated MAP kinases, p38 and JNK [27,28], and in cytoskeletal rearrangement [29][30][31][32].…”
Section: Introductionmentioning
confidence: 99%
“…18 Like most other integrins, the affinity of ␣M␤2 for ligands dramatically increases after activation by various stimuli, and its avidity is increased by the translocation to the cell surface of granular stores, a process that parallels the shedding of L-selectin from the surface of neutrophils. 19,20 Although defects in leukocyte adhesion have been described in ␣M-deficient mice (␣M Ϫ/Ϫ ), these mice do not exhibit steady-state leukocytosis. In addition, ␣M Ϫ/Ϫ neutrophils exhibit deficient phagocytosis and reduced-oxygen free-radical generation and are more resistant to apoptosis.…”
Section: Introductionmentioning
confidence: 99%