Given a 2-manifold, a fundamental question to ask is which groups can be realized as the isometry group of a Riemannan metric of constant curvature on the manifold. In this paper, we give a nearly complete classification of such groups for infinite-genus 2-manifolds with no planar ends. Surprisingly, we show there is an uncountable class of such 2-manifolds where every countable group can be realized as an isometry group (namely, those with self-similar end spaces). We apply this result to obtain obstructions to standard group theoretic properties for the groups of homeomorphisms, diffeomorphisms, and the mapping class groups of such 2manifolds. For example, none of these groups satisfy the Tits Alternative; are coherent; are linear; are cyclically or linearly orderable; or are residually finite. As a second application, we give an algebraic rigidity result for mapping class groups.