Two-stage hepatectomy for liver metastasis from colorectal cancer

Selby, Keegan; Hernandez‐Alejandro, Roberto

doi:10.1503/cmaj.131022

Cited by 9 publications

(10 citation statements)

References 9 publications

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“…A period of 8-12 weeks should be sufficient to reach adequate functional FLRV values in standard TSH treatment. On the other hand, advanced Associating Liver Partition and Portal vein Ligation for Staged hepatectomy (ALPPS) require 7-10 days to reach optimal FRLV (Selby and Hernandez-Alejandro, 2014; Zhou et al ., 2017; Sandstrom et al ., 2018).…”

Section: Review and Reassessment Of Previous Studymentioning

confidence: 99%

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Comment on surgical approaches for definitive treatment of hepatic alveolar echinococcosis: results of a survey in 178 patients

Akbulut

Sahin

2020

Parasitology

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Echinococcus multilocularis causes alveolar echinococcosis which is a chronic, progressive zoonotic disease that mainly affects the liver. Hepatic alveolar echinococcosis is insidious and the patients are asymptomatic most of the time. Generally, it is incidentally found on imaging studies performed for other reasons. Specific symptoms may evolve if the vascular and biliary structures of the liver are affected. Hepatic alveolar echinococcosis shows a similar pattern to malignancies in terms of radiologic and clinical features. For this reason, oncological surgical principles should be applied during the resection of hepatic alveolar echinococcosis. The gold standard surgical treatment is resection with negative surgical margin. However, in patients whose radical resection is not possible other therapeutic options include palliative resection which has no benefit to the patient, and other curative major surgical options such as ex vivo liver resection, and autotransplantation and ultimately liver transplantation. The remnant liver volume has paramount importance if resection is going to be performed. For this reason, occasionally, remnant liver volume hypertrophy is induced by employing either two-stage hepatectomy or associating liver partition and portal vein ligation for staged hepatectomy.

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Section: Review and Reassessment Of Previous Studymentioning

confidence: 99%

“…P3N 0−1 M0 10 (38.5) 7 (26.9) 9 (34.6) 0 (0) <0.001 (Selby and Hernandez-Alejandro, 2014;Zhou et al, 2017;Sandstrom et al, 2018). Current meta-analyses showed that results of ALPPS are superior to TSH (Zhou et al, 2017;Liu et al, 2019).…”

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confidence: 99%

Comment on surgical approaches for definitive treatment of hepatic alveolar echinococcosis: results of a survey in 178 patients

Akbulut

Sahin

2020

Parasitology

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“…Segment 4 ALPPS, in which the FLR is segment 4, has been described by multiple authors, including our own group [64,65]. This challenging modification consists of a left lateral sectionectomy, metastesectomy of segment 4, right PVL, and in situ split along Cantlie's line during the first stage of the operation.…”

Section: Segmental Modificationsmentioning

confidence: 99%

ALPPS: Challenging the concept of unresectability – A systematic review

Bertens

Hawel

Lung

et al. 2015

International Journal of Surgery

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“…Complete liver resection of hepatic metastasis resulted in a median overall survival (OS) of 30–50 months, and 5-year survival of up to 50% [4]. The development of surgical techniques, such as two-stage hepatectomy and portal vein embolization, can increase the resectability rate even in patients with multiple, initially unresectable, liver metastases [5, 6]. For peritoneal metastasis, hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery (CRS) is effective for patients who can achieve complete cytoreduction.…”

Section: Introductionmentioning

confidence: 99%

Clinical outcomes of complete cytoreduction with concurrent liver resection followed by hyperthermic intraperitoneal chemotherapy for synchronous peritoneal and liver metastatic colorectal cancer

et al. 2019

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BackgroundThis study aimed to evaluate the clinical outcomes of concurrent liver resection with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in colorectal cancer patients with synchronous liver and peritoneal metastases.MethodsPatients with colorectal liver and peritoneal metastasis who underwent complete cytoreduction and hyperthermic intraperitoneal chemotherapy with concurrent liver surgery between September 2014 and July 2018 were included. Perioperative outcomes, overall survival, and progression-free survival were analyzed retrospectively.ResultsIn total, 22 patients were included. The median peritoneal cancer index was 13 (range, 0–26), and the median number of liver metastases was 3 (range, 1–13). The mean total operative time was 11.4 ± 2.6 h. Minor postoperative complications (Clavien-Dindo grade I–II) were reported in 10 patients (45.5%), and major postoperative complications (grade III–V) were reported in five patients (22.7%), including one mortality patient. The median overall survival since diagnosis with metastasis was 27.4 months. The median overall survival since surgical intervention and the progression-free survival were 16.7 months and 7.1 months, respectively.ConclusionsThis short-term follow-up study showed that, in an experienced center, combined resection with hyperthermic intraperitoneal chemotherapy for colorectal liver and peritoneal metastases was feasible and safe with acceptable oncologic outcomes.

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Two-stage hepatectomy for liver metastasis from colorectal cancer

Cited by 9 publications

References 9 publications

Comment on surgical approaches for definitive treatment of hepatic alveolar echinococcosis: results of a survey in 178 patients

Comment on surgical approaches for definitive treatment of hepatic alveolar echinococcosis: results of a survey in 178 patients

ALPPS: Challenging the concept of unresectability – A systematic review

Clinical outcomes of complete cytoreduction with concurrent liver resection followed by hyperthermic intraperitoneal chemotherapy for synchronous peritoneal and liver metastatic colorectal cancer

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