Two‐stage particle separation channel based on standing surface acoustic wave

Abstract

Microfluidic technology has great advantages in the precise manipulation of micro and nano particles, and the collection method of micro and nano particles based on ultrasonic standing waves has attracted much attention for its high efficiency and simplicity of structure. This article proposes a two-stage particle separation channel using ultrasound. In the microfluidic channel, two different sound pressure regions are used to achieve the separation of particles with positive acoustic contrast factors. Through numerical simulation, the performance of three common piezoelectric substrate materials was compared qualitatively and quantitatively, and it was found that the output sound pressure intensity of 128 • YX-LiNbO3 was high and the output was stable. At the same time, the influence of the number of electrode pairs of the interdigital transducer and the electrode voltage on the output sound wave is studied. Finally, 15 pairs of electrode pairs are selected, and the electrode voltages of the two sound pressure regions are 2.0 V and 3.0 V, respectively. After selecting the corresponding parameters, the separation process was numerically simulated, and the separation of three kinds of particles was successfully achieved. This work has laid a certain theoretical foundation for rapid disease diagnosis and real-time monitoring of the environment in practical applications.

Novel Study on the Mixing Mechanism of Active Micromixers Based on Surface Acoustic Waves

“…Currently, common piezoelectric materials available in the market include piezoelectric single crystals, piezoelectric ceramics, and piezoelectric thin films. 33 In this paper, we choose to use piezoelectric single crystals as the piezoelectric material for our study. It is more in line with the study of driving microfluidic mixing in this work.…”

“…The right choice may make the experiment smoother. Currently, common piezoelectric materials available in the market include piezoelectric single crystals, piezoelectric ceramics, and piezoelectric thin films . In this paper, we choose to use piezoelectric single crystals as the piezoelectric material for our study.…”

Investigation on submicron particle separation and deflection using tilted-angle standing surface acoustic wave microfluidics

“…Among these, the ultrasonic wave-based methods, which have the advantages of high integration, label-free, high efficiency, and biocompatibility, have attracted wide attention. Standing surface acoustic wave (SSAW) microfluidic utilizes interdigital transducers (IDTs) to generate a stable standing acoustic field in the fluidic channel and achieves separation based on differences in particle size [ [20] , [21] , [22] ] or other physical properties [ [23] , [24] , [25] ]. SSAW microfluidic can be divided into two types based on the angle of IDT and microchannel, parallel [ 23 , 24 ] and tilt type [ 26 ].…”

A Simulated Investigation of Lithium Niobate Orientation Effects on Standing Acoustic Waves

“…Numerical simulation analysis illustrated that the interference of the standing wave increased the out-of-plane amplitude of the waves, which improved the separation of cells/particles due to an increase in acoustic energy. Also, the length of the IDT affects the cell separation [8,[17][18][19][20]. Therefore, increasing the acoustic energy of the SAW could result in enhanced particle separation capabilities.…”